Nutritional Status and Quality of Life in HIV-infected patients

Abstract

Key words:HIV. Nutritional status. Quality of life. Palabras clave:VIH. Estado nutricional. Calidad de vida. ResumenIntroducción: el estado nutricional y la evolución del virus de inmunodefi ciencia humana (VIH) están interconectados. A pesar de que algunos estudios hayan visto el impacto del estado nutricional en la calidad de vida (CdV) en pacientes con enfermedades crónicas, pocos han estudiado sus efectos en pacientes infectados de VIH. Objetivo: investigar la relación entre el estado nutricional y la CdV en adultos recientemente diagnosticados de VIH. Métodos: cumplieron los criterios de inclusión los individuos diagnosticados de VIH en los 14 meses previos a una visita al hospital central de Lisboa. El estado nutricional fue evaluado por antropometría, análisis de la composición del cuerpo, y dieta, mientras que la CdV fue evaluada usando el cuestionario WHOQOL-HIV-BREF. También fueron considerados los datos sociodemográfi cos y clínicos. Resultados: fueron seleccionados 51 individuos, la mayoría de sexo masculino, caucásicos, empleados, solteros y en tratamiento antirretroviral de gran actividad (TARGA). Varias características sociodemográfi cas, como el nivel de educación, la edad, el sexo y el estado de salud actual, fueron importantes indicadores del nivel de CdV (p < 0,05). Se observaron niveles de CdV más bajos en individuos con dietas inadecuadas, pérdida de peso comprobada y elevado perímetro de cintura en análisis bivariado (p < 0,05). Las mismas variantes infl uenciaron negativamente la CdV tras haber ajustado los factores de confusión en análisis multivariado (p < 0,05). Conclusión: varios aspectos del estado nutricional infl uyeron en las variaciones observadas en la CdV, lo que sugiere que una intervención a nivel nutricional podría mejorar potencialmente la calidad de vida en esta población. AbstractIntroduction: Nutritional status and the progression of the human immunodefi ciency virus (HIV) are interlinked; though some studies have looked at the impact nutritional status has on quality of life (QoL) in patients with chronic diseases, few have studied this in HIV-infected individuals. Objective: To investigate the relationship between nutritional status and QoL in adults with a recent HIV diagnosis. Methods: Individuals with an HIV diagnosis performed in the fourteen months prior to a medical visit to one of Lisbon's central hospitals were eligible. Nutritional status was assessed by anthropometry, body composition analysis, and dietary intake. QoL was assessed using the WHOQOL-HIV-BREF questionnaire. Sociodemographic and clinical data were also considered. Results: Fifty-one subjects were eligible for enrolment; the majority were male, Caucasian, employed, single, and under highly active antiretroviral therapy (HAART). Lower QoL scores were observed in subjects with inadequate energy intakes, reported weight loss, and a high waist circumference in bivariate analysis (p < 0.05); the same variables infl uenced QoL negatively after adjusting for confounders in multivariate analysis (p < 0.05)...

Nutritional aberration and related morphological disorders among patients with human immunodeficiency virus infection on combination antiretroviral therapy (cART) in Ghana: A retrospective study

“…All patients were on first line antiretroviral management, with majority [67.8% (60.4–74.4)] on Tenofovir/Lamivudine/Efavirenz combination for a duration of 1–7 years at the time of this study ( Table 2 ). The clinical and pharmacological profile of PLHIV in this study compares favourably with similar works undertaken previously where averagely HIV individuals on 3–4 years of antiretroviral medication were associated with advanced stages of the disease [ 13 , 17 , 18 , 19 , 20 ].…”

Primary headache disorders in Latin America and the Caribbean: A meta-analysis of population-based studies

“…Overall Primary Headaches. Thirty subpopulations from 29 studies were included for this analysis (51)(52)(53)(55)(56)(57)(58)(60)(61)(62)(63)(64)(66)(67)(68)(69)(70)(71)(72)(74)(75)(76)(77)(78)(79)(80)(81)(83)(84)(85)(86)(87)(88)(89). The total number of individuals included were 54,357; from them, 20,828 cases of primary headache disorders were diagnosed.…”

“…Chronic Headache. Ten studies (53,57,61,68,69,71,77,78,81,82,84,85,89) (21,720 individuals; 948 cases) were analyzed. The prevalence of chronic headache was 6.05% (95% CI: 3.26%-9.62%; I 2 ¼ 98.51%).…”

Multicenter Study of Controlling Nutritional Status (CONUT) Score as a Prognostic Factor in Patients With HIV-Related Renal Cell Carcinoma

“…A high CONUT score means lower levels of albumin, lymphocytes, and cholesterol, which are often associated with poorer nutritional and immune status in patients and may lead to poorer survival ( 13 ). Maintaining optimal nutritional status can greatly improve quality of life while reducing comorbidities, progression of HIV infection, and HIV-related mortality ( 14 , 15 ). In addition, good nutrition also helps HIV-infected patients absorb HIV drugs ( 16 ).…”

“…In addition, good nutrition also helps HIV-infected patients absorb HIV drugs ( 16 ). The effects of poor nutritional status and HIV are synergistic and interrelated, thus amplifying their respective harmful effects ( 15 , 17 ). Increasing evidence suggests that, in addition to the genetic basis, host nutritional status and inflammatory responses also play an important role in cancer development and progression ( 18 ).…”