Nutritional rickets in Denmark: a retrospective review of children’s medical records from 1985 to 2005

During growth, severe vitamin D deficiency in childhood can result in symptomatic hypocalcaemia and rickets. Despite the suggestion from some studies of a secular increase in the incidence of rickets, this observation may be driven more by changes in population demographics than a true alteration to age, sex and ethnicity-specific incidence rates; indeed rickets remains uncommon overall and is rarely seen in fair-skinned children. Additionally, the impact of less severe vitamin D deficiency and insufficiency has received much interest in recent years, and in this review we consider the evidence relating vitamin D status to fracture risk and bone mineral density (BMD) in childhood and adolescence. We conclude that there is insufficient evidence to support the suggestion that low serum 25-hydroxyvitamin D [25(OH)D] increases childhood fracture risk. Overall, the relationship between 25(OH)D and BMD is inconsistent across studies and across skeletal sites within the same study; however there is evidence to suggest that vitamin D supplementation in children with the lowest levels of 25(OH)D might improve BMD. High quality randomised trials are now required to confirm this benefit.

show abstract

“…Fracture can be the presenting feature of VDD rickets [3,4,6,22,[43][44][45][46][47][48][49]. However it is relatively uncommon.…”

Section: Fracture In Children With Vitamin D Deficiency Ricketsmentioning

confidence: 99%

Vitamin D and skeletal health in infancy and childhood

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Vitamin D deficiency is common among moderately and heavily pigmented immigrants living in Europe and in Pakistani men living in Norway, serious vitamin D deficiency was prevalent, and five times as frequent as in native Norwegian men [46]. Furthermore, vitamin D deficiency is a risk for dark skinned children immigrated to countries far from the equator, like Denmark [47].…”

Section: Vitamin D Statusmentioning

confidence: 99%

Healthy aging and age-adjusted nutrition and physical fitness

Hammar

Östgren

2013

Best Practice & Research Clinical Obstetrics & Gynaecol

View full text Add to dashboard Cite

(154 words)The expected life span is gradually increasing worldwide. For healthy ageing there are a number of options that may be used including healthy dietary and exercise habits. To reduce or prevent obesity certain types of diet may be used that will also reduce the risk of, e.g., cardiovascular disease (CVD). Exercise reduces the risk of diseases like CVD, osteoporosis, some cancers and some mental disturbances. Decreasing a sedentary life style seems at least as important as regular exercise. Exercise can probably be tailored to reduce the risk of CVD and extent of bone loss. To insure adherence, it is important to slowly increase the frequency, duration and intensity of exercise and to find activities that suit the individual. More research has to be done in order to find the ideal modes and doses of exercise and to increase long-term adherence. Both dietary and exercise modification seem to be strong promoters of healthy ageing.Healthy aging and age adjusted nutrition and physical fitness Hammar M, Östgren CJ

show abstract

“…From this cohort of children with rickets, we have also reported clinical and biochemical characteristics and risk factors (7).…”

Section: Introductionmentioning

confidence: 99%

Incidence and prevalence of nutritional and hereditary rickets in southern Denmark

Beck-Nielsen

Brock-Jacobsen²,

Gram

et al. 2009

European Journal of Endocrinology

Self Cite

245

158

View full text Add to dashboard Cite

Objective: To estimate the incidence of nutritional rickets and the incidence and prevalence of hereditary rickets. Design: Population-based retrospective cohort study based on a review of medical records. Methods: Patients aged 0-14.9 years referred to or discharged from hospitals in southern Denmark from 1985 to 2005 with a diagnosis of rickets were identified by register search, and their medical records were retrieved. Patients fulfilling the diagnostic criteria of primary rickets were included. Results: We identified 112 patients with nutritional rickets of whom 74% were immigrants. From 1995 to 2005, the average incidence of nutritional rickets in children aged 0-14.9 and 0-2.9 years was 2.9 and 5.8 per 100 000 per year respectively. Among immigrant children born in Denmark, the average incidence was 60 (0-14.9 years) per 100 000 per year. Ethnic Danish children were only diagnosed in early childhood and the average incidence in the age group 0-2.9 years declined from 5.0 to 2.0 per 100 000 per year during 1985-1994 to 1995-2005. Sixteen cases of hereditary rickets were diagnosed during the study period giving an average incidence of 4.3 per 100 000 (0-0.9 years) per year. The prevalence of hypophosphatemic rickets and vitamin D-dependent rickets type 1 was 4.8 and 0.4 per 100 000 (0-14.9 years) respectively. Conclusions: Nutritional rickets is rare in southern Denmark and largely restricted to immigrants, but the incidence among ethnic Danish children was unexpectedly high. Hereditary rickets is the most common cause of rickets in ethnic Danish children, but nutritional rickets is most frequent among all young children.

show abstract

Nutritional rickets in Denmark: a retrospective review of children’s medical records from 1985 to 2005

Cited by 58 publications

References 33 publications

Vitamin D and skeletal health in infancy and childhood

Vitamin D and skeletal health in infancy and childhood

Healthy aging and age-adjusted nutrition and physical fitness

Incidence and prevalence of nutritional and hereditary rickets in southern Denmark

Contact Info

Product

Resources

About