Nutritional Rickets and Vitamin D Deficiency

Pettifor, John M.

doi:10.1007/978-1-59745-464-3_14

Cited by 3 publications

(3 citation statements)

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“…Until recently, little attention has been paid to the prevalence of rickets in most countries, but it is clear that rickets has been and remains a problem in Northern Asian countries, Middle East and in a number of countries in Africa [18]. A study done in Debre Markos 93% of mothers exposed their infants to sunlight but only 57.9% of them exposed daily [19].…”

Section: Introductionmentioning

confidence: 99%

Knowledge and practice on adequate sunlight exposure of infants among mothers attending EPI unit of Aleta Wondo Health Center, SNNPR, Ethiopia

et al. 2019

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Objective The main objective of this study was to assess knowledge and practice of adequate sunlight exposure of infants among mothers attending EPI unit at Aleta Wondo Health Center, Sidama zone, SNNPR, Ethiopia. Institutional based descriptive cross sectional study design was used. 313 mothers who had under 1 year child and immunization follow-up were selected by simple random sampling technique using immunization registration book as sampling frame. Result Out of 313 respondents identified for the study 98.03% (n = 307) were responded for the interview. From the total respondents 279 (90.9%) of respondents exposed their infants to sunlight but only 62 (22%) of them exposed adequately. From 307 mothers, 191 (62.2%) are knowledgeable about sunlight exposure and 91 (32.6%) of mothers had good practice of exposing their infants to sunlight. Electronic supplementary material The online version of this article (10.1186/s13104-019-4221-4) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Knowledge and practice on adequate sunlight exposure of infants among mothers attending EPI unit of Aleta Wondo Health Center, SNNPR, Ethiopia

et al. 2019

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“…Rickets manifests as a defect in calcification of cartilage matrix at the epiphyseal growth plate due to defective chondrocyte differentia-tion and a delay in mineralization of newly formed osteoid (termed osteomalacia) at the trabecular bone surfaces; and endosteal and peri-osteal surfaces of cortical bone (Pettifor and Thandrayen, 2017). The failure of endochondral calcification results in widening and deforma-tion of the growth plates and subsequent development of visible bony deformities, especially in weight bearing long bones.…”

Section: Definition Of Ricketsmentioning

confidence: 99%

The Roles of Vitamin D and Dietary Calcium in Nutritional Rickets

2019

JALHSS

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The etiology and pathogenesis of nutritional rickets are becoming progressively clearer. Vitamin D deficiency has generally been considered the major or only player in the pathogenesis of nutritional rickets. However, recent research into calcium deficiency has now provided clinicians with reasons to investigate and manage patients with nutritional rickets more appropriately. The important question when assessing cases of nutritional rickets is: "Is it calcium or vitamin D deficiency or both that play a major role in the pathogenesis of the disease"? The case presentation in this review highlights the risk factors, clinical presentation and pathophysiology of nutritional rickets in a young in Baghdad , a city with abundant sunshine throughout the year.

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“…Finger millet grains contain higher levels of minerals like Ca, Mg, and K (Saleh et al, 2013; Devi et al, 2014). Positive calcium content maintains healthy bones (Pettifor, 2004), while potassium prevents the onset of diabetes, renal and cardiovascular diseases (He and MacGregor, 2008). It also has high levels of amino acids like methionine, lysine and tryptophan (Bhatt et al, 2011), and polyphenols (Chandrasekara and Shahidi, 2011; Devi et al, 2014).…”

Section: Nutritional Significancementioning

confidence: 99%

Biofortification in Millets: A Sustainable Approach for Nutritional Security

Alphonse¹,

Ravindhran²

2017

Front. Plant Sci.

109

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Nutritional insecurity is a major threat to the world’s population that is highly dependent on cereals-based diet, deficient in micronutrients. Next to cereals, millets are the primary sources of energy in the semi-arid tropics and drought-prone regions of Asia and Africa. Millets are nutritionally superior as their grains contain high amount of proteins, essential amino acids, minerals, and vitamins. Biofortification of staple crops is proved to be an economically feasible approach to combat micronutrient malnutrition. HarvestPlus group realized the importance of millet biofortification and released conventionally bred high iron pearl millet in India to tackle iron deficiency. Molecular basis of waxy starch has been identified in foxtail millet, proso millet, and barnyard millet to facilitate their use in infant foods. With close genetic-relatedness to cereals, comparative genomics has helped in deciphering quantitative trait loci and genes linked to protein quality in finger millet. Recently, transgenic expression of zinc transporters resulted in the development of high grain zinc while transcriptomics revealed various calcium sensor genes involved in uptake, translocation, and accumulation of calcium in finger millet. Biofortification in millets is still limited by the presence of antinutrients like phytic acid, polyphenols, and tannins. RNA interference and genome editing tools [zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)] needs to be employed to reduce these antinutrients. In this review paper, we discuss the strategies to accelerate biofortification in millets by summarizing the opportunities and challenges to increase the bioavailability of macro and micronutrients.

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Nutritional Rickets and Vitamin D Deficiency

Cited by 3 publications

References 83 publications

Knowledge and practice on adequate sunlight exposure of infants among mothers attending EPI unit of Aleta Wondo Health Center, SNNPR, Ethiopia

Knowledge and practice on adequate sunlight exposure of infants among mothers attending EPI unit of Aleta Wondo Health Center, SNNPR, Ethiopia

The Roles of Vitamin D and Dietary Calcium in Nutritional Rickets

Biofortification in Millets: A Sustainable Approach for Nutritional Security

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