Nutrients and gastric cancer risk. A population‐based case‐control study in Sweden

Hansson, Lars‐Erik; Nykén, Olof; Beagström, Reinhold; Wolk, Alicja; Lindgren, Anders; Baron, John A.; Adami, Hans‐Olov

doi:10.1002/ijc.2910570505

Cited by 125 publications

(59 citation statements)

References 27 publications

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“…In the General Population Trial, it is not clear whether a specific component or a combination of components of the supplement were responsible for the reduction in the incidence gastric carcinoma. We did not observe an inverse association between vitamin E, folate, ␣-carotene, lutein plus zeaxanthin, ␤-cryptoxanthin, and dietary fiber and the risk 19,21 One case-control study reported protective effects for lutein and lycopene but not for ␣-carotene. 22 Only vitamin C was associated with a decreased risk of gastric carcinoma; however, after adjustment for several confounders and exclusion of first-year and second-year cases, this association weakened and became nonsignificant.…”

Section: Discussioncontrasting

confidence: 78%

Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma

Botterweck

Brandt

Goldbohm³

2000

Cancer

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Section: Discussioncontrasting

confidence: 78%

Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma

Botterweck

Brandt

Goldbohm³

2000

Cancer

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“…Epidemiological data suggest that a higher antioxidant intake and/or higher plasma concentrations of antioxidants may protect against chronic diseases such as coronary artery disease (CAD) (Rimm et al, 1993;Osganian et al, 2003) and cancer (Hansson et al, 1994;Mark et al, 2000). Therefore, a sufficient status of antioxidants (ascorbic acid, alpha-tocopherol, beta-carotene, selenium, and coenzyme Q10) may help to optimize antioxidant defence.…”

Section: Introductionmentioning

confidence: 99%

Selenium and antioxidant vitamin status of elderly German women

et al. 2005

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Objective: Low antioxidant intake and status have been shown to be associated with an elevated risk for various diseases. Data on the status of antioxidant vitamins, selenium and coenzyme Q10 of younger female seniors are scarce. The aim of this study was to assess the status of these antioxidants, as well as influencing factors such as dietary intake, anthropometric data and educational level in female seniors (60-70 years) in Germany. Design: Dietary intake of alpha-tocopherol, beta-carotene and ascorbic acid was determined by a 3-day diet record. Serum concentrations of alpha-tocopherol, beta-carotene, ascorbic acid, selenium and coenzyme Q10 were measured. Anthropometric measures, socioeconomic and educational status were assessed. Setting: In total, 178 elderly women without severe diseases in the region of Hannover, Germany, were included in the study. The mean (7s.d.) age and BMI of the women was 63.2 (2.73) years and 25.6 (3.77) kg/m 2 , respectively. The study participants were generally better educated than the overall German female population. Results: Dietary intake of the ascorbic acid and alpha-tocopherol was below RDA in six and 75% of the women, respectively. In comparison to estimated desirable serum concentrations of alpha-tocopherol, ascorbic acid, beta-carotene and selenium, lower concentrations were found in 23, 1, 6, and 39% of the women, respectively. Ascorbic acid (r ¼ 0.205, P ¼ 0.009) and betacarotene (r ¼ 0.173, P ¼ 0.025) intake were significantly associated with serum concentrations. Beta-carotene concentrations were influenced by the type of diet, BMI, and school education (R 2 ¼ 0.128, Po0.001). Serum selenium was positively associated with alcohol intake (r ¼ 0.229, P ¼ 0.003). Neither employment nor vocational training was predictive for the serum concentrations of antioxidant vitamins, selenium or coenzyme Q10. Conclusions: Poor status of selenium and alpha-tocopherol is highly prevalent even among younger, well-educated female seniors, whereas ascorbic acid and beta-carotene status seems sufficient in most women.

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“…Several case -control studies have shown strong inverse associations between GC risk and higher consumption of some of these nutrients (Buiatti et al, 1990(Buiatti et al, , 1991Gonzalez et al, 1994;Hansson et al, 1994;Ekstrom et al, 2000). Results from prospective dietary studies are conflicting and show either a strong protection (Zheng et al, 1995) or no clear inverse associations between the dietary intake of carotenoids and GC risk (Ocke et al, 1995;Botterweck et al, 2000b).…”

mentioning

confidence: 99%

Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition

Jenab¹,

Riboli²,

Ferrari³

et al. 2006

Br J Cancer

111

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Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. Its aetiology may involve dietary antioxidant micronutrients such as carotenoids and tocopherols. The objective of this study was to determine the association of plasma levels of seven common carotenoids, their total plasma concentration, retinol and a-and g-tocopherol, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 countries. A secondary objective was to determine the association of total sum of carotenoids, retinol and a-tocopherol on GCs by anatomical subsite (cardia/noncardia) and histological subtype (diffuse/intestinal). Analytes were measured by high-performance liquid chromatography in prediagnostic plasma from 244 GC cases and 645 controls matched by age, gender, study centre and date of blood donation. Conditional logistic regression models adjusted by body mass index, total energy intake, smoking and Helicobacter pylori infection status were used to estimate relative cancer risks. After an average 3.2 years of follow-up, a negative association with GC risk was observed in the highest vs the lowest quartiles of plasma b-cryptoxanthin (odds ratio (OR) ¼ 0.53, 95% confidence intervals (CI) ¼ 0.30-0.94, P trend ¼ 0.006), zeaxanthin (OR ¼ 0.39, 95% CI ¼ 0.22-0.69, P trend ¼ 0.005), retinol (OR ¼ 0.55, 95% CI ¼ 0.33-0.93, P trend ¼ 0.005) and lipid-unadjusted a-tocopherol (OR ¼ 0.59, 95% CI ¼ 0.37-0.94, P trend ¼ 0.022). For all analytes, no heterogeneity of risk estimates or significant associations were observed by anatomical subsite. In the diffuse histological subtype, an inverse association was observed with the highest vs lowest quartile of lipid-unadjusted a-tocopherol (OR ¼ 0.26, 95% CI ¼ 0.11-0.65, P trend ¼ 0.003). These results show that higher plasma concentrations of some carotenoids, retinol and a-tocopherol are associated with reduced risk of GC.

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Nutrients and gastric cancer risk. A population‐based case‐control study in Sweden

Cited by 125 publications

References 27 publications

Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma

Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma

Selenium and antioxidant vitamin status of elderly German women

Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition

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