Nutritional Status and Nutrition Quality in Patients with Non-Alcoholic Fatty Liver Disease

Bender, Darija Vranešić; Nutrizio, Marinela; Jošić, Mirja; Kelečić, Dina Ljubas; Karas, Irena; Premužić, Marina; Domislović, Viktor; Rotim, Cecilija; Krznarić, Željko

doi:10.20471/acc.2017.56.04.07

Cited by 12 publications

(8 citation statements)

References 32 publications

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“…Impaired liver hemostasis of zinc may lead to oxidative stress and inflammation of liver in NAFLD patients [109]. Zinc transporters play a significant role in attenuation of endoplasmic reticulum (ER)-stress and hepatic steatosis, which increases in zinc deficient patients [110].…”

Section: Zinc In the Therapy Of Non-alcoholic Liver Disease (Nafld)mentioning

confidence: 99%

Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury

et al. 2021

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Zinc is the second most abundant trace element in the human body, and it plays a fundamental role in human physiology, being an integral component of hundreds of enzymes and transcription factors. The discovery that zinc atoms may compete with copper for their absorption in the gastrointestinal tract let to introduce zinc in the therapy of Wilson’s disease, a congenital disorder of copper metabolism characterized by a systemic copper storage. Nowadays, zinc salts are considered one of the best therapeutic approach in patients affected by Wilson’s disease. On the basis of the similarities, at histological level, between Wilson’s disease and non-alcoholic liver disease, zinc has been successfully introduced in the therapy of non-alcoholic liver disease, with positive effects both on insulin resistance and oxidative stress. Recently, zinc deficiency has been indicated as a possible factor responsible for the susceptibility of elderly patients to undergo infection by SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic. Here, we present the data correlating zinc deficiency with the insurgence and progression of Covid-19 with low zinc levels associated with severe disease states. Finally, the relevance of zinc supplementation in aged people at risk for SARS-CoV-2 is underlined, with the aim that the zinc-based drug, classically used in the treatment of copper overload, might be recorded as one of the tools reducing the mortality of COVID-19, particularly in elderly people.

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Section: Zinc In the Therapy Of Non-alcoholic Liver Disease (Nafld)mentioning

confidence: 99%

Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury

et al. 2021

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“…Individuals with obesity and NAFLD often consume a high proportion of fat [ 5 , 6 ]. The consumption of carbohydrates and sugar-sweetened beverages has been linked with adult and childhood obesity and NAFLD [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice

et al. 2018

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Obesity and nonalcoholic fatty liver disease (NAFLD) are highly prevalent and cause numerous metabolic diseases. However, drugs for the prevention and treatment of obesity and NAFLD remain unavailable. In this study, we investigated the effects of mogrosides (luo han guo, LH) in Siraitia grosvenorii saponins on high-fat-diet-induced obesity and NAFLD in mice. We found that compared with the negative control, LH reduced body and liver weight. LH also decreased fat accumulation and increased AMP-activated protein kinase (AMPK) phosphorylation (pAMPK) levels in mouse livers. We also found that high-purity mogroside V upregulated pAMPK expression in HepG2 cells. In addition, high-purity mogroside V inhibited reactive oxygen species production and upregulated sequestosome-1 (SQSTM1, p62) expression in THP-1 cells. These results suggest that LH may affect obesity and NAFLD by enhancing fat metabolism and antioxidative defenses. Mogroside V may be a main component of LH. However, the exact molecular mechanisms and active components responsible for the inhibitory effects of LH on obesity and NAFLD require further investigation.

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“…Thus, it is essential to improve the health and lifestyle habits of the general population, increase physical activity levels, and make education available across all age boundaries. bMi is largely dependent on the presence or absence of physical activity, but the frequency of physical activity is also an important factor affecting bMi [27][28][29][30][31] .…”

Section: Discussionmentioning

confidence: 99%

Are Croatian Blood Donors Obese?

Starčević

Mavrinac

Katalinić

et al. 2020

ACC

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The rising prevalence of overweight and obesity is characterized as a pandemic of the modern era. The purpose of this study was to analyze the prevalence of overweight and obesity in healthy blood donors in Primorje-Gorski Kotar County, Croatia, and the relationship between sociodemographic factors, lifestyle and eating habits, and body mass index (bMi), including the association of these factors with overweight and obesity. This cross-sectional study included 1255 healthy individuals aged between 18 and 70 years who donated blood between January 2015 and October 2016 at the Clinical institute of transfusion Medicine. each participant completed a questionnaire regarding weight, height, blood type, socio-demographic factors, health parameters, physical activity, alcohol consumption, and smoking habits. Overweight was defined as bMi of 25-29.9 kg/m 2 , and obesity as bMi ≥30 kg/m 2. A logistic regression model was used on data assessment. bMi was normal in 33.6% of participants, whereas 44.1% were overweight and 21.8% were obese. Higher bMi was correlated with male sex (odds ratio [Or]=0.21), lower education level (Or=0.77) and unhealthy diet (Or=0.57), whereas lower bMi was correlated with lower age (Or=2.05) and unemployment (Or=1.85). to our knowledge, this is the first study to investigate the prevalence of bMi in a healthy Croatian population; our results confirmed the findings of studies conducted in other european countries. Our results highlighted the importance of improving education levels and raising awareness of healthy dietary habits in high-risk groups, i.e. men and older individuals with lower education levels.

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Nutritional Status and Nutrition Quality in Patients with Non-Alcoholic Fatty Liver Disease

Cited by 12 publications

References 32 publications

Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury

Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury

Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice

Are Croatian Blood Donors Obese?

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