Nutritional influences on age-related skeletal muscle loss

Abstract

Age-related muscle loss impacts on whole-body metabolism and leads to frailty and sarcopenia, which are risk factors for fractures and mortality. Although nutrients are integral to muscle metabolism the relationship between nutrition and muscle loss has only been extensively investigated for protein and amino acids. The objective of the present paper is to describe other aspects of nutrition and their association with skeletal muscle mass. Mechanisms for muscle loss relate to imbalance in protein turnover with a number of anabolic pathways of which the mechanistic TOR pathway and the IGF-1-Akt-FoxO pathways are the most characterised.

Sarcopenia prevalence and factors associated with sarcopenia in older people living in a nursing home in Ankara Turkey

“…26 As sufficient amino acid and energy intake is crucial for muscle Table 4 Studies evaluating the prevalence of sarcopenia according to the European Working Group on Sarcopenia in Older People criteria protein synthesis, it is possible that nutritional status contributes to the development of sarcopenia. 43 As a result, screening and improving nutritional status might also be an opportunity for the management of sarcopenia.…”

High-dose ascorbic acid administration improves functional recovery in rats with spinal cord contusion injury

“…10,12,19 One of the vital functions of AA is to clear free radicals, therefore exerting protective effect in various injuries. 12 Therefore, AA has been used for the treatment of many diseases, such as cardiovascular, digestive, respiratory, musclar, immune dysfunction, urogenital and, importantly, neurological diseases.…”

“…In addition, improved behavioral function of the rats required not only the recovery of damaged neural tissue but also the improved motion of joints, muscle strength and coordination of the limbs. Given the multiple roles of AA, especially its protective roles for muscle loss and damage, 19 immune dysfunction and peripheral nervous system and cardiovascular damage, the improved behavioral function of SCI rats following high-dose AA administration may be combination of these effects and the reduced necrosis at the injury site. Nevertheless, there might be additional mechanisms that contribute to the improved behavioral function that require further investigation.…”

Challenges in Treatment of Obesity in the Elderly

“…In addition, there is a loss of muscle fibres and of the amount of muscle mass (more marked in the lower limbs), the mitochondrial function is impaired, telomeres are shortened and the expression of inflammatory cytokines increases [26]. The smaller amount and size of muscle fibres translates into a loss of muscle strength and functional capacity, which deteriorate the quality of life, increase the risk of disability, morbidity and mortality and increase the risk of fragility, falls and dependence [27].…”