Nutrition Adequacy Therapeutic Enhancement in the Critically Ill: A Randomized Double‐Blind, Placebo‐Controlled Trial of the Motilin Receptor Agonist Camicinal (GSK962040): The NUTRIATE Study

Deane, Adam M.; Lamontagne, François; Dukes, George E.; Neil, David; Vasist, Lakshmi; Barton, Matthew E.; Hacquoil, Kimberley; Ou, Xiaoling; Richards, Duncan; Stelfox, Henry T.; Mehta, Sangeeta; Day, Andrew G.; Chapman, Marianne J.; Heyland, Daren K.

doi:10.1002/jpen.1038

Cited by 19 publications

(33 citation statements)

References 31 publications

(55 reference statements)

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“…After eliminating duplicates, applying the inclusion and exclusion criteria, consulting the bibliographies of the selected articles and consulting with experts (Figure 1), 23 documents were selected [11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33] (Table 1). Two articles by Brown et al [15,34] were selected; although they presented different objectives of study, the population analyzed was the same, and adherence results were not different between them, and therefore, only one was accepted for review [15].…”

Section: Resultsmentioning

confidence: 99%

“…Study design included seven comparative studies [11,13,22,23,25,30,31] and 16 clinical trials [12,14,15,16,17,18,19,20,21,24,26,27,28,29,32,33], all written in English and developed in 10 different countries, with the United Kingdom [17,19,20,21,29,32,33] and Japan [11,23,26,28,30,31] contributing the most work.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding EN type, 11 studies involved partial enteral nutrition (PEN) [11,13,15,16,19,21,23,25,28,29,32], five studies involved exclusive enteral nutrition (EEN) [14,18,24,27,33] and seven studies involved different combinations of PEN and EEN [12,17,20,22,26,30,31].…”

Section: Resultsmentioning

confidence: 99%

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Compliance and Adherence to Enteral Nutrition Treatment in Adults: A Systematic Review

et al. 2019

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Objective: To review the scientific literature that has verified and/or assessed compliance and adherence to enteral nutrition (EN) in adult patients. Method: This study involved a critical analysis of articles retrieved from MEDLINE (PubMed), The Cochrane Library, Embase, Scopus and Web of Science using the terms “Treatment Adherence and Compliance” and “Enteral Nutrition”, applying the filters “Comparative Study” or “Clinical Trial”, “Humans” and “Adults”. Date of the search: 25 October 2018. Results: A total of 512 references were retrieved, of which 23 documents were selected after applying the inclusion and exclusion criteria. The techniques measuring adherence to EN were determined by dietary intake, self-reporting, counts of leftover containers or presence of complications; however, in no case were validated questionnaires used. The time and periodicity of the assessment presented very heterogeneous results, with measurement predominantly being done at the beginning and at the end of the study. The best adherence rates were obtained in hospitalized patients (approximately 80%). Conclusions: Frequent and regular monitoring of the adherence of patients under prolonged treatment with EN is necessary, and the use of measurement techniques that allow obtaining information on the causes of non-adherence facilitates early interventions to optimize treatment outcomes. Patient and/or caregiver education in the management of EN and the intervention of the community pharmacy in monitoring patients can be key to improving the adherence to EN.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Compliance and Adherence to Enteral Nutrition Treatment in Adults: A Systematic Review

et al. 2019

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“…In a single‐center study of 23 critically ill patients with established feed intolerance, a single dose of the motilin receptor agonist, camicinal, when compared with placebo, appeared to accelerate gastric emptying and increase carbohydrate absorption . In a subsequent international multicenter, parallel‐group, blinded, randomized controlled trial of 84 critically ill patients, preemptive administration of enteral camicinal did not significantly augment the provision of goal enteral nutrition . Based on these data, non‐macrolide motilin receptor agonists, which are not currently available, may have a future role as treatment for patients with established feed intolerance, but they do not appear effective as a preemptive strategy to prevent enteral feed intolerance.…”

Section: Drug Therapiesmentioning

confidence: 99%

Pathophysiology and Treatment of Gastrointestinal Motility Disorders in the Acutely Ill

et al. 2018

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Gastrointestinal dysmotility causes delayed gastric emptying, enteral feed intolerance, and functional obstruction of the small and large intestine, the latter functional obstructions being frequently termed ileus and Ogilvie syndrome, respectively. In addition to meticulous supportive care, drug therapy may be appropriate in certain situations. There is, however, considerable variation among individuals regarding what gastric residual volume identifies gastric dysmotility and would encourage use of a promotility drug. While the administration of either metoclopramide or erythromycin is supported by evidence it appears that, dual‐drug therapy (erythromycin and metoclopramide) reduces the rate of treatment failure. There is a lack of evidence to guide drug therapy of ileus, but neither erythromycin nor metoclopramide appear to have a role. Several drugs, including ghrelin agonists, highly selective 5‐hydroxytryptamine receptor agonists, and opiate antagonists are being studied in clinical trials. Neostigmine, when infused at a relatively slow rate in patients receiving continuous hemodynamic monitoring, may alleviate the need for endoscopic decompression in some patients.

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“…Due to concerns about adverse effects of erythromycin, there is a considerable interest in the use of nonantibiotic motilin agonists. The pre-emptive administration of such motilin receptor agonist had a negligible effect on nutrition provision in a recent multicentre clinical trial [34].…”

Section: Gi Motility Drugsmentioning

confidence: 95%

Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine

Blaser¹,

Preiser²,

Fruhwald³

et al. 2020

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Background: Gastrointestinal (GI) dysfunction is frequent in the critically ill but can be overlooked as a result of the lack of standardization of the diagnostic and therapeutic approaches. We aimed to develop a research agenda for GI dysfunction for future research. We systematically reviewed the current knowledge on a broad range of subtopics from a specific viewpoint of GI dysfunction, highlighting the remaining areas of uncertainty and suggesting future studies. Methods: This systematic scoping review and research agenda was conducted following successive steps: (1) identify clinically important subtopics within the field of GI function which warrant further research; (2) systematically review the literature for each subtopic using PubMed, CENTRAL and Cochrane Database of Systematic Reviews; (3) summarize evidence for each subtopic; (4) identify areas of uncertainty; (5) formulate and refine study proposals that address these subtopics; and (6) prioritize study proposals via sequential voting rounds.

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Nutrition Adequacy Therapeutic Enhancement in the Critically Ill: A Randomized Double‐Blind, Placebo‐Controlled Trial of the Motilin Receptor Agonist Camicinal (GSK962040): The NUTRIATE Study

Abstract: The incidence of feed intolerance was low in both groups. In this cohort the preemptive administration of enteral camicinal did not significantly augment the provision of goal EN.

Cited by 19 publications

References 31 publications

Compliance and Adherence to Enteral Nutrition Treatment in Adults: A Systematic Review

Compliance and Adherence to Enteral Nutrition Treatment in Adults: A Systematic Review

Pathophysiology and Treatment of Gastrointestinal Motility Disorders in the Acutely Ill

Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine

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