Nutrigenomics in Parkinson’s disease: diversity of modulatory actions of polyphenols on epigenetic effects induced by toxins

Rodrigues-Costa, Moara; Fernandes, Matheus Santos de Sousa; Santos, Gabriela Carvalho Jurema; Gonçalves, Lílian Vanessa da Penha; Andrade-da-Costa, Belmira Lara da Silveira

doi:10.1080/1028415x.2021.2017662

Cited by 2 publications

(2 citation statements)

References 113 publications

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“…Nutrigenomics refers to the study of the impact of specific nutrients, dietary components or entire diet on gene expression and gene regulation (Patil et al, 2022). Although many perspectives of molecular basis of chronic diseases such as metabolomics, nutrigenomics, transcriptomics are emerging and being pursued, nutrigenomics is currently the most important and widely applied (Rodrigues-Costa et al, 2021;Patil et al, 2022).…”

Section: Nutrigenomics: the Promise And Application In Environmental ...mentioning

confidence: 99%

Environmental Pollutants and Oxidative Stress in Terrestrial and Aquatic Organisms: Examination of the Total Picture and Implications for Human Health

et al. 2022

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There is current great international concern about the contribution of environmental pollution to the global burden of disease particularly in the developing, low- and medium-income countries. Industrial activities, urbanization, developmental projects as well as various increased anthropogenic activities involving the improper generation, management and disposal of pollutants have rendered today’s environment highly polluted with various pollutants. These pollutants include toxic metals (lead, cadmium, mercury, arsenic), polycyclic aromatic hydrocarbons, polychlorinated biphenyls, pesticides and diesel exhaust particles most of which appear to be ubiquitous as well as have long-term environmental persistence with a wide range of toxicities such as oxidative stress among others. Oxidative stress, which may arise from increased production of damaging free radicals emanating from increased pollutant burden and depressed bioavailability of antioxidant defenses causes altered biochemical and physiological mechanisms and has been implicated in all known human pathologies most of which are chronic. Oxidative stress also affects both flora and fauna and plants are very important components of the terrestrial environment and significant contributors of nutrients for both man and animals. It is also remarkable that the aquatic environment in which sea animals and creatures are resident is also highly polluted, leading to aquatic stress that may affect the survival of the aquatic animals, sharing in the oxidative stress. These altered terrestrial and aquatic environments have an overarching effect on human health. Antioxidants neutralize the damaging free radicals thus, they play important protective roles in the onset, progression and severity of the unmitigated generation of pollutants that ultimately manifest as oxidative stress. Consequently, human health as well as that of aquatic and terrestrial organisms may be protected from environmental pollution by mitigating oxidative stress and employing the principles of nutritional medicine, essentially based on antioxidants derived mainly from plants, which serve as the panacea of the vicious state of environmental pollutants consequently, the health of the population. Understanding the total picture of oxidative stress and integrating the terrestrial and aquatic effects of environmental pollutants are central to sustainable health of the population and appear to require multi-sectoral collaborations from diverse disciplinary perspectives; basically the environmental, agricultural and health sectors.

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Section: Nutrigenomics: the Promise And Application In Environmental ...mentioning

confidence: 99%

Environmental Pollutants and Oxidative Stress in Terrestrial and Aquatic Organisms: Examination of the Total Picture and Implications for Human Health

et al. 2022

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“…Curcumin and apigenin, two naturally occurring polyphenols, have recently been linked to the histone modification process. Curcumin has been shown to promote HDAC-mediated acetylation-deacetylation balance while apigenin trigger histone H3 on lysine 9 (H3K9) and histone H4 on lysine 12 (H4K12) acetylation ( Rodrigues-Costa et al, 2021 ). Curcumin therapy decreased apoptosis and improved motor impairments in a PARK7-knockout rat model of Parkinson's disease by targeting HDACs ( Chiu et al, 2013 ).…”

Section: Nutriepigenomics and Parkinson’s Diseasementioning

confidence: 99%

Integrating nutriepigenomics in Parkinson’s disease management: New promising strategy in the omics era

Razali

Algantri²,

Loh

et al. 2022

IBRO Neuroscience Reports

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Nutrigenomics in Parkinson’s disease: diversity of modulatory actions of polyphenols on epigenetic effects induced by toxins

Cited by 2 publications

References 113 publications

Environmental Pollutants and Oxidative Stress in Terrestrial and Aquatic Organisms: Examination of the Total Picture and Implications for Human Health

Environmental Pollutants and Oxidative Stress in Terrestrial and Aquatic Organisms: Examination of the Total Picture and Implications for Human Health

Integrating nutriepigenomics in Parkinson’s disease management: New promising strategy in the omics era

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