Nutrient vessels in long bones

Brookes, Murray; Revell, William J.

doi:10.1007/978-1-4471-1543-4_2

Cited by 3 publications

(28 citation statements)

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“…In addition to the nutrient artery, the blood supply of many flat bones is also derived from periosteal vessels. With age, long bones can sometimes also become increasingly dependent on periosteal vessels (Brookes and Revell, 1998).…”

Section: Vascularitymentioning

confidence: 99%

“…Postnatally, nutrient arteries supply the diaphysis and central portion of the metaphysis with blood whereas the epiphyseal arteries supply only the epiphyses. The metaphyseal arteries supply the peripheral regions of the metaphysis (Brookes and Revell, 1998).…”

Section: Vascularitymentioning

confidence: 99%

“…In addition, during early postnatal development in the epiphyseal region, cartilage canals persisting from the fetal period are a source of nutrition for the epiphyses. Cartilage canals may also play a role in the appearance of the secondary center of ossification (Kincaid and Van Sickle, 1983; Brookes and Revell, 1998).…”

Section: Vascularitymentioning

confidence: 99%

“…The main nutrient artery is surrounded by several venules that merge into one or two large nutrient veins. In fact, in bone, many openings or foramina give exit to veins alone so that the number of nutrient veins draining a bone usually exceeds the number of the nutrient arteries supplying it (Brookes and Revell, 1998).…”

Section: Vascularitymentioning

confidence: 99%

See 3 more Smart Citations

Species comparison of postnatal bone growth and development

Zoetis

Tassinari

Bagi

et al. 2003

Birth Defects Research Pt B

150

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Section: Vascularitymentioning

confidence: 99%

Section: Vascularitymentioning

confidence: 99%

Section: Vascularitymentioning

confidence: 99%

Section: Vascularitymentioning

confidence: 99%

See 2 more Smart Citations

Species comparison of postnatal bone growth and development

Zoetis

Tassinari

Bagi

et al. 2003

Birth Defects Research Pt B

150

View full text Add to dashboard Cite

“…In humans, younger individuals are more at risk of medullary infarction, because the long bones are more reliant on the nutrient artery at a young age, with a relative shift to periosteal blood occurring with maturity; the same may be true for dogs. Dogs also have a poor medullary collateral blood supply, which has been suggested to predispose to infarction .…”

Section: Discussionmentioning

confidence: 99%

Suspected intramedullary bone infarct subsequent to tibial plateau levelling osteotomy in a dog

Newman

Johnson

2015

Aust Veterinary J

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Systematic review on the application of 3D-bioprinting technology in orthoregeneration: current achievements and open challenges

et al. 2022

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Background Joint degeneration and large or complex bone defects are a significant source of morbidity and diminished quality of life worldwide. There is an unmet need for a functional implant with near-native biomechanical properties. The potential for their generation using 3D bioprinting (3DBP)-based tissue engineering methods was assessed. We systematically reviewed the current state of 3DBP in orthoregeneration. Methods This review was performed using PubMed and Web of Science. Primary research articles reporting 3DBP of cartilage, bone, vasculature, and their osteochondral and vascular bone composites were considered. Full text English articles were analyzed. Results Over 1300 studies were retrieved, after removing duplicates, 1046 studies remained. After inclusion and exclusion criteria were applied, 114 articles were analyzed fully. Bioink material types and combinations were tallied. Cell types and testing methods were also analyzed. Nearly all papers determined the effect of 3DBP on cell survival. Bioink material physical characterization using gelation and rheology, and construct biomechanics were performed. In vitro testing methods assessed biochemistry, markers of extracellular matrix production and/or cell differentiation into respective lineages. In vivo proof-of-concept studies included full-thickness bone and joint defects as well as subcutaneous implantation in rodents followed by histological and µCT analyses to demonstrate implant growth and integration into surrounding native tissues. Conclusions Despite its relative infancy, 3DBP is making an impact in joint and bone engineering. Several groups have demonstrated preclinical efficacy of mechanically robust constructs which integrate into articular joint defects in small animals. However, notable obstacles remain. Notably, researchers encountered pitfalls in scaling up constructs and establishing implant function and viability in long term animal models. Further, to translate from the laboratory to the clinic, standardized quality control metrics such as construct stiffness and graft integration metrics should be established with investigator consensus. While there is much work to be done, 3DBP implants have great potential to treat degenerative joint diseases and provide benefit to patients globally.

show abstract

Nutrient vessels in long bones

Cited by 3 publications

References 0 publications

Species comparison of postnatal bone growth and development

Species comparison of postnatal bone growth and development

Suspected intramedullary bone infarct subsequent to tibial plateau levelling osteotomy in a dog

Systematic review on the application of 3D-bioprinting technology in orthoregeneration: current achievements and open challenges

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