Nutritional and therapeutic values of Coccinea grandis: A review

Neetu, .; Purwar, Shalini; Bisht, Vinita; Neeraj, ..; Maurya, Brijesh Kr

doi:10.22271/chemi.2020.v8.i4o.9832

Cited by 2 publications

(2 citation statements)

References 8 publications

(9 reference statements)

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“…It becomes sweet, soft, and juicy once it is ripened. In the traditional system of medicine, fruits of Coccinia grandis have been used to treat leprosy, fever, asthma, bronchitis, and jaundice [ 9 , 10 , 11 , 12 , 13 ]. Recently, it was discovered that the polysaccharide found in Coccinia grandis can be used as an anti-diabetic agent [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Mucilage of Coccinia grandis as an Efficient Natural Polymer-Based Pharmaceutical Excipient

Ilango

Gowthaman

Seramaan³

et al. 2022

Polymers

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Natural eco-friendly materials are recently employed in products to replace synthetic materials due to their superior benefits in preserving the environment. The herb Coccinia grandis is widely distributed in continents like Asia and Africa and used traditionally to treat fever, leprosy, asthma, jaundice, and bronchitis. Mucilage of Coccinia grandis was accordingly extracted, isolated by a maceration technique, and precipitated. The mucilage was evaluated for its physicochemical, binding, and disintegrant properties in tablets using paracetamol as a model drug. The crucial physicochemical properties such as flow properties, solubility, swelling index, loss on drying, viscosity, pH, microbial load, cytotoxicity was evaluated and the compatibility was analyzed using sophisticated instrumental methods (TGA, DTA, DSC, and FTIR). The binding properties of the mucilage was used at three different concentrations and compared with starch and PVP as examples of standard binders. The disintegrant properties of mucilage were used at two different concentrations and compared with standard disintegrants MCCP, SSG, and CCS. The tablets were punched and evaluated for their hardness, friability, assay, disintegration time, in vitro dissolution profiles. In vitro cytotoxicity studies of the mucilage were performed in a human embryonic kidney (HEK) cell line. The outcome of the study indicated that the mucilage had good performance compared with starch and PVP. Further, the mucilage acts as a better disintegrant than MCCP, SSG and CCS for paracetamol tablets. Use of a concentration of 3% or less demonstrated the ability of the mucilage to act as a super disintegrating agent and showed faster disintegration and dissolution, which makes it as an attractive, promising disintegrant in formulating solid dosage forms to improve the therapeutic efficacy and patient compliance. Moreover, the in vitro cytotoxicity evaluation results demonstrated that the mucilage is non-cytotoxic to human cells and is safe.

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Section: Introductionmentioning

confidence: 99%

Mucilage of Coccinia grandis as an Efficient Natural Polymer-Based Pharmaceutical Excipient

Ilango

Gowthaman

Seramaan³

et al. 2022

Polymers

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“…It is commonly found in Asian countries such as India, Pakistan, and Sri Lanka and also distributed in Tropical Africa [8]. In traditional system of medicine, fruits of Coccinia grandis have been used to treat leprosy, fever, asthma, bronchitis, and jaundice [9][10][11][12][13]. Recently, it was discovered that the polysaccharide found in Coccinia grandis can be used as an anti-diabetic agent [14].…”

Section: Introductionmentioning

confidence: 99%

Mucilage of <em>Coccinia grandis</em> as an Efficient Natural Polymer-Based Pharmaceutical Excipient

Ilango¹,

Gowthaman²,

Seramaan³

et al. 2021

Preprint

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Mucilage from Coccinia grandis was extracted, isolated by maceration technique and precipitated, accordingly. The mucilage was evaluated for its physicochemical, binding, and disintegrant properties in tablets using paracetamol as a model drug. The crucial physicochemical properties such as flow properties, solubility, swelling index, loss on drying, viscosity, pH, microbial load, cytotoxicity were evaluated and the compatibility was analysed using sophisticated instrumental methods (TGA, DTA, DSC, and FTIR). The binding properties of the mucilage were used at three different concentrations and compared with starch and PVP as standard binders. The disintegrant properties of mucilage were used at two different concentrations and compared with standard disintegrants MCCP, SSG, and CCS. The wet granulation technique was used for the preparation of granules and was evaluated for the flow properties. The tablets were punched and evaluated for their hardness, friability, assay, disintegration time, in vitro dissolution profiles. In vitro cytotoxicity study of the mucilage was performed in human embryonic kidney (HEK) cell line using cytotoxic assay by MTT method. The outcome of the study indicated that the mucilage had good performance when compared with starch and PVP. Further, the mucilage acts as a good disintegrant than MCCP, SSG and CCS to paracetamol tablets. Moreover, the in vitro cytotoxicity evaluation results demonstrated that the mucilage is non-cytotoxic to human cells and is safe.

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Nutritional and therapeutic values of Coccinea grandis: A review

Cited by 2 publications

References 8 publications

Mucilage of Coccinia grandis as an Efficient Natural Polymer-Based Pharmaceutical Excipient

Mucilage of Coccinia grandis as an Efficient Natural Polymer-Based Pharmaceutical Excipient

Mucilage of <em>Coccinia grandis</em> as an Efficient Natural Polymer-Based Pharmaceutical Excipient

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