Nutrition, Lifestyle, and Breast Cancer Risk Among Turkish Women

Çeber, Esin; Soğukpınar, Neriman; Mermer, Gülengül; Aydemir, Gülsün

doi:10.1207/s15327914nc5302_4

Cited by 15 publications

(17 citation statements)

References 23 publications

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“…Diabetes mellitus (OR 1.52, 95% CI 1.30-1.78) [30] and smoking were reported to increase the breast cancer risk [34], but not to a similar extent for all regions [35]. In contrast to reports from developed countries [36,37], a higher body mass index is not associated with premenopausal breast cancer, but is linked to postmenopausal breast cancer in Asian populations [38].…”

Section: Risk Factorsmentioning

confidence: 99%

Current Status and Future Projections of Breast Cancer in Asia

2015

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Asia is the world's largest continent comprising about 3/5 of the human population. Breast cancer is the most common type of cancer and the second leading cause of cancer-related deaths among women in Asia, accounting for 39% of all breast cancers diagnosed worldwide. The incidence of breast cancer in Asia varies widely across the continent and is still lower than in Western countries, but the proportional contribution of Asia to the global breast cancer rates is increasing rapidly in parallel to the socioeconomic development. However, the mortality-to-incidence ratios are much higher for Asia than for Western countries. Most Asian countries are low- and middle-income countries (LMICs) where breast cancer presents at a younger age and a later stage, and where patients are more likely to die from the disease than those in Western countries. Moreover, diagnostic workup, treatment and palliative services are inadequate in most Asian LMICs. In this review, we present an overview of the breast cancer risk factors and epidemiology, control measures, and cancer care among Asian countries.

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Section: Risk Factorsmentioning

confidence: 99%

Current Status and Future Projections of Breast Cancer in Asia

2015

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“…Obesity is also associated with reduced plasma levels of sex hormone – binding globulin, a protein responsible for the biological activity of estrogens [5]. Notably, obesity is also a cause of insulin resistance, which is characterized by hyperinsulinemia [6] that, in patients with breast cancer, has been associated with an higher probability of distant recurrence and increased mortality [7]. The mitogenic, antiapoptotic, and proangiogenic properties of insulin have been suggested as an explanation of its implication in cancer progression; furthermore, insulin is able to stimulate the synthesis of IGF-1, which has multiple effects that have been linked to tumor growth and metastasis [8].…”

Section: Introductionmentioning

confidence: 99%

Body Mass Index and Serum Proteomic Profile in Breast Cancer and Healthy Women: A Prospective Study

et al. 2012

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Epidemiological studies suggest a possible association between BMI, diagnosis and clinical-pathological breast cancer characteristics but biological bases for this relationship still remain to be ascertained. Several biological mechanisms play a role in the genesis and progression of breast cancer. This study aimed to investigate relationships between BMI and breast cancer diagnosis/progression in a Southern Italian population and to try to interpret results according to the serum proteomic profile of healthy and breast cancer patients.BMI, presence or absence of breast cancer and its clinical-pathological characteristics were analyzed in a series of 300 breast cancer women and compared with those of 300 healthy women prospectively. To investigate whether obesity is associated with alterations in serum protein profile, SELDI-ToF approach was applied.Alcohol consumption (22.7% vs 11.3%; p<0.001) and postmenopausal status (65.7% vs 52%; p<0.001) but not BMI resulted significantly different in patients vs controls. Conversely, BMI was significantly associated with a larger-tumour size (BMI> = 30 respect to normal weight: OR = 2.49, 95% CI 1.25–4.99, p = 0.0098) and a higher probability of having positive axillary lymph node (OR = 3.67, CI 95% 2.16–6.23, p<0.0001). Multivariate analysis confirmed the association of breast cancer diagnosis with alcohol consumption (OR = 2.28;CI 1.36–3.83; p<0.0018). Serum protein profile revealed the presence of significant (p-value <0,01) differentially expressed peaks m/z 6934, m/z 5066 in high BMI breast cancer patients vs healthy subjects and m/z 6934, m/z 3346 in high vs low BMI breast cancer patients.The analysis of pathological features of cancer indicates that normal weight women have a significantly higher probability of having a smaller breast cancer at time of diagnosis and negative axillary lymph nodes while increased BMI is associated with an altered protein profile in breast cancer patients. Further studies to identify specific proteins found in the serum and their role in breast cancerogenesis and progression are in progress.

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“…Having a stressor experienced in the last 5 years among the biopsychosocial variables was determined as an independent variable that considerably increased the risk of breast cancer. A study conducted in Turkey by Ceber et al (9) found no difference between the study and control groups in terms of the degree of stressor experienced in the last 5 years. On the other hand, similar to the results of the present study, it was reported that the self-reported stress in the last 5 years (15,22,23), having a stressful vital event in the last 2 years (24), and having stressful life events before the diagnosis (25) were associated with breast cancer.…”

Section: öZkan Et Al Risk Factors In Breast Cancermentioning

confidence: 87%

“…Several studies have researched risk factors for breast cancer in Turkey (9,10). However, factors such as social support and coping style were not assessed in association with stress.…”

mentioning

confidence: 99%

Roles of Biopsychosocial Factors in the Development of Breast Cancer

Özkan¹,

Yıldırım²,

Dişçi³

et al. 2017

Eur J Breast Health

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IntroductionCancer, a chronic and life-threatening disease, is an important cause of morbidity and mortality. The most common type of cancer diagnosed in women is breast cancer (1). Early recognition of high-risk women is important because of the development of surgical, medical, and oncologic alternatives for breast cancer, every passing year (2). Enlightening factors that contribute to breast cancer to prevent the disease, determine risk groups, and improve early diagnosis or treatment strategies are required.Even though the etiology of breast cancer was not clearly presented in the past, many epidemiologic risk factor studies have been conducted (3, 4), and many unchangeable and changeable risk factors (lifestyle and psychosocial factors) for breast cancer have been identified. According to some studies, changeable factors are useful for developing preventive strategies for breast cancer (5). However, researching stressful life events independently of factors such as coping style, behavioral pattern, and social support could be a flawed approach. A limited number of studies have examined the effects of these variables on the etiology of breast cancer (5, 6, 7). Socio-economic characteristics as risk factors for breast cancer are also discussed. An opinion suggested that socioeconomic characteristics could be an independent risk factor for breast cancer. Another aspect affecting life style such as reproduction and nutrition may be associated with risk of breast Eur J Breast Health 2017; 13: 206-12 DOI: 10.5152/ejbh.2017.3519 206 ABSTRACT Objective: The aim of this study was to determine the roles of biopsychosocial risk factors in the development of breast cancer. Materials and methods:This hospital-based case-control study included 491 women with breast cancer (study group) and 512 women who did not have cancer or other serious diseases (control group). Biological, psychological, and social risk factors were compared between the two groups. Data were collected using the semi-structured interview, the Stress Assessment Form, and the Coping Strategy Indicator to assess these factors. Results:When the significantly different biopsychosocial variables between the study and the control groups were evaluated together, independent breast cancer risk factors were found as follows: a stressor experienced in the last 5 years, age 40 years and older, inadequate social support perception, use of avoidance coping strategy, being a housewife, having a family history of cancer, and having a body mass index ≥25. Conclusion:This study showed a relationship between breast cancer risk and manageable variables (obesity, stressor and coping strategy, social support, and employment status), age and family history of cancer, which are biopsychosocial factors. Biopsychosocial aspects are becoming a greater part of many different healthcare systems.

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Nutrition, Lifestyle, and Breast Cancer Risk Among Turkish Women

Cited by 15 publications

References 23 publications

Current Status and Future Projections of Breast Cancer in Asia

Current Status and Future Projections of Breast Cancer in Asia

Body Mass Index and Serum Proteomic Profile in Breast Cancer and Healthy Women: A Prospective Study

Roles of Biopsychosocial Factors in the Development of Breast Cancer

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