Nutrition Intervention Trials in Linxian, China: Multiple Vitamin/Mineral Supplementation, Cancer Incidence, and Disease-Specific Mortality Among Adults With Esophageal Dysplasia

Li, Jun Yao; Taylor, Philip R.; Li, Bing; Dawsey, Sanford M.; Wang, Guoqing; Ershow, Abby G.; Guo, Wenyu; Liu, Shu Fan; Yang, Chung S.; Shen, Qiong; Wang, Wen; Mark, Steven D.; Zou, Xiao; Greenwald, Peter; Wu, Yang; Blot, William J.

doi:10.1093/jnci/85.18.1492

Cited by 384 publications

(174 citation statements)

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“…Both ESCC and GCA occur at extremely high rates in the Linxian population, and ESCC/GCA has been the principal cancer endpoint since we began studying this cohort in 1985. 17,18 In recent studies of serum nutrients, we have found similar associations for these nutrients with ESSC and GCA, which differed from their associations with GNCA. 19,20 Participants and methods…”

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confidence: 63%

Human papillomavirus serology and the risk of esophageal and gastric cancers: Results from a cohort in a high‐risk region in China

Kamangar

Qiao

Schiller

et al. 2006

Intl Journal of Cancer

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Each year, esophageal and gastric cancers cause more than 900,000 deaths worldwide. Human papilloma virus (HPV), especially type 16, has been suggested to have a role in the etiology of esophageal cancer, however, the results of previous seroepidemiological studies have not been consistent. We conducted a large prospective study to examine the association between serum antibodies to HPV 16, HPV 18 and HPV 73 and subsequent development of esophageal squamous cell carcinoma (ESCC), gastric cardia adenocarcinoma (GCA), and gastric noncardia adenocarcinoma (GNCA) in a high-risk population for these cancers in Linxian, China. Case and control subjects for this study were selected from the 29,584 participants of the Linxian General Population Trial. Prediagnostic serum samples from 99 cases of ESCC, 100 cases of GCA, 70 cases of GNCA, and 381 age-and sex-matched controls were selected for this study. The presence of antibodies to HPV virus-like particles was determined by type-specific enzyme-linked immunosorbent assays. Fewer than 15% of ESCC, GCA, or GNCA cases were positive for each HPV type, and no significant associations were found. The adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for HPV 16 seropositivity and ESCC, GCA, and GNCA risk were 1.6 (0.8-3.3), 1.3 (0.6-2.8) and 0.4 (0.1-1.6), respectively. The comparable ORs (95% CIs) for HPV 18 were 1.0 (0.4-2.2), 0.9 (0.4-2.1) and 1.5 (0.6-3.4). For HPV 73, these figures were 1.3 (0.6-2.5), 1.2 (0.6-2.3) and 0.9 (0.4-2.1). The results of this study do not support a major role for HPV 16, HPV 18 and HPV 73 in the etiology of esophageal and gastric cancers in Linxian, China. ' 2006 Wiley-Liss, Inc.Key words: esophageal cancer; human papillomavirus; serology Oncogenic types of human papillomavirus (HPV), most notably HPV 16 and HPV 18, are recognized as the most significant risk factors for cervical cancer. 1 The role of HPV in the etiology of cancers of vulva, anus, penis and oropharyngeal cavity has also been established. 2 The role of HPV in the etiology of esophageal cancer, however, remains controversial. Syrjanen first suggested a role for HPV in the etiology of esophageal squamous cell carcinoma (ESCC) in 1982, based on observing characteristic histological findings suggesting the presence of HPV in benign esophageal epithelia and malignant esophageal tumors. 3 During the past 20 years, several studies have used a variety of techniques, including detection of HPV DNA in esophageal tumor tissues and serologic methods, to examine the association between exposure to HPV and risk of ESCC. 4 The results of HPV DNA studies have not been consistent: case series using polymerase chain reaction (PCR) have found evidence for the presence of HPV in the tumor tissues varying from 0 to 67%. 4 Type-restricted serologic assays for different HPV types using virus-like particles were first developed in the mid-1990s, 5 and were subsequently shown to be relatively specific for each HPV type. 6 Seroreactivity to HPV 16 is a strong marker of continuous past exp...

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confidence: 63%

Human papillomavirus serology and the risk of esophageal and gastric cancers: Results from a cohort in a high‐risk region in China

Kamangar

Qiao

Schiller

et al. 2006

Intl Journal of Cancer

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“…Compared to the down-regulation rates of MRP14 between the two different regions, no significant difference was found. Dietary factors, nitrosamine exposure and history of injury to the esophagus have been reported to somehow associated with the high incidence of this malignancy in North China [19,20]. However, consistent high down-regulation rates of MRP14 in the two different areas indicated that abnormality of MRP14 gene might not be a downstream event contrib-uted by the environmental and chemical risk factors found in the high-incidence area.…”

Section: Discussionmentioning

confidence: 99%

Expression of MRP14 gene is frequently down-regulated in Chinese human esophageal cancer

Wang

Cai

et al. 2004

Cell Res

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Migration inhibitory factor-related protein 14 (MRP14) is one of calcium-binding proteins, referred as S100A9. The heterodimeric molecule formed by MRP14 with its partner MRP8 (S100A8) is the major fatty acid carrier in neutrophils. The MRP8/14 complex has been also implicated in the intracellular transport of arachidonic acid and its precursors in keratinocytes. We show here the involvement of MRP14 in human esophageal cancer. In an initial study, mRNA differential display -reverse transcription polymerase chain reaction (DD-PCR) was performed with two esophageal carcinomas, one esophageal adenocarcinoma and matched normal adjacent mucosa. DD-PCR with the arbitrary primer OPA3 showed that one cDNA band was highly expressed in normal tissues, but disappeared or substantially decreased in tumor counterparts. It was later identified to be the 3'-end of migration inhibitory factor-related protein 14 (MRP14). Northern blotting, RT-PCR and Western blotting corroborated the down-regulation of MRP14 in 58/64 squamous cell carcinomas and 2/2 adenocarcinomas as compared with adjacent normal epithelia of the esophagus. MRP14 was undetectable in 3/3 esophageal-carcinoma cell lines. Immunochemistry demonstrated that expression of MRP14 was restricted to normal esophageal epithelia. No mutation was found in the genomic DNA of the MRP14 gene by PCR and directed DNA sequencing. Our finding suggested that the reduction of MRP14 expression is a frequent event in Chinese human esophageal cancer.

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“…Unfortunately, conflicting results were obtained in clinical trials conducted in China to test the efficacy of retinoids as chemopreventive agents for oesophageal cancer. In one trial (42), a synthetic retinoid decreased the incidence of oesophageal cancer by 43% (relative to a placebotreated group), whereas inconclusive results were obtained in two other trials (43,44). Recent studies suggest that some retinoids are able to inhibit the growth of oesophageal squamous carcinoma cells in culture by inducing apoptosis and that induction of the apoptotic pathway is dependent on expression (and sometimes induction) of RARβ receptors (39).…”

Section: Retinoid Receptorsmentioning

confidence: 99%

Oesophageal Cancer in Africa

Hendricks

Parker

2002

IUBMB Life

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SummaryOesophageal cancer, the eighth most frequent cancer in the world occurs as two main subtypes, squamous cell carcinoma (more prevalent in developing countries) and adenocarcinoma (more common in developed countries). Certain populations of central, eastern, and southern Africa display very high frequencies of oesophageal squamous cell carcinoma, presenting a serious health burden to the continent. Most patients are diagnosed at a late stage because of the asymptomatic development of the disease, with associated poor prognosis. A better understanding of the aetiological agents and molecular mechanisms involved in the development of oesophageal squamous cell carcinoma may offer opportunities to reduce exposure to environmental risk factors and also allow early diagnosis or predict response to therapy. Epidemiologic studies have identified smoking, alcohol consumption, diets poor in fresh fruit and vegetables, consumption of foods contaminated with Fusarium verticillioides, and HPV infection as risk factors associated with the development of this disease in Africa. Although we have an incomplete understanding of the molecular events involved in the development of oesophageal squamous cell carcinoma, advances have been made that suggest lines of future exploration. South African patients with oesophageal squamous cell carcinoma display a lower incidence of point mutations in the p53 gene than described elsewhere, suggesting that the profile of aetiological agents may be different than described for other high-risk areas for oesophageal cancer. Recent studies suggest that RARβ and COX II is frequently downregulated and upregulated, respectively, in oesophageal squamous cell carcinomas. These results suggest potential therapeutic opportunities that can be exploited to combat the high incidence of this disease in Africa.

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Nutrition Intervention Trials in Linxian, China: Multiple Vitamin/Mineral Supplementation, Cancer Incidence, and Disease-Specific Mortality Among Adults With Esophageal Dysplasia

Cited by 384 publications

References 15 publications

Human papillomavirus serology and the risk of esophageal and gastric cancers: Results from a cohort in a high‐risk region in China

Human papillomavirus serology and the risk of esophageal and gastric cancers: Results from a cohort in a high‐risk region in China

Expression of MRP14 gene is frequently down-regulated in Chinese human esophageal cancer

Oesophageal Cancer in Africa

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