Background: Despite the several studies evaluated the association between patterns of beverage consumption with different components of quality of life separately, the findings are controversial. In addition, none of them examined all components of quality of life together in relation to patterns of beverage consumption. Therefore, this study was conducted to identify the association between healthy beverage index (HBI) and quality of life among overweight and obese women. Methods: For this cross-sectional study, 210 obese and overweight women were chosen from health centers in Tehran, Iran. Using reliable and verified standard protocols, data on beverage intake, socio-demographic, physical activity, and anthropometric variables were assessed. Based on past studies, the predetermined HBI was estimated. Serum samples were used to determine biochemical characteristics. Quality of life was assessed using SF-36 questionnaires.Results: There was a significant association between total QoL score with T2 tertile of HBI in model 2 adjustment (β: 13.11, 95% CI: 1.52, 24.69, P-value= 0.027). general health had a significant negative association with T2 (β: -5.83; 95% CI: -11.48, -0.18; P-value= 0.043) and T3 (β: -6.20; 95% CI: -12.37, -0.03; P-value= 0.049). Women with more adherence of HBI, have the high physical functioning score and there was a significant upward trend with the movement from the second to the third tertile (7.74 vs 0.62) (P-trend=0.036). There was a significant positive association between mental health with T3 of HBI (β: 4.26; 95% CI: 1.51, 5.98; P-value= 0.015) and a significant increasing trend was observed with increasing tertiles (P-trend= 0.045).Conclusion: In conclusion, there is a significant association between total QoL score and its components with HBI among overweight and obese women. However, additional well-designed studies are needed to confirm these findings.