Nutritional genomics in practice: Where do we begin?

DeBusk, Ruth; Fogarty, Colleen; Ordovas, José M.; Kornman, Kenneth S.

doi:10.1016/j.jada.2005.01.002

Cited by 100 publications

(67 citation statements)

References 25 publications

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“…The successful application of nutritional genomics necessitates cohesive action from multiple professionals from different fields working across the spectrum from 'bench to bed' in research, education and healthcare environments. Previous research has addressed the opportunities and barriers relating to genetics and genomics among various workforces including public health, medicine, primary care, nursing, pharmacy, occupational therapy and dietetics (Chen and Goodson 2007;Emery et al 1999;Kirk et al 2008;Ferro et al 2012;Kyler and Thomas 2000;DeBusk et al 2005). One group of health professionals who will be involved in the application of nutritional genomics are dietitians, who have expertise in biomedical and nutritional sciences and are well positioned to translate and deliver health messages to the public.…”

Section: Introductionmentioning

confidence: 99%

The application of genetics and nutritional genomics in practice: an international survey of knowledge, involvement and confidence among dietitians in the US, Australia and the UK

et al. 2013

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As a result of expanding scientific understanding of the interplay between genetics and dietary risk factors, those involved in nutritional management need to understand genetics and nutritional genomics in order to inform management of individuals and groups. The aim of this study was to measure and determine factors affecting dietitians' knowledge, involvement and confidence in genetics and nutritional genomics across the US, Australia and the UK. A cross-sectional study was undertaken using an online questionnaire that measured knowledge and current involvement and confidence in genetics and nutritional genomics. The questionnaire was distributed to dietitians in the US, Australia and the UK using email lists from the relevant professional associations. Data were collected from 1,844 dietitians who had practiced in the previous 6 months. The main outcomes were knowledge of genetics and nutritional genomics and involvement and confidence in undertaking clinical and educational activities related to genetics and nutritional genomics. Mean scores for knowledge, involvement and confidence were calculated. Analysis of variance and v 2 analysis were used to compare scores and frequencies. Multivariate linear regression was used to determine predictors of high scores. The results demonstrated significant differences in involvement (p \ 0.001) and confidence (p \ 0.001) but not knowledge scores (p = 0.119) between countries. Overall, dietitians reported low levels of knowledge (mean knowledge score 56.3 %), involvement (mean number of activities undertaken 20.0-22.7 %) and confidence (mean confidence score 25.8-29.7 %). Significant relationships between confidence, involvement and knowledge were observed. Variables relating to education, experience, sector of employment and attitudes were also significantly associated with knowledge, involvement and confidence. Dietitians' knowledge, involvement and confidence relating to genetics and nutritional genomics remain low and further investigation into factors contributing to this is required.

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Section: Introductionmentioning

confidence: 99%

The application of genetics and nutritional genomics in practice: an international survey of knowledge, involvement and confidence among dietitians in the US, Australia and the UK

et al. 2013

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“…Esta recente ciência tem como objetivo principal o estabelecimento de dietas personalizadas, com base no genótipo, para a promoção da saúde e a redução do risco de doenças crônicas não transmissíveis, como as cardiovasculares, o câncer, o diabetes, entre outras 6,7 .…”

Section: N T R O D U ç ã Ounclassified

“…Indivíduos com esse SNP parecem necessitar de recomendações aumentadas de ácido fólico. Além disso, polimorfismo no gene APOA1, principal apoproteína da HDL (lipoproteína de alta densidade), pode influenciar a forma pela qual os níveis plasmáticos dessa lipoproteína variam em função do consumo de ácidos graxos poliinsaturados 6 . Do ponto de vista tecnológico, o surgimento da nutrigenômica foi favorecido pelo impressionante desenvolvimento das ferramentas ômicas ocorrido na última década, muito em parte devido ao Projeto Genoma Humano 9,14 .…”

Section: N T R O D U ç ã Ounclassified

Nutrição no pós-genoma: fundamentos e aplicações de ferramentas ômicas

2008

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Após seqüenciamento do genoma humano, os estudos genômicos têm se voltado à elucidação das funções de todos os genes, bem como à caracterização de suas interações com fatores ambientais. A nutrigenômica surgiu no contexto do pós-genoma humano e é considerada área-chave para a nutrição nesta década. Seu foco de estudo baseia-se na interação gene-nutriente. Esta ciência recente tem como objetivo principal o estabelecimento de dietas personalizadas, com base no genótipo, para a promoção da saúde e a redução do risco de doenças crônicas não transmissíveis como as cardiovasculares, o câncer, o diabetes, entre outras. Nesse contexto, é fundamental a aplicação na área de nutrição das ferramentas de genômica funcional para análise do transcritoma (transcritômica), do proteoma (proteômica) e do metaboloma (metabolômica). As aplicabilidades dessas metodologias em estudos nutricionais parecem ilimitadas, pois podem ser conduzidas em cultura de células, modelos de experimentação em animais, estudos pré-clinicos e clínicos. Tais técnicas apresentam potencial para identificar biomarcadores que respondem especificamente a um determinado nutriente ou composto bioativo dos alimentos e para estabelecer as melhores recomendações dietéticas individuais para redução do risco das doenças crônicas não transmissíveis e promoção da saúde.

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“…Experimental data demonstrated that environment and foods could regulate gene expression and structure [6]. Food constituents and nutrients may induce the change of structure and function of genes and may be able to prevent or cause speciic diseases; these new areas of study are called nutrigenomics and nutrigenetics [7]. Nutrigenomics aims at relating in the population the efects of certain foods on human health on the basis of genetic predisposition.…”

Section: Introductionmentioning

confidence: 99%

The Mediterranean Diet in the Prevention of Degenerative Chronic Diseases

Valle¹,

Cacciatore²,

Farinaro³

et al. 2017

Superfood and Functional Food - The Development of Superfoods and Their Roles as Medicine

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Degenerative chronic diseases are a problem related to the aging phenomenon of industrialized countries due to the increase of risk factors and related comorbidity such as overweight, obesity, metabolic syndrome, diabetes, hypertension and hyperlipidemia with a consequent increased risk of cardiovascular disease (CVD) and cancer. Moreover, the signiicant reduction of physical activity in daily life and the huge growth in food availability have considerably increased the risk of such diseases. Particular atention should be paid to primary prevention by means of health strategies based on improvement in lifestyle intervention such as implementation of Mediterranean diet and promotion of physical activity programs. In this chapter, the protective efect of Mediterranean diet and the role of certain foods and/or their constituents are analyzed; the possible mechanisms by which Mediterranean diet is efective in the prevention of cardiovascular and other chronic diseases are presented, in particular the efects exerted by antioxidants, polyphenols, ibers, unsaturated faty acids, and alcohol. The genetic revolution in the past decades has produced new ields of study where the interaction between foods, nutrients, and our genetic makeup is investigated. The relationship between nutrigenetics and nutrigenomics and the Mediterranean diet are the future area that research should discover.

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Nutritional genomics in practice: Where do we begin?

Cited by 100 publications

References 25 publications

The application of genetics and nutritional genomics in practice: an international survey of knowledge, involvement and confidence among dietitians in the US, Australia and the UK

The application of genetics and nutritional genomics in practice: an international survey of knowledge, involvement and confidence among dietitians in the US, Australia and the UK

Nutrição no pós-genoma: fundamentos e aplicações de ferramentas ômicas

The Mediterranean Diet in the Prevention of Degenerative Chronic Diseases

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