Nutritional Approaches to Treat Sarcopenia

Cederholm, Tommy; Bauer, Jürgen; Cruz-Jentoft, A.J.

doi:10.1002/9781119597896.ch23

Cited by 2 publications

(2 citation statements)

References 94 publications

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“…Moreover, previous studies also reported that compared with the healthy control group, patients with T2DM mainly presented reduced muscle strength and performance, which was related to muscle density (20). The mechanism leading to the decrease of muscle density in patients with T2DM remains unclear, but may be related to insulin resistance and decreased function and number of mitochondria (21,22). The circulating Cre/CysC, which can be used as a predictor of myosteatosis and muscle mass (23), was first reported in 2013 and has received widespread attention.…”

Section: Discussionmentioning

confidence: 99%

Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus

et al. 2022

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BackgroundThe ratio of creatinine to cystatin C (Cre/CysC), a marker of muscle function and muscle mass, can be used to predict sarcopenia in different populations. Since sarcopenia is closely associated with osteoporosis, this study investigated the association between Cre/CysC and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).MethodThis cross-sectional study included 391 Chinese patients with T2DM. General information, biochemical indicators, and the BMD of lumbar spine (LS), femoral neck (FN), and total hip (TH) were measured.ResultsPearson correlation analysis showed that Cre/CysC was significantly positively correlated with the BMD of LS (r = 0.170, p = 0.001), FN (r = 0.178, p < 0.001), and TH (r = 0.205, p < 0.001). The results of stepwise linear regression suggested that Cre/CysC was the only biochemical predictor of the BMD at three sites (LS: β = 0.137, p = 0.01; FN: β = 0.097, p = 0.038; TH: β = 0.145, p = 0.002).ConclusionIn older patients with T2DM, high Cre/CysC value is independently positively associated with BMD and hence, Cre/CysC may serve as a valuable marker of osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus

et al. 2022

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“…[1,2] Sarcopenia has dramatic consequences such as impaired physical conditions, fragility, increased risk of falls, and osteoporotic fractures. [3,4] It is estimated that the number of people with sarcopenia will increase to 500 million by 2050 [5] and will bring about poor health status and high health care costs. Lack of exercise, poor nutrition, and androgen deficiency may be among the modifiable contributors to sarcopenia.…”

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A Phytomolecule Icariin Protects from Sarcopenia Partially by Suppressing Myosin Heavy Chain Degradation in Orchiectomized Rats

Yang

Cao

et al. 2022

Advanced Biology

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Treatments are lacking for sarcopenia, which is an age‐related disease characterized by loss of skeletal muscle mass, strength, and/or physical performance. Icariin is a phytomolecule from herbal Epimedium, a traditional Chinese medicine widely used to treat musculoskeletal disorders for thousands of years. Here the effects of icariin against sarcopenia are investigated and the underlying mechanism is elucidated. A classic rat model of bilaterally orchiectomized (ORX) is used to induce sarcopenia. After administration for 8 weeks, compared to the control group, the forelimb grip strength, the specific tetanic forces of the soleus (SOL) and extensor digitorum longus muscle (EDL) are higher, and the fiber cross‐sectional areas (CSAs) of the gastrocnemius and tibialis anterior muscle are larger in the icariin group. In addition, icariin promotes mRNA and protein expressions of myosin heavy chain (MyHC) both in SOL and EDL. Mechanistically, icariin significantly suppresses the mRNA and protein expressions of FOXO3a, atrogin‐1, and MuRF‐1, which are related to the degradation of myosin heavy chain. Collectively, icariin protects from sarcopenia in ORX rats characterized by enhancing grip strength and skeletal muscle contraction, as well as increasing skeletal muscle CSA by inhibiting the ubiquitination degradation of the MyHC in skeletal muscle fibers.

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Nutritional Approaches to Treat Sarcopenia

Cited by 2 publications

References 94 publications

Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus

Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus

A Phytomolecule Icariin Protects from Sarcopenia Partially by Suppressing Myosin Heavy Chain Degradation in Orchiectomized Rats

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