Nutrients as novel therapeutic approaches for metabolic disturbances in polycystic ovary syndrome

Mansour, Asieh; Hosseini, Saeed; Larijani, Bagher; Mohajeri-Tehrani, Mohammad Reza

doi:10.17179/excli2016-422

Cited by 8 publications

(4 citation statements)

References 66 publications

(116 reference statements)

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“…The etiology of polycystic ovary syndrome is not clearly described, but it is well-known that PCOS is one of the most frequent endocrinological diseases in women of reproductive age [ 1 , 2 ]. PCOS has various effects on blood circulation.…”

Section: Discussionmentioning

confidence: 99%

“…Polycystic ovary syndrome (PCOS) is one of the most common endocrinological diseases among women of childbearing potential [ 1 , 2 , 3 ]. Its prevalence averages 8–13% [ 1 , 2 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Polycystic ovary syndrome (PCOS) is one of the most common endocrinological diseases among women of childbearing potential [ 1 , 2 , 3 ]. Its prevalence averages 8–13% [ 1 , 2 , 4 ]. It has various symptoms, like ovarian dysfunction, induced by the disturbed secretion of gonadotropin-releasing hormone (GnRH), thus the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are insufficient.…”

Section: Introductionmentioning

confidence: 99%

“…Some cysts can produce androgens, which cause virilization, hyperandrogenism, or hyperandrogenemia. In many cases, insulin resistance, dyslipidemia, obesity, hyperinsulinemia, metabolic syndrome, type 2 diabetes, high blood pressure, and cardiovascular diseases (CVD) can occur [ 1 , 2 , 3 , 5 ]. Several CVD markers, predictors, and risk factors can be elevated or presented in PCOS, like endothelial dysfunction, C-reactive protein, and coronary artery calcium scores [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Estradiol Valerate Affects Hematological and Hemorheological Parameters in Rats

et al. 2022

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Polycystic ovary syndrome (PCOS) is one of the most common endocrinological diseases in women. Although the risk of cardiovascular diseases is high in PCOS, the number of scientific publications describing hemorheological changes is not significant. We aimed to perform a comprehensive hematological and micro-rheological study on experimentally induced PCOS in rats.Wistar rats were divided into control (n = 9) and PCOS groups (n = 9), in which animals received single-dose estradiol valerate. Measurements were carried out before treatment and monthly for four months. Bodyweight, blood glucose concentration, hematological parameters, red blood cell (RBC) deformability, and aggregation were measured. A histological examination of the ovary was performed at the end of the experiment. The blood glucose level and the bodyweight were significantly elevated vs. base in the PCOS group. A significant decrease was seen in RBC count, hemoglobin, and hematocrit. The maximal elongation index showed a significant increase. PCOS also resulted in a significant increase in RBC aggregation index parameters. The histological and hormone examinations confirmed developed PCOS. The administration of estradiol valerate caused significant changes during the examined period in hematological and hemorheological parameters. Our results draw attention to the possible usefulness of micro-rheological investigations in further studies on PCOS.

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Section: Discussionmentioning

confidence: 99%

“…Polycystic ovary syndrome (PCOS) is one of the most common endocrinological diseases among women of childbearing potential [ 1 , 2 , 3 ]. Its prevalence averages 8–13% [ 1 , 2 , 4 ].…”

Section: Introductionmentioning

confidence: 99%