Nutritional consequences and nutrition therapy in Crohn's disease

Hébuterne, Xavier; Filippi, Jérôme; Al-Jaouni, Rima; Schneider, Stéphane

doi:10.1016/s0399-8320(09)73159-8

Cited by 33 publications

(31 citation statements)

References 51 publications

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“…These include vitamin D activation and deactivation processes mediated by cytochromes (CYP2R1 and CYP27B1 for activation and CYP24A1 for deactivation), its transportation in blood and across cell membranes mediated by proteins (DBP, megalin/cubulin) and its genetic effects mediated by cellular complexes such as VDR/RXR and transcriptional activators/repressors 81 . In addition, genetic polymorphisms 25, 73, 82 and disease related impairments (altered protein turnover 83 , protein-losing enteropathies 84, 85 and dysbiosis 86, 87 ) might also modify the association between IBD and serum vitamin D levels.…”

Section: Discussionmentioning

confidence: 99%

Association Between Inflammatory Bowel Disease and Vitamin D Deficiency

Pinto

Pietropaoli

Chandar

et al. 2015

Inflammatory Bowel Diseases

202

118

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Background Vitamin D plays a role in several immune-mediated diseases, but its association with inflammatory bowel disease (IBD) is unclear. We conducted a systematic review and meta-analysis to assess the association between IBD and vitamin D deficiency. Methods We searched electronic databases from inception to December 2014 for observational studies reporting the presence of vitamin D deficiency (defined as serum 25-hydroxycholecalciferol [25(OH)D] level of ≤20 ng/ml) in IBD patients and having a control group without IBD. Odds ratios (OR) were combined using a random effects model. Meta-regression was performed using latitude as a moderator. Study quality was assessed using the Newcastle-Ottawa scale. Results Out of 816 citations, 14 eligible studies were identified, comprising 1891 participants (938 IBD cases and 953 controls). Meta-analysis showed that patients with IBD had 64% higher odds of vitamin D deficiency when compared to controls (OR = 1.64; 95% CI: 1.30, 2.08; I2 = 7%; p < 0.0001). UC patients had more than double the odds of vitamin D deficiency when compared to normal controls (OR = 2.28; 1.18, 4.41; I2 = 41%; p=0.01). Latitude did not influence the association between IBD and vitamin D deficiency (p = 0.34). Generalizability of our results might be limited as we summarized unadjusted ORs, due to non-availability of adjusted ORs in individual studies. Conclusions IBD is significantly associated with having higher odds of vitamin D deficiency. Well-designed RCTs and longitudinal studies are needed to further clarify the role of vitamin D in IBD pathogenesis and its therapy.

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Section: Discussionmentioning

confidence: 99%

Association Between Inflammatory Bowel Disease and Vitamin D Deficiency

Pinto

Pietropaoli

Chandar

et al. 2015

Inflammatory Bowel Diseases

202

118

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“…The potential mechanisms of altered body composition in IBD are multiple. Reduced caloric intake may play a role, often in the context of symptomatic disease and reduced appetite . The secretion of pro‐inflammatory cytokines may alter energy metabolism, protein turnover and energy substrate utilisation .…”

Section: Discussionmentioning

confidence: 99%

Systematic review: body composition in adults with inflammatory bowel disease

Bryant

Trott

Bartholomeusz

et al. 2013

Aliment Pharmacol Ther

146

117

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“…Another study reported that iron, folate, and vitamin B 12 are more readily deficient in patients with CD (25-69%) than in those with UC (1-32%) [16]. Another study recorded that in addition to deficiencies in those elements, calcium, magnesium, zinc, vitamin A, and vitamin D deficiencies occurred in patients who presented with IBD [17]. Ironically, deficiencies of selenium, copper, and chromium are quite rare in IBD patient at the presenting stage except in those for whom central parenteral nutrition therapies are required [18].…”

Section: Discussionmentioning

confidence: 99%

Pre-diagnostic Clinical Presentations and Medical History Prior to the Diagnosis of Inflammatory Bowel Disease in Children

Kwon

Kim

2013

Pediatr Gastroenterol Hepatol Nutr

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PurposeThe clinical presentations of inflammatory bowel disease (IBD) prior to diagnosis are so diverse or vague that many of them waste time before final diagnosis. This study was undertaken to know the medical history of the pediatric patients until the final diagnosis could be reached.MethodsThe medical records of all pediatric patients who were diagnosed with IBD (Crohn's disease [CD] in 14 children, ulcerative colitis [UC] in 17) during the last 13 years were reviewed. We investigated the length of the diagnostic time lag, chief clinical presentation, and any useful laboratory predictor among the routinely performed examinations. Indeterminate colitis was not included.ResultsThe mean ages of children at the final diagnosis was similar in both diseases. As for the pre-clinical past history of bowel symptoms in CD patients, 5 were previously healthy, 9 had had 1-3 gastrointestinal (GI) symptoms, weight loss, bloody stool, anemia and rectal prolapse. With UC, 9 were previously healthy, 8 had had 1-3 GI symptoms, bloody stool, anorexia. The average diagnostic time lag with CD was 3.36 months, and with UC 2.2 months. Body mass index (BMI) and the initial basic laboratory data (white blood cell, hemoglobin, mean corpuscular volume, serum albumin, and serum total protein) were lower in CD, statistically significant only in BMI.ConclusionIBD shows diverse clinical symptoms before its classical features, making the patients waste time until diagnosis. It is important to concern possibility of IBD even in the mildly sick children who do not show the characteristic symptoms of IBD.

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Nutritional consequences and nutrition therapy in Crohn's disease

Cited by 33 publications

References 51 publications

Association Between Inflammatory Bowel Disease and Vitamin D Deficiency

Association Between Inflammatory Bowel Disease and Vitamin D Deficiency

Systematic review: body composition in adults with inflammatory bowel disease

Pre-diagnostic Clinical Presentations and Medical History Prior to the Diagnosis of Inflammatory Bowel Disease in Children

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