Aim: The aim of the investigation was to evaluate and compare the phytoconstituents and antimicrobial activities of leaf extracts of two species of Acalypha (A. wilkesiana and A. godseffiana). Methodology: The methods employed include manual pulverization of the air-dried leaves and solvent (ethanol) percolation for 72 hrs. The crude extracts were kept in sterile Mc Cartney bottles and stored in the refrigerator 4±2°C. Thereafter, th ey were screened for phytochemical components. Moreover, they were investigated for antimicrobial activities against Bacillus subtilis, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Streptococcus pneumoniae, Staphylococcus aureus, Aspergillus flavus, Candida albicans, and Cryptococcus neoformans. Results: From the results obtained during the study, flavonoid, saponin, phobatanin, tannin and alkaloid were found in both A. wilkesiana and A. godseffiana, steroid was found only in Original Research Article