Nutritional intervention in patients with juvenile systemic lupus erythematosus: protective effect against the increase in fat mass

Abad, Thais Tobaruela Ortiz; Sarni, Roseli Oselka Saccardo; Silva, Simone Guerra Lopes da; Machado, Daniele G.; Souza, Fabíola Isabel Suano de; Len, Cláudio Arnaldo; Terreri, Maria Teresa

doi:10.1007/s00296-018-4031-3

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…A randomized study previously performed in our unit with 43 jSLE patients, to assess the impact of nutritional intervention in lipid metabolism biomarkers and BMI, achieved no satisfactory result in anthropometric measures; these results highlight the complex multifactor pathogenesis of obesity and being overweight in jSLE patients. 25 Inflammation and higher interleukin concentrations might be associated to an increase in total body and core fat. 26 Linear regression showed an inverse independent association between Se concentrations and c-LDL levelswhich was not the case for GPx activity.…”

Section: Discussionmentioning

confidence: 99%

Selenium nutritional status and its association with SLEDAI-2K, HOMA-IR and lipid profile in Juvenile Systemic Lupus Erythematosus patients

Prado

Aires

Souza

et al. 2022

Lupus

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Objectives To assess nutritional status regarding selenium in adolescents with Juvenile Systemic Lupus Erythematosus (jSLE) and analyze possible associations with disease activity, insulin resistance and lipid profile. Methods This was an observational, cross-sectional study of 31 female adolescents with jSLE and 31 healthy female volunteers as a comparison group. We obtained demographic, anthropometric (weight, stature, waist, and neck circumferences), and clinical data (disease activity measured by SLEDAI-2K) from both groups; laboratory data including: lipid profile, plasma selenium, erythrocyte glutathione peroxidase activity (GPx), plasma malondialdehyde (MDA), ultrasensitive C-reactive protein (usCRP), insulin levels, and glycemia (Homeostasis Model Assessment for Insulin Resistance—HOMA-IR). Results Mean age at diagnosis of jSLE group was 15.9±1.7 years, with mean disease duration of 3.6±2.6 years. 48% of patients and controls had below-reference Se levels (≤46mcg/L). GPx was more frequently below reference levels (<4.171U/L) in the jSLE group, compared to controls. A ROC curve was used to assess the power of the variables to discriminate between both groups; insulin (AUC = 0.712; CI 95% 0.584–0.840), waist-to-height ratio (AUC = 0.704; CI 95% 0.572–0.837), and HOMA-IR (AUC = 0.689; CI 95% 0.556–0.822) were the variables with the greatest discriminatory power. Linear regression showed an independent inverse association between Se levels and c-LDL; no such correlation was found for GPx activity. SLEDAI-2 K and HOMA-IR showed no association with levels of Se and GPx activity. Conclusions Approximately, 50% of jSLE adolescents had below reference Se levels. The frequency of inadequate GPx values was higher in patients, compared to controls. There was an independent inverse association between Se and c-LDL levels in both groups; this was not the case for HOMA-IR and SLEDAI-2K. The data show the importance of assessing Se nutritional status in jSLE patients.

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Section: Discussionmentioning

confidence: 99%

Selenium nutritional status and its association with SLEDAI-2K, HOMA-IR and lipid profile in Juvenile Systemic Lupus Erythematosus patients

Prado

Aires

Souza

et al. 2022

Lupus

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“…Abad et al evaluated the impact of nutritional intervention in these patients. The nutritional intervention in a group of adolescents with lupus for less than 9 months decreased their energy consumption and intake of macronutrients such as carbohydrates, total fat, and saturated fat and had a protective effect against the increase in fat mass [38]. Therefore, the control of traditional risk factors, mainly with nutritional guidance and incentive to physical activity, is the rst step towards the prevention of cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Disease activity index is associated with subclinical atherosclerosis in childhood-onset systemic lupus erythematosus

Medeiros

Salomão

Teixeira

et al. 2021

Preprint

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Background: Systemic lupus erythematosus (SLE) is an independent risk factor for cardiovascular events. The present study determined the prevalence of subclinical atherosclerosis in childhood-onset SLE using the carotid intima-media thickness (CIMT) measurement and investigated associations between traditional and nontraditional risk factors for atherosclerosis, such as medications, SLE Disease Activity Index - SLEDAI-2K and SLICC-ACR damage index and CIMT. Methods: Cross-sectional prospective study between 2017-2018. CIMT was assessed by ultrasonography. Data were collected by chart review, nutritional evaluation and laboratory tests and analyzed by Fisher, Wilcoxon-Mann-Whitney tests, multiple linear and log binomial regression. Results: Twenty-eight patients (mean age 13.9 years, SD 3) were enrolled. The prevalence of subclinical atherosclerosis was 32% (95% CI 14.8, 49.4). The mean CIMT was 0.43 ± 0.035 mm. The most common traditional risk factors observed were dyslipidemia (82.1%), uncontrolled hypertension (14.2%), obesity (14.3%), and poor diet (78.6%). Uncontrolled hypertension (p=0.04), proteinuria (p=0.02), estimated glomerular filtration rate <75ml /min/1.73 m2 (p=0.02) and SLEDAI-2K > 5 (P=0.04) were associated with subclinical atherosclerosis. SLEDAI-2K > 5 maintained association with CIMT after adjusting for control variables. Conclusion: Subclinical atherosclerosis is frequently observed in cSLE, mainly in patients with moderate to severe disease activity.

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“…In view of what has been discussed so far, the impact of SLE on quality of life is evident, not to mention the costs, individual and collective, for health that include access to medicines, exams and consultations that can compromise the necessary uninterrupted support [9,37]. In this context, individualized dietary management and nutritional guidelines promote improvements in eating habits that can help control the disease [38]. Modulations in the diet may include caloric deficit, adequate protein supply, reduction of total fats contemplating the supply of omega-3 polyunsaturated fatty acids (PUFA ω-3), supplementation of vitamin A, vitamin D, complex B vitamins, especially folate, B6 and B12, vitamin C, adequacy in the supply of vitamin E, a diet rich in selenium, adequate in calcium and supplementation when necessary, adjusted in sodium and limited in iron.…”

Section: Discussionmentioning

confidence: 99%

Sarcopenia e excesso de peso em mulheres portadoras de lúpus eritematoso sistêmico

Monteiro¹,

Cardoso²,

Oliveira³

et al. 2021

Rev Bras Fisiol Exerc

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Objetivo: Investigar a prevalência de sarcopenia de acordo com as categorias de índice de massa corporal (IMC) em mulheres com lúpus eritematoso sistêmico assistidas por um hospital de ensino de Maceió, Alagoas. Métodos: Análise transversal com pacientes selecionadas por conveniência, que incluiu dados socioeconômicos, demográficos, clínicos, antropométricos e de sarcopenia. A avaliação antropométrica incluiu IMC, circunferências corpóreas, pregas cutâneas, análise de bioimpedância e percentual de gordura. A sarcopenia foi avaliada segundo os critérios diagnósticos propostos pelo European Working Group on Sarcopenia in Older People-EWGSOP (2019), que inclui um protocolo de triagem SARC-F, a força muscular, a quantidade muscular e o desempenho físico. Foi aplicado o teste de qui-quadrado de Pearson, adotando nível de significância de p < 0,05 e intervalo de confiança de 95%. Resultados: 62,8% das mulheres apresentaram excesso de peso, seguidas de 32,5% com eutrofia e 4,6% com desnutrição. Não foi detectada sarcopenia em nossa amostra. Contudo a triagem SARC-F apontou 17,5% possíveis casos de sarcopenia, enquanto 21,4% das pacientes tiveram provável sarcopenia de acordo com o critério de baixa força de preensão manual (FPM). Ainda, uma parcela da amostra apresentou redução de desempenho físico, sem diferenças estatísticas de acordo com as categorias de IMC. Ainda, 66,6% das mulheres com provável sarcopenia e todas aquelas triadas pelo SARC-F para sarcopenia, apresentaram excesso de peso. Conclusão: O desempenho, a força muscular diminuída e o elevado excesso de peso são alertas para a diminuição de funcionalidade muscular, ficando claro a necessidade do cuidado precoce desta população, bem como adaptações do instrumento avaliativo de sarcopenia para o LES.

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Nutritional intervention in patients with juvenile systemic lupus erythematosus: protective effect against the increase in fat mass

Cited by 9 publications

References 25 publications

Selenium nutritional status and its association with SLEDAI-2K, HOMA-IR and lipid profile in Juvenile Systemic Lupus Erythematosus patients

Selenium nutritional status and its association with SLEDAI-2K, HOMA-IR and lipid profile in Juvenile Systemic Lupus Erythematosus patients

Disease activity index is associated with subclinical atherosclerosis in childhood-onset systemic lupus erythematosus

Sarcopenia e excesso de peso em mulheres portadoras de lúpus eritematoso sistêmico

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