Nutrition of the Host and Natural Resistance to Infection

Schneider, Howard A.; Webster, Leslie T.

doi:10.1084/jem.81.4.359

Cited by 36 publications

(7 citation statements)

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“…Thus, on diet 100, the unique class appeared with a greater frequency, 25/30 or 83.3 per cent, among males, than it did among females, 17/30 or 56.7 per cent (X ~ --3.89; P < 0.05). This is in keeping with previous findings (4) in which survivorship among males was slightly greater than amoung females. Consequently, it was decided to use only one sex, and since the dietary effect was greater among the males, this sex was chosen for all subsequent experiments.…”

Section: Separate Population Dynamics Of Virulent and Avirulent Salmosupporting

confidence: 93%

Nutrition of the Host and Natural Resistance to Infection

Schneider

Zinder

1956

The Journal of Experimental Medicine

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In a continuing inquiry into the problems of intra-specitic natural resistance to infection, this laboratory, since 1940, has focused on mouse salmonellosis as an infection model, with nutritional manipulations of the host as the main interest of study. During the course of these investigations it was found that a nutritionally arranged difference in survivorship had its operational base in what was named "the double strain phenomenon" (1). Briefly, this involved the infection of the mice by the combined use of two strains of Salmonella typhimurium, one avirulent and the other virulent. On this information an assay was devised to detect survivorship differences with maximal sensitivity, the so called double strain inoculation test. Using this method of assay a program was begun to identify chemically the nutritional factor or factors promoting increased survivorship.In appfication it has been found that the double strain inoculation test has not been unburdensome in its statistical demands on the number of animals needed and in the amount of nutritional material which had to be prepared during the course of the various chemical fractionations. For practical reasons, therefore, an attempt was made to improve the method of assay. This improved assay, as will be shown, is based on the measurement of the population sizes of the virulent S. typhimurium in the spleens of mouse hosts in the presence of the avirulent form. This was achieved by the use of a distinguishing genetic marker. It is the purpose of the present paper to set forth this improved and more practicable form of the double strain inoculation method of assay. Materials and MethodsAnimals.--The mice used were from a strain of W-Swiss mice, the same as employed in previous investigations (1). The program of outbreeding, previously described (2), has been continued and the stock was free of Sa/mond/a.

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Section: Separate Population Dynamics Of Virulent and Avirulent Salmosupporting

confidence: 93%

Nutrition of the Host and Natural Resistance to Infection

Schneider

Zinder

1956

The Journal of Experimental Medicine

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“…In modern times, one of the first reports describing an interaction between genes and diet can be traced back to 1945. 4 The investigators demonstrated that a diet of whole wheat and whole dried milk was able to promote a higher survival rate among W-Swiss mice subjected to S. enteritidis infection than a ''synthetic'' diet. However, the ability of diet to condition natural resistance was found to depend upon the genetic constitution of the mice employed.…”

Section: Historical Backgroundmentioning

confidence: 99%

Fundamentals of Nutrigenetics and Nutrigenomics

Bouchard¹,

Ordovas²

2012

Progress in Molecular Biology and Translational Science

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“…From this selection it follows that we are concerned with "natural resistance," a phenomenon for which several parameters have been previously identified and others suggested. For example, in mouse salmonellosis, predicted differences in host survivorship can be arranged by either genetic (1,2) or nutritional (3)(4)(5) means. In the present investigation we have elected the genetic arrangement of host differences in survivorship.…”

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confidence: 99%