Nutrition and cervical neoplasia

Potischman, Nancy; Brinton, Louise A.

doi:10.1007/bf00115643

Cited by 91 publications

(61 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Low intake of ascorbic acid and other vitamins was associated with an increased risk of cervical cancer in two of three studies reported [88][89][90][91]. This relationship needs further study because the results suggest that other nutrients including vitamin E, carotenoids, retinoic acid either individually or in synergy with ascorbic acid may impart a protective effect against various cancers.…”

Section: Ascorbic Acid and Cancermentioning

confidence: 95%

A Review of the Nature and Effectiveness of Nutrition Interventions in Adult Males: A Guide for Intervention Strategies

Coles¹

2013

Functional Foods

View full text Add to dashboard Cite

Ascorbic acid is one of the important water soluble vitamins. It is essential for collagen, carnitine and neurotransmitters biosynthesis. Most plants and animals synthesize ascorbic acid for their own requirement. However, apes and humans can not synthesize ascorbic acid due to lack of an enzyme gulonolactone oxidase. Hence, ascorbic acid has to be supplemented mainly through fruits, vegetables and tablets. The current US recommended daily allowance (RDA) for ascorbic acid ranges between 100-120 mg/per day for adults. Many health benefits have been attributed to ascorbic acid such as antioxidant, anti-atherogenic, anti-carcinogenic, immunomodulator and prevents cold etc. However, lately the health benefits of ascorbic acid has been the subject of debate and controversies viz., Danger of mega doses of ascorbic acid? Does ascorbic acid act as a antioxidant or pro-oxidant ? Does ascorbic acid cause cancer or may interfere with cancer therapy? However, the Panel on dietary antioxidants and related compounds stated that the in vivo data do not clearly show a relationship between excess ascorbic acid intake and kidney stone formation, pro-oxidant effects, excess iron absorption. A number of clinical and epidemiological studies on anti-carcinogenic effects of ascorbic acid in humans did not show any conclusive beneficial effects on various types of cancer except gastric cancer. Recently, a few derivatives of ascorbic acid were tested on cancer cells, among them ascorbic acid esters showed promising anticancer activity compared to ascorbic acid. Ascorbyl stearate was found to inhibit proliferation of human cancer cells by interfering with cell cycle progression, induced apoptosis by modulation of signal transduction pathways. However, more mechanistic and human in vivo studies are needed to understand and elucidate the molecular mechanism underlying the anti-carcinogenic property of ascorbic acid. Thus, though ascorbic acid was discovered in 17 th century, the exact role of this vitamin/nutraceutical in human biology and health is still a mystery in view of many beneficial claims and controversies. Historical perspectiveThe sea voyager/sailors developed a peculiar disease called scurvy when they were on sea. This was found to be due to eating non-perishable items and lack of fresh fruits and vegetables in their diet. A British naval Physician, Lind [1] documented that there was some substance in citrus fruits that can cure scurvy. He developed a method to concentrate and preserve citrus juice for use by sailors. British Navy was given a daily ration of lime or lemon juice to overcome ascorbic acid deficiency. Ascorbic acid was first isolated from natural sources and structurally character-

show abstract

Section: Ascorbic Acid and Cancermentioning

confidence: 95%

A Review of the Nature and Effectiveness of Nutrition Interventions in Adult Males: A Guide for Intervention Strategies

Coles¹

2013

Functional Foods

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies have linked ? low folate status or low levels of intake with increased risk for colorectal, lung, and cervical cancer (58,66,77), as well as cardiovascular diseases (9,40,47), and abnormalities of DNA methylation in colonic neoplasms are frequently observed (46). In the assessment of the relationship between folate intake, cancer risk, and MTHFR polymorphisms, dietary factors that may influence folate requirements, such as methyl donors and alcohol (which adversely affects folate metabolism), also need to be examined.…”

Section: Polymorphisms Of Methylenetetrahydrofolate Reductase and Folatementioning

confidence: 99%

Nutrition, Genetics, and Risks of Cancer

Rock

Lampe

Patterson

2000

Annu. Rev. Public Health

View full text Add to dashboard Cite

diets Abstract Dietary patterns, nutrients, and other constituents of food are major components of the environmental influences that contribute to risk for cancer, and the study of interactions between nutritional and genetic factors is a new and important area of research. This review describes the concepts and principles underlying this area of study and types of relationships between nutritional and genetic factors, and it provides examples of specific diet-gene interactions that are of current interest, with an emphasis on implications for cancer prevention and public health. Polymorphisms exist in the genes for the activating and conjugating metabolizing enzymes, and the induction of metabolizing enzyme activity by nutritional factors may result in either the activation of a carcinogen or the detoxification of a reactive intermediate metabolite. The relationship between the methylenetetrahydrofolate reductase gene and dietary folate is an example of a diet-gene interaction that involves a polymorphism in a vitamin metabolism gene, and the presence of the variant appears to influence both risk for cancer and folate requirements. Diet-gene interactions likely contribute considerably to the observed inter-individual variations in cancer risk in response to exposures to the nutritional factors that have the potential to promote or protect against cancer. Insights into mechanisms by which nutritional factors affect the process of carcinogenesis are provided by knowledge of the targeted gene function and enzyme activity. Increased knowledge in this area will allow a more refined approach to reducing risk for cancer, with diet interventions targeted toward individuals and subgroups that are genetically susceptible and responsive to the effects of nutritional factors.Investigating the cellular and molecular pathogenesis of cancer is an established and important area of basic science research. Within the past several years, the capability of examining biomarkers of various genetic factors in the development and progression of chronic diseases, such as cancers, has enabled researchers to study these factors in clinical and community-based populations, in which environmental factors can also be measured or even manipulated.

show abstract

“…For example, in case-control and cohort studies, inverse associations between serum carotenoids and α-tocopherol, potent antioxidant nutrients, and risk for CIN and cancer have been observed. 20 Similarly, inflammation and cigarette smoking, contributors to high oxidant load, have been positively associated with CIN and cancer risk in case-control analyses. [19][20] Recently smoking has been shown to decrease the probability of clearing an oncogenic infection.…”

Section: Hpv and Cervical Carcinogenesismentioning

confidence: 99%

“…20 Similarly, inflammation and cigarette smoking, contributors to high oxidant load, have been positively associated with CIN and cancer risk in case-control analyses. [19][20] Recently smoking has been shown to decrease the probability of clearing an oncogenic infection. 21 Infection with other sexually acquired infections may act independently of HPV to promote cervical carcinogenesis or may act by inducing an inflammatory response, alter the redox potential of the cell and thereby increase HPV carcinogenesis.…”

Section: Hpv and Cervical Carcinogenesismentioning

confidence: 99%

See 1 more Smart Citation

Cervical carcinogenesis: the role of co-factors and generation of reactive oxygen species

Giuliano

2003

Salud pública Méx

View full text Add to dashboard Cite

ResumenDiversos co-factores de riesgo han sido asociados consistentemente con displasia cervical y cáncer invasor. Es necesario un mayor número de investigaciones que utilicen diseños de cohorte prospectivos para describir el proceso de carcinogénesis y el mecanismo biológico de cada uno de estos factores. Adicionalmente, futuras investigaciones serán necesarias para definir el papel de los anticonceptivos hormonales en la promoción de la carcinogénesis cervical. Mientras que muchas preguntas científicas interesantes permanecen sin ser respondidas, resultados de numerosos estudios epidemiológicos que se desarrollan actualmente, indican que la displasia cervical y cáncer podrán ser reducidos si la tasa de oxidantes-antioxidantes es cambiada a más de un perfil antioxidante. Además de la detección oportuna de cáncer cervical, puede lograrse una reducción de la incidencia de esta enfermedad disminuyendo el consumo de tabaco, incrementando el estatus nutricional, y utilizando métodos contraceptivos de barrera para prevenir otras infecciones de transmisión sexual. Este artículo también está disponible en: http://www.insp.mx/salud/index.html Palabras clave: cáncer cervical; co-factores de riesgo; antioxidantes; nutrición; prevención This paper is available too at: http://www.insp.mx/salud/index.html Abstract Several HPV co-factors have been proposed, some more or less consistently associated with cervical dysplasia and cancer risk. More research, using prospective cohort designs, is needed to further describe where in carcinogenesis these factors are working and to assess the biological mechanism of these factors. In addition, further research is needed to define the role of various hormonal contraceptive formulations in promoting cervical carcinogenesis. While many interesting scientific questions remain to be answered, results from the numerous epidemiological studies conducted to date indicate that cervical dysplasia and cancer may be reduced if the oxidant antioxidant ratio is shifted to more of and antioxidant profile. In addition to cervical cancer screening, a reduction in cervical cancer incidence may be accomplished by reducing tobacco use, increasing nutritional status, and utilizing barrier contraception to prevent infection with other sexually acquired infections. This paper is available too at: http:// www.insp.mx/salud/index.html

show abstract

Nutrition and cervical neoplasia

Cited by 91 publications

References 60 publications

A Review of the Nature and Effectiveness of Nutrition Interventions in Adult Males: A Guide for Intervention Strategies

A Review of the Nature and Effectiveness of Nutrition Interventions in Adult Males: A Guide for Intervention Strategies

Nutrition, Genetics, and Risks of Cancer

Cervical carcinogenesis: the role of co-factors and generation of reactive oxygen species

Contact Info

Product

Resources

About