Nutritional Cognitive Neuroscience: Innovations for Healthy Brain Aging

Zamroziewicz, Marta K.; Barbey, Aron K.

doi:10.3389/fnins.2016.00240

Cited by 59 publications

(47 citation statements)

References 92 publications

(97 reference statements)

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“…The research conducted in the present study is unique and complements prior research conducted from this cohort (Zamroziewicz & Barbey, 2016, 2018Zamroziewicz et al, 2015Zamroziewicz, Paul, et al, 2017a, 2016aZamroziewicz, Talukdar, Zwilling, & Barbey, 2017b;Zamroziewicz, Zwilling, & Barbey, 2016b). The research conducted in the present study is unique and complements prior research conducted from this cohort (Zamroziewicz & Barbey, 2016, 2018Zamroziewicz et al, 2015Zamroziewicz, Paul, et al, 2017a, 2016aZamroziewicz, Talukdar, Zwilling, & Barbey, 2017b;Zamroziewicz, Zwilling, & Barbey, 2016b).…”

Section: Study Participantsmentioning

confidence: 58%

Nutrient biomarkers shape individual differences in functional brain connectivity: Evidence from omega‐3 PUFAs

Talukdar

Zamroziewicz

Zwilling

et al. 2018

Human Brain Mapping

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A wealth of neuroscience evidence demonstrates that diet and nutrition play an important role in structural brain plasticity, promoting the development of gray matter volume and maintenance of white matter integrity across the lifespan. However, the role of nutrition in shaping individual differences in the functional brain connectome remains to be well established. We therefore investigated whether nutrient biomarkers known to have beneficial effects on brain structure (i.e., the omega‐3 polyunsaturated fatty acids; ω‐3 PUFAs), explain individual differences in functional brain connectivity within healthy older adults (N = 96). Our findings demonstrate that ω‐3 PUFAs are associated with individual differences in functional connectivity within regions that support executive function (prefrontal cortex), memory (hippocampus), and emotion (amygdala), and provide key evidence that the influence of these regions on global network connectivity reliably predict general, fluid, and crystallized intelligence. The observed findings not only elucidate the role of ω‐3 PUFAs in functional brain plasticity and intelligence, but also motivate future studies to examine their impact on psychological health, aging, and disease.

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Section: Study Participantsmentioning

confidence: 58%

Nutrient biomarkers shape individual differences in functional brain connectivity: Evidence from omega‐3 PUFAs

Talukdar

Zamroziewicz

Zwilling

et al. 2018

Human Brain Mapping

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“…Nutrition is a promising target for intervention efforts to support healthy brain aging (Zamroziewicz and Barbey, 2016). Accumulating evidence indicates that particular nutrients may slow or prevent aspects of age-related cognitive decline by targeting specific features of brain aging.…”

Section: Introductionmentioning

confidence: 99%

Parahippocampal Cortex Mediates the Relationship between Lutein and Crystallized Intelligence in Healthy, Older Adults

Zamroziewicz

Paul

Zwilling

et al. 2016

Front. Aging Neurosci.

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Introduction: Although, diet has a substantial influence on the aging brain, the relationship between dietary nutrients and aspects of brain health remains unclear. This study examines the neural mechanisms that mediate the relationship between a carotenoid important for brain health across the lifespan, lutein, and crystallized intelligence in cognitively intact older adults. We hypothesized that higher serum levels of lutein are associated with better performance on a task of crystallized intelligence, and that this relationship is mediated by gray matter structure of regions within the temporal cortex. This investigation aims to contribute to a growing line of evidence, which suggests that particular nutrients may slow or prevent aspects of cognitive decline by targeting specific features of brain aging.Methods: We examined 76 cognitively intact adults between the ages of 65 and 75 to investigate the relationship between serum lutein, tests of crystallized intelligence (measured by the Wechsler Abbreviated Scale of Intelligence), and gray matter volume of regions within the temporal cortex. A three-step mediation analysis was implemented using multivariate linear regressions to control for age, sex, education, income, depression status, and body mass index.Results: The mediation analysis revealed that gray matter thickness of one region within the temporal cortex, the right parahippocampal cortex (Brodmann's Area 34), partially mediates the relationship between serum lutein and crystallized intelligence.Conclusion: These results suggest that the parahippocampal cortex acts as a mediator of the relationship between serum lutein and crystallized intelligence in cognitively intact older adults. Prior findings substantiate the individual relationships reported within the mediation, specifically the links between (i) serum lutein and temporal cortex structure, (ii) serum lutein and crystallized intelligence, and (iii) parahippocampal cortex structure and crystallized intelligence. This report demonstrates a novel structural mediation between lutein status and crystallized intelligence, and therefore provides further evidence that specific nutrients may slow or prevent features of cognitive decline by hindering particular aspects of brain aging. Future work should examine the potential mechanisms underlying this mediation, including the antioxidant, anti-inflammatory, and membrane modulating properties of lutein.

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“…Un cerebro saludable también implica una nutrición adecuada. Desde la "neurociencia nutricional cognitiva" se intenta evaluar el impacto de la nutrición sobre el funcionamiento cognitivo y la salud cerebral a lo largo del ciclo vital así como contribuir a diseñar intervenciones que permitan la prevención del deterioro cognitivo (Zamroziewicz & Barbey, 2016). Por último, otro aspecto a tener en cuenta son los efectos nocivos del estrés sobre el funcionamiento cognitivo durante el envejecimiento, por lo que se ha planteado que el desarrollo de la resiliencia como estrategia de afrontamiento puede contribuir también al mantenimiento de la salud cerebral (Redolat & Mesa-Gresa, 2015;Mesa-Gresa, Ramos-Campos & Redolat, 2016).…”

Section: Actividades Mentalmente Estimulantes Para Un Cerebro Más Sanounclassified

Reta a Tu Mente, Desafía a Tu Cerebro: Complejidad Ambiental Y Salud Cerebral

Redolat¹,

Gresa²

2016

Revista INFAD de Psicología

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RESUMENSegún datos de la Organización Mundial de la Salud, se calcula que más de 30 millones de personas sufren Enfermedad de Alzheimer en el mundo. Actualmente existe gran interés en desarrollar estrategias que contribuyan a frenar el deterioro cognitivo que acompaña al envejecimiento y, en mayor medida, a las enfermedades neurodegenerativas. El objetivo del presente trabajo es analizar la evidencia experimental que apoya la idea de que las intervenciones basadas en los factores de novedad y complejidad son más efectivas para conseguir un envejecimiento satisfactorio. En modelos animales se ha demostrado que tanto los ambientes enriquecidos como la realización de ejercicio físico voluntario mejoran el rendimiento en tareas de aprendizaje y memoria, disminuyen la respuesta de ansiedad y pueden contrarrestar los efectos deletéreos del estrés. Los estudios en sujetos humanos muestran que aquellas actividades que suponen mayor desafío y reto para el cerebro (como son el bilingüismo o el aprendizaje de tareas nuevas que impliquen desafío a nivel mental) así como las intervenciones basadas en el ejercicio físico son las que mayores beneficios proporcionan. Se considera que este tipo de intervenciones y un estilo de vida activo pueden contribuir a la reserva cognitiva y promover la neuroplasticidad en sentido positivo. Dado que en sujetos humanos resulta difícil aislar los mecanismos que explican cómo la novedad o complejidad del ambiente pueden favorecer la plasticidad a nivel cerebral, en el presente trabajo se describirán los principales resultados obtenidos en estudios neurocientíficos relacionados con los cambios que la exposición a ambientes enriquecidos induce a nivel neurobiológico y conductual. Son necesarios futuros estudios que utilicen técnicas de neuroimagen y otros biomarcadores que permitan explicar por qué aquellas tareas más desafiantes y novedosas pueden inducir modificaciones adaptativas en el cerebro.Palabras Clave: Ambientes enriquecidos-neuroplasticidad-complejidad-demencia-envejecimiento

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Nutritional Cognitive Neuroscience: Innovations for Healthy Brain Aging

Cited by 59 publications

References 92 publications

Nutrient biomarkers shape individual differences in functional brain connectivity: Evidence from omega‐3 PUFAs

Nutrient biomarkers shape individual differences in functional brain connectivity: Evidence from omega‐3 PUFAs

Parahippocampal Cortex Mediates the Relationship between Lutein and Crystallized Intelligence in Healthy, Older Adults

Reta a Tu Mente, Desafía a Tu Cerebro: Complejidad Ambiental Y Salud Cerebral

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