Nutrition and Liver Disease

Mandato, Claudia; Nuzzi, Antonella Di; Vajro, Pietro

doi:10.3390/nu10010009

Cited by 34 publications

(22 citation statements)

References 36 publications

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“…Nutrition represents a key factor in the prevention and treatment of both sarcopenia and obesity. Sarcopenia is associated with an inadequate nutritional intake, and nutritional interventions are essential to improve sarcopenia and the subsequent morbidity and mortality in chronic liver diseases (58,59). In contrast, obesity is a result of an excess consumption of energy, resulting in an imbalance between the energy intake and energy expenditure.…”

Section: Discussionmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease Is Associated With Low Skeletal Muscle Mass in Overweight/Obese Youths

et al. 2020

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Background: Recent studies in adult non-elderly and elderly individuals have reported a link between nonalcoholic fatty liver disease (NAFLD) and sarcopenia. Nonetheless, whether this relationship would be found outside these populations it is still unknown. Hence, we evaluated the relationship between NAFLD and skeletal muscle mass in children and adolescents with overweight/obesity. Methods: Two-hundred and thirty-four overweight/obese youths were enrolled. NAFLD was diagnosed by ultrasononography, after exclusion of infectious and metabolic disorders. Forty of the patients with NAFLD had also liver biopsy. Total and regional lean body mass and total fat mass measurements were obtained by dual-energy X-ray absorptiometry. The relative muscle mass (RMM) was defined as the percent of muscle mass (kg) relative to the sum of muscle and fat (kg) mass. Appendicular skeletal muscle mass (ASM) was calculated by the sum of muscle masses of the four limbs (kg), and expressed as percent of body weight. Results: Subjects were stratified according to tertiles of RMM. The prevalence of abdominal obesity, dyslipidemia, insulin resistance, metabolic syndrome, NAFLD as well as biopsy-proven nonalcoholic steatohepatitis (NASH) was significantly increased in the lowest tertile of RMM. After controlling for age, sex and Tanner stage, children in the lowest tertile of RMM had an increased risk for NAFLD (OR= 2.80, 95% CI=1.57-5.02) compared to those in the other two tertiles. This association persisted after additional adjustments for clinical and metabolic variables. Similarly, the risk of NAFLD in the lowest tertile of ASM/weight index was significantly higher compared to those in the other two tertiles after adjustment for the above confounders. Conclusions: This is the first study to establish an independent association between low muscle mass and NAFLD/NASH in overweight/obese youths. Considering the worldwide increase of pediatric obesity, measurements of muscle mass may serve as useful method of identifying among obese children those at high metabolic risk who may need intensive lifestyle interventions to prevent NAFLD and its progression.

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Section: Discussionmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease Is Associated With Low Skeletal Muscle Mass in Overweight/Obese Youths

et al. 2020

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“…[6] Исследование нутритивного статуса у больных хроническими диффузными заболеваниями печени, естественно, является фокусным предметом исследований как диетологов, так и научных исследователей всего мира. [23]. Однако, несмотря на кажущуюся простоту данного вопроса, существует некоторое непонимание как самого вопроса, так и возможности оценки и, соответственно, путей коррекции возникших нарушений.…”

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Nutritional Status as One of the Components of the Metabolic Nutritive State in Patients With Chronic Liver Diseases

Lupașco¹,

Dumbrava²,

Vengher³

et al. 2020

MedFarm

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АННОТАЦИЯ В последнее время наблюдается постепенно, но неуклонно нарастающий интерес медицинской научной общественности к нутритивному состоянию населения. Ученые различных специальностей разрабатывают модели оценки метаболического состояния организма больного на базе основных звеньев, составляющих нутритивный баланс. Питание является одним из немаловажных факторов, составляющих картину нутритивного статуса. В настоящее время существует множество инструментов для оценки состояния питания больного, в том числе и с хронической патологией печени. Знание данного предмета позволит правильно использовать определенный инструмент в каждом отдельном случае, в том числе и в клинической практике у больных с хроническими заболеваниями печени. ABSTRACT Recently, there has been a gradually but steadily growing interest of medical scientific community in the nutritional state of the population. Scientists of various specialties develop models for assessing the metabolic state of the patient's body based on the main links that make up the nutritive balance. Nutrition is one of the important factors that make up the picture of metabolic nutritive status. Currently, there are many tools for assessing the nutritional stare of a patient, including those with chronic liver disease. Knowledge of this subject will allow the correct use of a certain tool in each individual case, including in clinical practice. Ключевые слова: Нутритивный статус, нутрициональное состояние, хронические заболевания печени, пищевая ценность продуктов питания.

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“…Chronic liver disease is a very common clinical disease. Stages of liver disease include hepatitis or steatosis and hepatic stasis, brosis, cirrhosis, and cellular hepatocellular carcinoma (HCC) (1)(2)(3)(4). The goal of treatment is to stop the progression of the disease and its complications and the need for a multidisciplinary approach.…”

mentioning

confidence: 99%

“…The effect that chronic liver disease has on the nutritional status and health of the child is determined by the cause and severity of liver disease and the age of onset. There is a two-way interaction between CLD and malnutrition: CLD often leads to malnutrition, and malnutrition negatively affects the course of liver disease (2)(3)(4)(5). Gradual loss of liver function and cirrhosis in children with CLD cause hemodynamic and metabolic disorders and severe complications such as liver and lung syndrome and renal failure.…”

mentioning

confidence: 99%

“…However, even children with less liver disease need nutritional evaluation and intervention to prevent osteoporosis and the effects of micronutrient de ciency (2). Current recommendations based on our understanding of the effect of CLD on nutritional status, digestion and absorption of nutrients, metabolism, and clinical trials are limited (1)(2)(3)(4)(5). The prognostic and therapeutic role of nutritional issues in the management of patients with liver disease has long been known, and therefore, nutritional status was one of the main prognostic score variables designed by Child and Turcotte (2).…”

mentioning

confidence: 99%

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The effect of specific nutritional modification program on specific liver findings in children with chronic liver disease: A clinical trial

Jafari

Rezaeian

Nomjuo

et al. 2020

Preprint

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Background: Liver disease leads to complex pathophysiological injuries that affect digestion, absorption, distribution, storage and use of food. The effect that chronic liver disease has on the nutritional status and health of the child is determined by the cause and severity of liver disease and the age of onset of liver disease. As liver disease progresses, so do the symptoms and complications of the disease. The aim of this study was to determine the effect of specific nutrition adjustment program on specific liver findings in children with chronic liver disease.Methods: In this clinical trial study, 75 children with chronic liver disease were randomly divided into two groups (45 in the intervention group and 30 in the control group). At the beginning of the study, the necessary experiments were taken from two groups. The intervention group received a nutritional adjustment program during 6 sessions of the workshop. After 12 weeks of follow-up, bilirubin level (total, direct), albumin level, PT, INR, transaminases (AST, ALT) were measured in both groups. Data analysis was performed using SPSS software version 16 and Wilcoxon and Mann-Whitney tests.Results: At the beginning of the study, both groups were homogeneous in terms of demographic variables. In the post-intervention stage compared to the pre-intervention stage in the intervention group, the mean scores of prothrombin time (P = 0/040), albumin (P = 0/007), aspartate transaminase and alanine transaminase (p˂0/001)were statistically significant:. But the mean score of total bilirubin (P = 0/063) in the post-intervention stage compared to before the intervention in the intervention group was not statistically significant.Conclusion: Nutrition education and encouragement of patients with chronic liver disease to follow a special diet can be an important factor in feeling healthy and preventing the progression of the disease.Trial registration: Name of registry: Zahra NamjouIRCT registration number: IRCT2015091424019N1 Registration date: 2016-01-30 Registration timing: retrospective

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Nutrition and Liver Disease

Cited by 34 publications

References 36 publications

Nonalcoholic Fatty Liver Disease Is Associated With Low Skeletal Muscle Mass in Overweight/Obese Youths

Nonalcoholic Fatty Liver Disease Is Associated With Low Skeletal Muscle Mass in Overweight/Obese Youths

Nutritional Status as One of the Components of the Metabolic Nutritive State in Patients With Chronic Liver Diseases

The effect of specific nutritional modification program on specific liver findings in children with chronic liver disease: A clinical trial

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