Nutritional depletion in relation to mortality in patients with chronic respiratory insufficiency treated with long-term oxygen therapy

Tóth, Štefan; Tkáčová, Ružena; Matula, Pavol; Stubna, J

doi:10.1007/s00508-004-0226-6

Cited by 18 publications

(10 citation statements)

References 24 publications

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“…The excluded 181 studies had no relative outcomes, insufficient information, and means or standard deviations comparison for BMI. On more detailed review, an additional 14 papers were excluded for the following reasons: BMI classification was not according to WHO [16]–[21]; participant was without COPD at baseline [22]–[26]; or data was unavailable [27]–[29]. We finally included 22 studies in our systematic review and meta-analysis [30]–[51].…”

Section: Resultsmentioning

confidence: 99%

Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease: A Meta-Analysis

Cao

Wang²,

Wang³

et al. 2012

PLoS ONE

185

156

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BackgroundThe association between body mass index (BMI) and mortality in patients suffering from chronic obstructive pulmonary disease (COPD) has been a subject of interest for decades. However, the evidence is inadequate to draw robust conclusions because some studies were generally small or with a short follow-up.MethodsWe carried out a search in MEDLINE, Cochrane Central Register of Controlled Trials, and EMBASE database for relevant studies. Relative risks (RRs) with 95% confidence interval (CI) were calculated to assess the association between BMI and mortality in patients with COPD. In addition, a baseline risk-adjusted analysis was performed to investigate the strength of this association.Results22 studies comprising 21,150 participants were included in this analysis. Compared with patients having a normal BMI, underweight individuals were associated with higher mortality (RR = 1.34, 95% CI = 1.01–1.78), whereas overweight (RR = 0.47, 95% CI = 0.33–0.68) and obese (RR = 0.59, 95% CI = 0.38–0.91) patients were associated with lower mortality. We further performed a baseline risk-adjusted analysis and obtained statistically similar results.ConclusionOur study showed that for patients with COPD being overweight or obese had a protective effect against mortality. However, the relationship between BMI and mortality in different classes of obesity needed further clarification in well-designed clinical studies.

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Section: Resultsmentioning

confidence: 99%

Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease: A Meta-Analysis

Cao

Wang²,

Wang³

et al. 2012

PLoS ONE

185

156

View full text Add to dashboard Cite

show abstract

“…16 Hemoglobin is a major carrier of oxygen and two previous studies showed influence of anemia on survival in patients with severe airflow obstruction 15 and with chronic hypoxemia. 12 However, the values of hemoglobin (Hb) and hematocrit (Htc) associated with higher mortality have not been established. Anemia is a potentially modifiable prognostic factor and we will test the hypothesis that lower values of Hb and/or Htc negatively influence survival and intend to identify the cut-off points associated with higher mortality in patients using LTOT.…”

Section: Introductionmentioning

confidence: 99%

Potentially modifiable predictors of mortality in patients treated with long-term oxygen therapy

Lima

Coleta

Tanni

et al. 2011

Respiratory Medicine

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“…Alteration in body composition is an extrapulmonary effect of COPD that has been extensively investigated. Low body weight in COPD patients is an independent predictor of mortality [7,8,9], while a low skeletal muscle mass may be an even better predictor than the body mass index [BMI; weight in kg/(height in m) 2 ] [10,11]. In addition, low body weight and muscle mass have been associated with worse health status [12,13].…”

Section: Introductionmentioning

confidence: 99%

Changes in Body Composition in Patients with Chronic Obstructive Pulmonary Disease: Do They Influence Patient-Related Outcomes?

et al. 2013

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Aims: The follow-up of the ECLIPSE study, a prospective longitudinal study to identify and define parameters that predict disease progression over 3 years in chronic obstructive pulmonary disease (COPD), allows the examination of the effect of body composition changes on COPD-related outcomes. Methods: Body composition and health status were established in 2,115 COPD patients, 327 smoking and 239 nonsmoking controls at baseline and 3 years, while mortality was recorded in year 2 and 3 in the COPD patients. Associations between fat free mass index (FFMI) and fat mass index (FMI) changes to deterioration in health status and mortality were determined. Results: Change in FFMI and FMI over 3 years was small and comparable between the groups. Underweight and obese patients had the worst health status. Worsening health status was associated with FFMI decrease in underweight patients and FMI increase in overweight/obese patients. While overweight patients had the lowest mortality, FFMI or FMI decrease was associated with a higher mortality. Conclusion: Changes in body composition over 3 years were small and comparable in COPD patients and control subjects. Nevertheless, muscle mass decline in underweight and fat mass increase in overweight/obese patients is associated with worsening health status. Overweight is associated with decreased mortality, but muscle mass and fat mass decline are detrimental for mortality.

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Nutritional depletion in relation to mortality in patients with chronic respiratory insufficiency treated with long-term oxygen therapy

Abstract: This study suggests that nutritional status is closely linked with prognosis in patients with chronic respiratory insufficiency treated with domiciliary LTOT: low BMI, low plasma cholesterol and low albumin are related to worse 2-year survival in such patients.

Cited by 18 publications

References 24 publications

Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease: A Meta-Analysis

Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease: A Meta-Analysis

Potentially modifiable predictors of mortality in patients treated with long-term oxygen therapy

Changes in Body Composition in Patients with Chronic Obstructive Pulmonary Disease: Do They Influence Patient-Related Outcomes?

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