Systematic review: body composition in adults with inflammatory bowel disease

Bryant, Robert V.; Trott, M. J.; Bartholomeusz, Francis Dylan; Andrews, Jane M.

doi:10.1111/apt.12372

Cited by 146 publications

(150 citation statements)

References 113 publications

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“…Symptoms of acute disease (such as diarrhea, malabsorption, and decreased dietary intake) and the presence of chronic inflammation may lead to malnutrition and altered body composition as well. Bryan et al recently reviewed the corresponding literature comparing the body composition of IBD patients and healthy controls (27). However, the number of patients was relatively low in the studies included; besides, the methodology of the measurements was heterogeneous as they used different DEXA and BIA instruments.…”

Section: Discussionmentioning

confidence: 99%

Malnutrition risk questionnaire combined with body composition measurement in malnutrition screening in inflammatory bowel disease

Csontos¹,

Molnár²,

Piri³

et al. 2016

Rev Esp Enferm Dig

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The purpose of malnutrition screening is to predict the probability of a worse outcome due to nutritional factors. The Malnutrition Universal Screening Tool (MUST) can be used for screening in inflammatory bowel disease (IBD); however, it does not provide details about body composition. Our aim was to assess the body composition and combine this with the MUST method to screen risk of malnutrition and sarcopenia. A total of 173 IBD outpatients were enrolled in this cross-sectional study. The MUST scale indicated 21.4% of IBD patients to be at risk of malnutrition. A risk of sarcopenia was detected in 27.7%. However, one third of these patients were not considered to be at risk by their MUST score. Furthermore, Crohn's disease (CD) patients had a strongly unfavorable fat-free mass index (FFMI) value compared to ulcerative colitis (UC) patients, and these differences were significant among men (FFMI: 18.62 ± 2.16 vs 19.85 ± 2.22, p = 0.02, in CD and UC males, respectively). As sarcopenia is a relevant prognostic factor, the MUST method should be expanded to include body composition analysis to detect more IBD patients at risk of malnutrition and sarcopenia in order to start their nutritional therapy immediately.

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Section: Discussionmentioning

confidence: 99%

Malnutrition risk questionnaire combined with body composition measurement in malnutrition screening in inflammatory bowel disease

Csontos¹,

Molnár²,

Piri³

et al. 2016

Rev Esp Enferm Dig

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“…hypertriglyceridemia, change in LDL composition, increase in HDL), and weight gain, mainly at the expense of increased abdominal and visceral fat. 25 Since anti-TNF therapy controls the inflammatory state and induces remission in moderate to severe CD, it is possible that after this intervention an increase in body weight, LM and PA of these patients may be observed. In this context, our study was designed to evaluate the impact of anti-TNFα therapy on body composition and PA in patients with active CD.…”

Section: Introductionmentioning

confidence: 99%

Impact of biological therapy on body composition of patients with Chron's disease

Santos

Malaguti

Lucca

et al. 2017

Rev. Assoc. Med. Bras.

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“…[13][14][15] Even in patients with IBD, there is a trend to equivalent or even higher fat mass and/or body mass index compared with age-and sex-matched HC in contrast with the archetypal, malnourished and cachectic IBD patient of times past. 16 Research into sleep quality and physical activity is hampered in this field by the difficulties of accurate, objective measurement, the expense and inconvenience of tools such as polysomnography and for the purposes of clinical applicability, the need to measure these in a habitual context with subjects performing their normal daily activities. Triaxial accelerometers overcome many if not all of these obstacles and strongly correlate with 'gold standard' testing such as formal polysomnography.…”

Section: Introductionmentioning

confidence: 99%

Sleep and physical activity measured by accelerometry in Crohn's disease

Langenberg

Papandony

Gibson

2015

Aliment Pharmacol Ther

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SummaryBackgroundSleep and physical activity are inherent to human living, yet appear affected by Crohn's disease (CD), resulting in fatigue and disability.AimTo objectively assess sleep quality and physical activity and their associations using accelerometers, comparing CD vs. matched healthy control (HC) subjects.MethodsExactly 49 CD and 30 HC subjects completed surveys encompassing self‐reported fatigue and sleep quality, pathology testing and wore an accelerometer for 7 days, measuring physical activity and sleep. In this cross‐sectional observational study, per‐group comparisons were performed and in CD, factors associated with reduced activity and/or sleep quality were assessed via multivariate analyses.ResultsRegarding physical activity, CD subjects overall performed less total accelerometer counts (median 1.3 × 106 vs. 2.0 × 106), were more sedentary (97.7% vs. 96.2%) and completed fewer bouts of moderate‐vigorous intensity exercise (1.0 vs. 5.0, each P < 0.01 (Mann–Whitney) than HC over 7 days. Factors associated with poor physical activity in CD included elevated serum CRP (OR = 22.6), lower vitamin D3 (OR = 13.1) and longer disease duration (OR = 1.2 per year, each P < 0.05). Regarding sleep, the CD group had similar total sleep time (median 458 vs. 447 min, P = 0.56), but more awakenings post‐sleep onset (22 vs. 11, P = 0.01). Factors associated with severe sleep dysfunction in CD included lower haemoglobin (OR = 6.7) concurrent anti‐TNF (OR = 6.5, each P < 0.05) and opioid therapy (OR = 6.6, P = 0.09).ConclusionUtilising objective measurement in a habitual context over 7 days, patients with Crohn's disease exhibited poorer sleep quality and less physical activity than well‐matched healthy controls.

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Systematic review: body composition in adults with inflammatory bowel disease

Abstract: SUMMARY BackgroundThere is a paucity of data on body composition in patients with inflammatory bowel disease (IBD). Alterations of fat and muscle may affect bone health, muscle performance, quality of life (QoL) and overall morbidity.

Cited by 146 publications

References 113 publications

Malnutrition risk questionnaire combined with body composition measurement in malnutrition screening in inflammatory bowel disease

Malnutrition risk questionnaire combined with body composition measurement in malnutrition screening in inflammatory bowel disease

Impact of biological therapy on body composition of patients with Chron's disease

Sleep and physical activity measured by accelerometry in Crohn's disease

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