Association between the ratio of serum creatinine to cystatin C and bone mineral density in Chinese older adults patients with type 2 diabetes mellitus

Abstract

BackgroundThe ratio of creatinine to cystatin C (Cre/CysC), a marker of muscle function and muscle mass, can be used to predict sarcopenia in different populations. Since sarcopenia is closely associated with osteoporosis, this study investigated the association between Cre/CysC and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).MethodThis cross-sectional study included 391 Chinese patients with T2DM. General information, biochemical indicators, and the BMD of lumbar spine (LS), femoral neck (FN), and total hip (TH) were measured.ResultsPearson correlation analysis showed that Cre/CysC was significantly positively correlated with the BMD of LS (r = 0.170, p = 0.001), FN (r = 0.178, p < 0.001), and TH (r = 0.205, p < 0.001). The results of stepwise linear regression suggested that Cre/CysC was the only biochemical predictor of the BMD at three sites (LS: β = 0.137, p = 0.01; FN: β = 0.097, p = 0.038; TH: β = 0.145, p = 0.002).ConclusionIn older patients with T2DM, high Cre/CysC value is independently positively associated with BMD and hence, Cre/CysC may serve as a valuable marker of osteoporosis.

Association between the ratio of serum creatinine to cystatin C and bone mineral density in middle-aged and older adults: a cross-sectional study from NHANES database

“…The study by Gao et al. 11 suggests that CCR might influence muscle mass and BMD in elderly Chinese people with type 2 diabetes. In another study, the calcaneal bone velocity of sound was used as a substitute for BMD to validate CCR as a simple measure of bone mass that is independent of muscle mass.…”

“…However, since creatinine levels can be influenced by renal function and other factors, muscle mass cannot be solely determined by creatinine. 11 Serum cystatin C is an endogenous marker that accurately reflects glomerular filtration rate and is not influenced by factors such as gender, age, diet, or muscle mass, making it a reliable indicator of kidney function. Therefore, cystatin C is commonly used for early evaluation of renal function damage.…”