Nutrition and the head and neck cancer patient

Wood, Robert M.; Lander, Vickie L.; Mosby, Edward L.; Hiatt, William R.

doi:10.1016/0030-4220(89)90134-5

Cited by 23 publications

(9 citation statements)

References 13 publications

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“…Malnutrition has negative effects on the progression of disease in general and consequently on mortality. Malnutrition interferes with the immune hormonal and cellular bringing the impairment of liver function, which changes the metabolism of drugs [16][17][18][19][20][21][22]. Because patients in the present study were recruited at the time of diagnosis, and BMI was assessed shortly thereafter, men with a low BMI, i.e., low body weight, may already be suffering from malnutrition that may have caused a weight loss and subsequently a lower BMI.…”

Section: Discussionmentioning

confidence: 99%

Body mass index and mortality in men with prostate cancer

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Body mass index and mortality in men with prostate cancer

et al. 2015

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“…Because the true prevalence of weight loss in head and neck cancer is largely unknown, we sought to perform a systematic review and meta‐analysis of the literature to assess the prevalence of weight loss in this patient population, using the “significant weight loss” definition. As Figure demonstrates, at the time of diagnosis, 20.2 ± 2.9% of patients with head and neck cancer have a significant weight loss, and this number increases to 32.2 ± 4.9% when evaluated before initiation of cancer treatment, which is an average of 21 days later . The meta‐analyses results included in Figure show an increase in the percentage of patients with head and neck cancer with significant weight loss between the time of diagnosis and treatment, reiterating earlier findings showing a similar trend when measuring weight loss at these 2 time points among a similar cohort of patients …”

Section: Methodsmentioning

confidence: 99%

Cancer cachexia update in head and neck cancer: Definitions and diagnostic features

et al. 2014

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Cachexia is a profoundly debilitating wasting syndrome that affects patients with head and neck cancer and often contributes to their demise. A comprehensive literature search was performed up to April 2013 using PubMed, the Cochrane Library, CINAHL, and the Google search engine. For the meta-analyses, pooled prevalence estimates were calculated with a confidence interval of 95% (95% CI) by using random effects modeling. In this review, we outlined the unique challenges of cancer cachexia among patients with head and neck cancer by reviewing its impacts on quality of life (QOL), morbidity, and mortality. We explored the prevalence of different clinical markers of cachexia at the time of diagnosis and before and after treatment. Finally, we present updates regarding the diagnosis of cancer cachexia and recent findings, such as cardiac dysfunction that warrant clinical attention to more carefully identify patients at risk and potentially lead to better outcomes.

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“…Several studies have shown that up to 60% of head and neck cancer patients were nutritionally compromised at initial diagnosis (Donaldson and Lenon, 1979;Bassett and Dobie, 1983;Wood et al, 1989;Bäckström et al, 1995;Lees, 1999;Van Bokhorst-van der Schueren et al, 2001). A pre-operative weight loss of 10% of body weight has been reported as a predictive risk factor for major post-operative complications (Van Bokhorst-van der Schueren et al, 1997).…”

Section: Nutritional Statusmentioning

confidence: 99%

Oral Sequelae of Head and Neck Radiotherapy

Vissink

Jansma

Spijkervet

et al. 2003

Critical Reviews in Oral Biology & Medicine

758

512

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In addition to anti-tumor effects, ionizing radiation causes damage in normal tissues located in the radiation portals. Oral complications of radiotherapy in the head and neck region are the result of the deleterious effects of radiation on, e.g., salivary glands, oral mucosa, bone, dentition, masticatory musculature, and temporomandibular joints. The clinical consequences of radiotherapy include mucositis, hyposalivation, taste loss, osteoradionecrosis, radiation caries, and trismus. Mucositis and taste loss are reversible consequences that usually subside early post-irradiation, while hyposalivation is normally irreversible. Furthermore, the risk of developing radiation caries and osteoradionecrosis is a life-long threat. All these consequences form a heavy burden for the patients and have a tremendous impact on their quality of life during and after radiotherapy. In this review, the radiation-induced changes in healthy oral tissues and the resulting clinical consequences are discussed.

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Nutrition and the head and neck cancer patient

Cited by 23 publications

References 13 publications

Body mass index and mortality in men with prostate cancer

Body mass index and mortality in men with prostate cancer

Cancer cachexia update in head and neck cancer: Definitions and diagnostic features

Oral Sequelae of Head and Neck Radiotherapy

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