Nutrition and bile formation

Tuchweber, Béatriz; Yousef, Ibrahim M.; Ferland, Guylaine; Perea, A.

doi:10.1016/0271-5317(96)00104-2

Cited by 27 publications

(11 citation statements)

References 157 publications

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“…Futhermore, it is known that hepatic cholesterol is depleted during smoltification (Boeuf 1993). In mammals, diets containing high levels of cholesterol stimulate biliary secretion of bile acids to maintain cholesterol homoeostasis (Tuchweber et al 1996). Conversely, in fish, it is unclear whether de novo cholesterol synthesis can compensate for decreased dietary cholesterol in bile acid formation.…”

Section: Discussionmentioning

confidence: 99%

Digestibility ofCalanus finmarchicuswax esters in Atlantic salmon (Salmo salar) freshwater presmolts and seawater postsmolts maintained at constant water temperature

Oxley

Bogevik

Henderson

et al. 2009

Aquaculture Nutrition

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Calanoid copepods are a rich source of marine lipid for potential use in aquafeeds. Copepod oil is primarily composed of wax esters (WE) and there are concerns over the efficiency of wax ester, versus triacylglycerol (TAG), digestion and utilization in fish. As smoltification represents a period of major physiological adaptation, the present study examined the digestibility of a high WE diet (Calanus oil; 48% WE, 26% TAG), compared with a TAG diet (fish oil; 58% TAG), in Atlantic salmon freshwater presmolts and seawater postsmolts, of similar age (9 months) and weight (112 g and 141 g initial, respectively), over a 98‐day period at constant temperature. Fish grew significantly better, and possessed lower feed conversion ratios (FCR), in seawater than freshwater. However, total lipid apparent digestibility coefficient (ADC) values were significantly lower in seawater fish, as were total fasted bile volumes. Dietary Calanus oil also had a significant effect, reducing growth and lipid ADC values in both freshwater and seawater groups. Postsmolts fed dietary Calanus oil had the poorest lipid ADC values and analysis of faecal lipid class composition revealed that 33% of the remaining lipid was WE and 32% fatty alcohols. Dietary prevalent 22:1n‐11 and 20:1n‐9 fatty alcohols were particularly poorly utilized. A decrease in primary bile acid, taurocholate, concentration was observed in the bile of dietary Calanus oil groups which could be related to the lower cholesterol content of the diet. The dietary WE : TAG ratio is discussed in relation to life stage and biliary intestinal adaptation to the seawater environment postsmoltification.

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Section: Discussionmentioning

confidence: 99%

Digestibility ofCalanus finmarchicuswax esters in Atlantic salmon (Salmo salar) freshwater presmolts and seawater postsmolts maintained at constant water temperature

Oxley

Bogevik

Henderson

et al. 2009

Aquaculture Nutrition

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“…This could have related to the quality or type of dietary fatty acids that reach the liver when different types of dietary fibre are present. Hepatic production of bile acids is incompletely understood, but partly depends upon both the availability and the type of fatty acid, such as n-3 fatty acid, presented to the liver [19]. The increased flux of certain long-chain fatty acids to the liver in FABP2 T54 subjects might have chronically depressed the hepatic production of bile acids.…”

Section: Discussionmentioning

confidence: 99%

Intestinal fatty acid‐binding protein variation associated with variation in the response of plasma lipoproteins to dietary fibre

Hegele

Wolever

Story

et al. 1997

Eur J Clin Investigation

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Increased dietary fibre intake is a component of prudent dietary advice, although the mechanism of its beneficial effect is unclear. Furthermore, plasma lipoprotein response to dietary fibre seems to vary both between individuals and according to the type of fibre consumed. Two common genetic variants, A54 and T54, of the intestinal fatty acid-binding protein gene (FABP2) have different in vitro binding affinities for long-chain fatty acids. We have hypothesized that variation in FABP2 would be associated with interindividual variation in the response of plasma lipoproteins to either dietary soluble or insoluble fibre. We studied 43 subjects who participated in a year-long cross-over study of the effect of insoluble and soluble fibre on plasma lipoproteins. We tested for associations between FABP2 genotypes and the response of plasma lipoproteins to dietary fibre. When compared with subjects homozygous for FABP2 A54, we found that subjects with FABP2 T54 had significantly greater decreases in plasma total and low-density lipoprotein (LDL)-cholesterol and apoB during the period when the diet was high in soluble fibre than during the period when the diet was high in insoluble fibre. Furthermore, compared with subjects with the FABP2 A54 allele, subjects with the FABP2 T54 allele had significantly lower secretion of total fecal bile acids, but this did not increase with dietary soluble fibre. Genetic variation in FABP2 may thus contribute to interindividual variation in the response of plasma lipoproteins to different dietary fibres, but the mechanism does not appear to be related to increases in fecal bile acid secretion.

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“…3‐hydroxy 3‐methyl glutaryl coenzyme A (HMG CoA) reductase inhibitors (also called “statins”) inhibit cholesterol synthesis at the rate limiting step (Tuchweber et al . 1996), which in turn results in the upregulation of LDL receptor number (Chapman et al .…”

Section: Introductionmentioning

confidence: 99%

Lipid-Lowering Efficacy of Piperine From Piper Nigrum L. In High-Fat Diet and Antithyroid Drug-Induced Hypercholesterolemic Rats

Vijayakumar

Nalini

2006

J Food Biochemistry

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Male Wistar rats were divided into two groups: control diet group and high‐fat diet group (HFD). Both groups were divided into four subgroups, each consisted of 10 animals, and the diets were supplemented with the following ingredients for 10 weeks: (1) 1% carboxymethyl cellulose; (2) 10 mg carbimazole (CM)/kg body weight; (3) 10 mg CM + 40 mg piperine/kg body weight; and (4) 10 mg CM + 2 mg atorvastatin/kg body weight. Feeding HFD to rats significantly (P < 0.05) elevated plasma total cholesterol, triglycerides, phospholipids, free fatty acids, low‐density lipoprotein (LDL), very low‐density lipoprotein (VLDL) and the activity of 3‐hydroxy 3‐methyl glutaryl coenzyme A (HMG CoA) reductase in the liver, heart and aorta, while the activities of plasma and tissue lipoprotein lipase (LPL) and plasma lecithin cholesterol acyl transferase (LCAT) and high‐density lipoprotein were significantly (P < 0.05) lowered compared to control rats. Supplementing piperine with HFD significantly (P < 0.05) reduced the levels of plasma total cholesterol, LDL, VLDL tissue HMG CoA reductase and significantly (P < 0.05) elevated the levels of LPL and LCAT compared to rats that did not receive piperine. Fecal bile acids and neutral sterols were also elevated in HFD‐fed rats as compared to control animals, while simultaneous supplementation of piperine significantly (P < 0.05) enhanced further excretion of bile acids and neutral sterols. The results indicate that piperine can prevent the accumulation of plasma lipids and lipoproteins significantly by modulating the enzymes of lipid metabolism.

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Nutrition and bile formation

Cited by 27 publications

References 157 publications

Digestibility ofCalanus finmarchicuswax esters in Atlantic salmon (Salmo salar) freshwater presmolts and seawater postsmolts maintained at constant water temperature

Digestibility ofCalanus finmarchicuswax esters in Atlantic salmon (Salmo salar) freshwater presmolts and seawater postsmolts maintained at constant water temperature

Intestinal fatty acid‐binding protein variation associated with variation in the response of plasma lipoproteins to dietary fibre

Lipid-Lowering Efficacy of Piperine From Piper Nigrum L. In High-Fat Diet and Antithyroid Drug-Induced Hypercholesterolemic Rats

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