Nutritional management of cystic fibrosis.

MacDonald, Anita

doi:10.1136/adc.74.1.81

Cited by 71 publications

(35 citation statements)

References 64 publications

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“…All patients received fatsoluble antioxidant and vitamin C supplementation (·-tocopherol: ! 10 years 100 mg daily, 1 10 years 200 mg daily; retinol: 2.5 mg daily; ascorbic acid: 100-200 mg daily) according to international guidelines [22,23]. Children of the control group consisted of 24 formerly hospitalized patients, 13 females and 11 males, mean age 8.33 years (6-12 years), who recovered from their minor illnesses but needed a follow-up blood test.…”

Section: Methodsmentioning

confidence: 99%

Antioxidant Status in Patients with Cystic Fibrosis

et al. 2000

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Background: The aim of the study was to assess the antioxidant status in cystic fibrosis (CF) patients compared to healthy controls. In order to determine the influence of nutrition on the level of the antioxidants, nutrient intake was also monitored in both groups at the time of the antioxidant assessment. Subjects and Methods: The authors measured the serum malondialdehyde levels in children with CF, n = 21; 9 females and 12 males, mean age: 8.71 years (6–12 years) and compared these values to the levels found in age-matched healthy control subjects, n = 24; 13 females and 11 males, mean age: 8.33 years (6–12 years). In order to assess the antioxidant status, catalase and superoxide dismutase activities in washed erythrocytes, glutathione peroxidase activity of heparinized whole blood and serum ascorbic acid, α-tocopherol and retinol levels were measured. Total antioxidant status (TAS) was also tested. The patients with CF received vitamin supplementation in doses prescribed in international guidelines (α-tocopherol: <10 years 100 mg daily, >10 years 200 mg daily, retinol: 2.5 mg daily, ascorbic acid: 100–200 mg daily). Results: Plasma levels of malondialdehyde were significantly higher (p < 0.05), superoxide dismutase activities were significantly lower (p < 0.05) in patients with cystic fibrosis. There were no significant differences in catalase, glutathione peroxidase activities and TAS levels between CF patients and control group. Plasma ascorbic acid, α-tocopherol and retinol levels were within normal limits in both groups. Conclusion: On the basis of the present results this regime failed to provide sufficient antioxidant protection. Therefore, the authors suggest that the daily dose of these antioxidants should be either increased or to administer in parenteral route to patients with severe form of the disease.

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Section: Methodsmentioning

confidence: 99%

Antioxidant Status in Patients with Cystic Fibrosis

et al. 2000

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“…O tecido endócrino do pâncreas é preservado inicialmente, mas com o aumento da idade do paciente, células são perdidas e a glândula começa a ser completamente substituída por tecido fibroso e gordura 30 . Quando o comprometimento atinge a porção endócrina do pâncreas, pode ocorrer intolerância a glicose e diabetes mellitus.…”

Section: Manifestações Gastrintestinaisunclassified

“…Fatores interdependentes, como deterioração da função pulmonar, anorexia, vômitos, insuficiência pan-creática e complicações biliares e intestinais são responsáveis pelo aumento das necessidades energéticas, ingestão diminuída e aumento das perdas atribuídas à inadequação nutricional, com conseqüente perda da massa magra e depressão da função imunológica 30 .…”

Section: Tratamento Nutricionalunclassified

Fibrose cística: uma abordagem clínica e nutricional

et al. 2008

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A fibrose cística é a doença genética letal mais comum em populações caucasianas e é caracterizada por infecções crônicas e recorrentes do pulmão, insuficiência pancreática e elevados níveis de cloro no suor. É uma doença de herança autossômica recessiva causada pela mutação no gene do Regulador da Condutância Transmembrana da Fibrose Cística, que induz o organismo a produzir secreções espessas e viscosas que obstruem os pulmões, o pâncreas e o ducto biliar. Muitos pacientes apresentam insuficiência pancreática, que leva a má-absorção de nutrientes especialmente de proteínas e lipídeos e a complicações gastrintestinais tais como prolapso retal, síndrome da obstrução intestinal, constipação e cirrose hepática. A fibrose cística normalmente é diagnosticada na infância, pelos programas de triagem neonatal ou pelo teste do suor. Devido aos vários sistemas envolvidos e à variabilidade e cronicidade da doença, uma abordagem multidisciplinar é essencial para auxiliar o paciente e sua família a compreenderem a doença e aderirem ao tratamento. A terapia atual da fibrose cística inclui a manutenção do estado nutricional, a remoção das secreções das vias aéreas com fisioterapia e mucolíticos, o uso de antibióticos para prevenção e tratamento de infecções, a prescrição de suplementos energéticos, dietas hiperlípidicas e hiperprotéicas, bem como a suplementação de minerais e vitaminas lipossolúveis. O objetivo deste trabalho foi realizar breve revisão de literatura sobre os aspectos clínicos e nutricionais da fibrose cística.

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“…Most caregivers today agree that the intake of fat should be high for CF patients and recommendations globally vary between 35 and 50 energy percent (65)(66)(67). A recent study has identified a correlation between total daily fat intake expressed in grams and the percentage of recommended daily intake (RDI) (72).…”

Section: Fatmentioning

confidence: 99%

“…Nutritional guidelines have been published in USA (3), UK (65,66) and in Australia current approaches have been published (64).…”

Section: Applying the Recommendationsmentioning

confidence: 99%

Nutritional management in cystic fibrosis

Garemo

Strandvik

1999

Näringsforskning

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Cystic fibrosis (CF) is the most common hereditary fatal disease but the survival rate has improved markedly over the past 30 years. The three main reasons include specialised knowledge by centralisation of medical treatment, improved treatment of the bacterial infections in the lungs and the increased awareness of the importance of nutrition. Different factors, which affect the nutritional status have to be considered when nutritional recommendations in cystic fibrosis are given. These factors are abnormal metabolism, malabsorption and a decreased intake. An ordinary diet with a high mixed fat content including essential fatty acids together with supplement of fat soluble vitamins in water dispersion, are the basic in the nutritional treatment of the disease.

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Nutritional management of cystic fibrosis.

Cited by 71 publications

References 64 publications

Antioxidant Status in Patients with Cystic Fibrosis

Antioxidant Status in Patients with Cystic Fibrosis

Fibrose cística: uma abordagem clínica e nutricional

Nutritional management in cystic fibrosis

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