Nutrigenomic regulation of adipose tissue development — role of retinoic acid: A review

Wang, Bo; Yang, Qiyuan; Harris, Corrine L.; Nelson, Mark L.; Busboom, J. R.; Zhu, Mei‐Jun; Du, Min

doi:10.1016/j.meatsci.2016.04.003

Cited by 68 publications

(62 citation statements)

References 101 publications

(120 reference statements)

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“…Most of these experiments compared lean, fast growing breeds such as Yorkshire or Landrace with indigenous Chinese or Korean breeds [69,70,71,72], or with European local breeds [73], which have an overall fattier phenotype. There is a common trend among these results, which is the overexpression in the leaner breeds of genes related to: (i) muscle differentiation and contraction along with changes in gene expression which promote; (ii) glucose production via gluconeogenesis and glycolysis; but also (iii) lipid catabolism; and (iv) mitochondria function.…”

Section: The Molecular Basis Of Imf Content and Compositionmentioning

confidence: 99%

“…Housekeeping ncRNAs include transfer RNAs (tRNAs), ribosomal RNAs (rRNAs), small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs) and are usually expressed constitutively, while regulatory RNAs consists of piwi-interacting RNAs (piRNAs), microRNAs (miRNAs), and long non-coding RNAs (lncRNAs) [76]. Interaction between coding genes and miRNA in pigs differing in growth and fat deposition have been assessed and networks of integrated regulation have been built [71]. A catalogue of lncRNAs related to adipocyte differentiation is available in humans and mice, some of which have been validated by functional studies [77].…”

Section: The Molecular Basis Of Imf Content and Compositionmentioning

confidence: 99%

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Genetic Marker Discovery in Complex Traits: A Field Example on Fat Content and Composition in Pigs

Pena

Ros‐Freixedes

Tör

et al. 2016

IJMS

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Among the large number of attributes that define pork quality, fat content and composition have attracted the attention of breeders in the recent years due to their interaction with human health and technological and sensorial properties of meat. In livestock species, fat accumulates in different depots following a temporal pattern that is also recognized in humans. Intramuscular fat deposition rate and fatty acid composition change with life. Despite indication that it might be possible to select for intramuscular fat without affecting other fat depots, to date only one depot-specific genetic marker (PCK1 c.2456C>A) has been reported. In contrast, identification of polymorphisms related to fat composition has been more successful. For instance, our group has described a variant in the stearoyl-coA desaturase (SCD) gene that improves the desaturation index of fat without affecting overall fatness or growth. Identification of mutations in candidate genes can be a tedious and costly process. Genome-wide association studies can help in narrowing down the number of candidate genes by highlighting those which contribute most to the genetic variation of the trait. Results from our group and others indicate that fat content and composition are highly polygenic and that very few genes explain more than 5% of the variance of the trait. Moreover, as the complexity of the genome emerges, the role of non-coding genes and regulatory elements cannot be disregarded. Prediction of breeding values from genomic data is discussed in comparison with conventional best linear predictors of breeding values. An example based on real data is given, and the implications in phenotype prediction are discussed in detail. The benefits and limitations of using large SNP sets versus a few very informative markers as predictors of genetic merit of breeding candidates are evaluated using field data as an example.

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Section: The Molecular Basis Of Imf Content and Compositionmentioning

confidence: 99%

Section: The Molecular Basis Of Imf Content and Compositionmentioning

confidence: 99%

Genetic Marker Discovery in Complex Traits: A Field Example on Fat Content and Composition in Pigs

Pena

Ros‐Freixedes

Tör

et al. 2016

IJMS

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“…35,36 Thus, it appears that the protein status of these transcriptional factors, Values are expressed as means ± SD of six to eight rats, except for plasma adiponectin, four to six rats, and mRNA expression, four to five rats from each group. In other words, the values/groups bearing common alphabets/superscripts are not statistically different.…”

Section: Discussionmentioning

confidence: 99%

“…This is quite intriguing, because C/EBP is required for adipocyte differentiation, as it triggers the PPARγ expression, which is an essential transcription factor of adipogenic differentiation process. 35,36 Thus, it appears that the protein status of these transcriptional factors, rather mRNA levels, may possibly explain the adipocyte differentiation. Nevertheless, it is evident that the observed elevation of ZFP423 mRNA is suggestive of increased preadipocyte differentiation to house triglyceride, arising out of excess fructose ingestion and thus resulting in adipocyte hypertrophy of RPWAT.…”

Section: Discussionmentioning

confidence: 99%

Vitamin A and its metabolic pathway play a determinant role in high‐fructose‐induced triglyceride accumulation of the visceral adipose depot of male Wistar rats

Reddy

Mahesh

Munikumar

et al. 2019

Cell Biochemistry & Function

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Here, we tested a hypothesis that vitamin A and/or its metabolic pathways are involved in the high-fructose-mediated alteration in adipose tissue biology. For this purpose, weanling male Wistar rats were provided with one of the following diets: control (C), control with vitamin A deficiency (C-VAD), high fructose (HFr), and HFr with VAD (HFr-VAD) for 16 weeks, except that half of the C-VAD diet-fed rats were shifted to HFr diet (C-VAD(s)HFr), after 8-week period. Compared with control, feeding of HFr diet significantly increased the triglyceride content (P ≤ .01) and thus adipocyte size (hypertrophy) (P ≤ .001) in visceral adipose depot; retroperitoneal white adipose tissue (RPWAT) and these changes were corroborated with de novo lipogenesis, as evidenced by the increased glycerol-3-phosphate dehydrogenase activity (P ≤ .01) and up-regulation of lipogenic pathway transcripts, fructose transporter, and aldehyde dehydrogenase 1 A1. On the contrary, the absence of vitamin A in the HFr diet (HFr-VAD) failed to exert these changes; however, it induced adipocyte hyperplasia. Further, vitamin A deficiency-mediated changes were reversed by replenishment, as evident from the group that was shifted from C-VAD to HFr diet.In conclusion, vitamin A and its metabolic pathway play a key determinant role in the high-fructose-induced triglyceride accumulation and adipocyte hypertrophy of visceral white adipose depot.Significance of the study: Here, we report the metabolic impact of high-fructose feeding under vitamin A-sufficient and vitamin A-deficient conditions. Feeding of high-fructose diet induced triglyceride accumulation and adipocyte hypertrophy of the visceral white adipose depots. These changes corroborated with augmented expression of vitamin A and lipid metabolic pathway genes. Contrarily, absence of vitamin A in the high-fructose diet did not elicit such responses, while vitamin A

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“…GeneModuleMembership, GeneTraitSignificance and expression pattern of hub genes were showed. The cut-off thresholds of hub genes were geneModuleMembership > 0.9 and geneTraitSignificance > 0.5, and all hub genes are significantly down-regulated metabolite of vitamin A, retinoic acid plays a regulatory role in proliferation and differentiation [52], and it has a profound impact on adipogenesis by activating retinoic acid receptors [53]. It is important to note that retinoic acid receptor signaling pathway may play a role in immune suppression.…”

Section: Table 2 the List Of Sixteen Hub Genes Identified In Gene Expmentioning

confidence: 99%

Identification of hub genes in papillary thyroid carcinoma: robust rank aggregation and weighted gene co-expression network analysis

et al. 2020

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Background: Papillary thyroid carcinoma (PTC), which is the most common endocrine malignancy, has been steadily increasing worldwide in incidence over the years, while mechanisms underlying the pathogenesis and diagnostic for PTC are incomplete. The purpose of this study is to identify potential biomarkers for diagnosis of PTC, and provide new insights into pathogenesis of PTC.Methods: Based on weighted gene co-expression network analysis, Robust Rank Aggregation, functional annotation, GSEA and DNA methylation, were employed for investigating potential biomarkers for diagnosis of PTC.Results: Black and turquoise modules were identified in the gene co-expression network constructed by 1807 DEGs that from 6 eligible gene expression profiles of Gene Expression Omnibus database based on Robust Rank Aggregation and weighted gene co-expression network analysis. Hub genes were significantly down-regulated and the expression levels of the hub genes were different in different stages in hub gene verification. ROC curves indicated all hub genes had good diagnostic value for PTC (except for ABCA6 AUC = 89.5%, the 15 genes with AUC > 90%). Methylation analysis showed that hub gene verification ABCA6, ACACB, RMDN1 and TFPI were identified as differentially methylated genes, and the decreased expression level of these genes may relate to abnormal DNA methylation. Moreover, the expression levels of 8 top hub genes were correlated with tumor purity and tumor-infiltrating immune cells. These findings, including functional annotations and GSEA provide new insights into pathogenesis of PTC. Conclusions:The hub genes and methylation of hub genes may as potential biomarkers provide new insights for diagnosis of PTC, and all these findings may be the direction to study the mechanisms underlying of PTC in the future.

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Nutrigenomic regulation of adipose tissue development — role of retinoic acid: A review

Cited by 68 publications

References 101 publications

Genetic Marker Discovery in Complex Traits: A Field Example on Fat Content and Composition in Pigs

Genetic Marker Discovery in Complex Traits: A Field Example on Fat Content and Composition in Pigs

Vitamin A and its metabolic pathway play a determinant role in high‐fructose‐induced triglyceride accumulation of the visceral adipose depot of male Wistar rats

Identification of hub genes in papillary thyroid carcinoma: robust rank aggregation and weighted gene co-expression network analysis

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