Nutritional Constituent of Black Pepper as Medicinal Molecules: A Review

Goswami, T.K.

doi:10.4172/scientificreports.129

Cited by 30 publications

(22 citation statements)

References 11 publications

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“…Being one of the best natural antioxidant, black pepper is used as an important spice to prevent oxidation and off flavour of food items. Apart from this, the pharmacological properties of black pepper make it a health-improving natural medicine (Meghwal and Goswami 2012). Black pepper also occupies key phylogenetic position by being a perennial vine that belongs to the family Piperaceae of magnoliids, the basal angiosperms.…”

Section: Introductionmentioning

confidence: 99%

Unravelling the complexity of microRNA-mediated gene regulation in black pepper (Piper nigrum L.) using high-throughput small RNA profiling

2015

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Analysis of high-throughput small RNA deep sequencing data, in combination with black pepper transcriptome sequences revealed microRNA-mediated gene regulation in black pepper ( Piper nigrum L.). Black pepper is an important spice crop and its berries are used worldwide as a natural food additive that contributes unique flavour to foods. In the present study to characterize microRNAs from black pepper, we generated a small RNA library from black pepper leaf and sequenced it by Illumina high-throughput sequencing technology. MicroRNAs belonging to a total of 303 conserved miRNA families were identified from the sRNAome data. Subsequent analysis from recently sequenced black pepper transcriptome confirmed precursor sequences of 50 conserved miRNAs and four potential novel miRNA candidates. Stem-loop qRT-PCR experiments demonstrated differential expression of eight conserved miRNAs in black pepper. Computational analysis of targets of the miRNAs showed 223 potential black pepper unigene targets that encode diverse transcription factors and enzymes involved in plant development, disease resistance, metabolic and signalling pathways. RLM-RACE experiments further mapped miRNA-mediated cleavage at five of the mRNA targets. In addition, miRNA isoforms corresponding to 18 miRNA families were also identified from black pepper. This study presents the first large-scale identification of microRNAs from black pepper and provides the foundation for the future studies of miRNA-mediated gene regulation of stress responses and diverse metabolic processes in black pepper.

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Section: Introductionmentioning

confidence: 99%

Unravelling the complexity of microRNA-mediated gene regulation in black pepper (Piper nigrum L.) using high-throughput small RNA profiling

2015

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“…Piperine is a major alkaloids present in black pepper [2,5,23]. It is the naturally occurring alkaloid that gives the spice and biting taste [24].…”

Section: Introductionmentioning

confidence: 99%

“…Black pepper used in various fields such as food processing [4,5], and pharmaceutical industry [3,6], also the uses are increasing steadily due to its recognition as an important source of natural compounds. Black pepper is one of the plants with medicinal components along with appreciable levels of several other functional components having health promoting properties [7,8], particularly as anti-microbial [9], anti-inflammatory [3,10], anti-mutagenic [11], a free-radical scavenger [1,7,12], immunomodulator [13], anti-tumor [6,14], anti-depressant [15], anti-apoptotic [16], anti-metastatic [17], anti-thyroid [18], immunostimulator [19], anti-diarrheal and anti-spasmodic [20].…”

Section: Introductionmentioning

confidence: 99%

Synthesising a novel derivatives of piperine from black pepper (Piper nigrum L.)

2015

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Black pepper (Piper nigrum L.) has gained a global consideration because of its volume in the spice industry. This plant has shown great potential for having medical applications and novel biologically active compounds. In black pepper, natural lipophilic amide piperine was isolated. Piperine was isolated from the fruit using glacial acetic acid as solvent. After isolation and characterization of piperine were done, then it is used to prepare new and novel derivatives of piperine through the experimental procedure. The derivatives of piperine were synthesized by condensation of piperic acid with different substituted aromatic amines, to make a new derivative of piperine, such as ((2E, 4E)-5-(1,3-benzodioxol-5-yl)-N-(1,3-benzothiazol-2-yl)penta-2,4-dienamide) and a novel derivative ((2E, 4E)-5-(1,3-benzodioxol-5-yl)-N-(1,3-benzothiazol-2-yl)penta-2,4-dienehydrazide). The structure of piperine and the derivatives were elucidated through a combination of spectrometric techniques, including ultraviolet spectrophotometer, Mass spectrometry Fourier transform infrared spectroscopy, proton nuclear magnetic resonance.

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“…nutritional alters, infection, inflammation and other chronic diseases. Natural products NPs are characteristically derived secondary metabolites; isolated from organisms (such as bacteria, fungi, protozoans, animals as well as plant material which possess leaves, fruit, seed, bark, root, stem, or other parts of the plants entirely that contain as active ingredients such as juices, gums, fatty oils, essential oils and many other substances of these plants for example Nigella Sativa L. [42] and Black Pepper oils [47] which contain phytochemical compound is thymoquinone had been proven in enhancing the circulating bioavailability of several drugs and nutrients and it is quiet challenging to obtain a satisfactory bioavailability [48]. So, the following experiments had been design to prove the Nigella Sativa L.oils use as a novel delivery system to improve the bioavailability of Curcumin compared with black pepper in animal model and volanuteer human.…”

Section: Experimental and Clinical Studiesmentioning

confidence: 99%