Nutrient partitioning during treatment of tuberculosis: gain in body fat mass but not in protein mass

Schwenk, Achim; Hodgson, Lisa; Wright, Antony; Ward, Leigh C.; Rayner, Charlotte F. J.; Grubnic, Sisa; Griffin, George E.; Macallan, Derek C.

doi:10.1093/ajcn/79.6.1006

Cited by 58 publications

(56 citation statements)

References 30 publications

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“…38 Nurses should take particular note of underweight tuberculosis patients, recognizing that being underweight is a risk factor for relapse and encouraging aggressive nutritional support. 39 Also, because functional recovery often lags behind microbiological cure, the aim of nutritional intervention should be to restore lean tissue. 23,39 Nurses should also encourage patients to engage in physical activity to counter the loss of muscle mass and subsequent fatigue.…”

Section: Nutritionmentioning

confidence: 99%

“…39 Also, because functional recovery often lags behind microbiological cure, the aim of nutritional intervention should be to restore lean tissue. 23,39 Nurses should also encourage patients to engage in physical activity to counter the loss of muscle mass and subsequent fatigue. Advocating for a nutritionist and physical therapist to evaluate a patient with tuberculosis to make patient-specific recommendations would be an appropriate action for nurses.…”

Section: Nutritionmentioning

confidence: 99%

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Tuberculosis: Pathophysiology, Clinical Features, and Diagnosis

Knechel

2009

Critical Care Nurse

101

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Section: Nutritionmentioning

confidence: 99%

Section: Nutritionmentioning

confidence: 99%

Tuberculosis: Pathophysiology, Clinical Features, and Diagnosis

Knechel

2009

Critical Care Nurse

101

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“…Wasting has been associated with infection in humans (Macallan 1999, Paton & Ng 2006, ruminants (Harris & Barletta 2001), and fish (MacKenzie 1988, Inglis et al 1993) among others. Once called 'consumption,' the mechanisms behind the loss of body mass associated with tuberculosis are poorly understood but may reflect decreased appetite, altered metabolism, and demands of the inflammatory and immune response (Schwenk et al 2004). Johne's disease caused by Mycobacterium avium subsp.…”

Section: Introductionmentioning

confidence: 99%

Influence of nutritional state on the progression and severity of mycobacteriosis in striped bass Morone saxatilis

Jacobs¹,

Rhodes²,

Baya³

et al. 2009

Dis. Aquat. Org.

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Challenge studies with Mycobacterium marinum clearly demonstrate that a poor diet affects the progression and severity of mycobacteriosis in striped bass Morone saxatilis. Fish (n = 512 total, wt = 65 ± 15 g) were inoculated intraperitoneally with 10 4 colony-forming units (CFU) g -1 body weigth (BW) or a physiological saline solution (controls) and evaluated for 8 mo. Inoculated fish fed a low-ration diet (0.15% BW d -1 ) developed a severe, systemic infection characterized by a high bacterial load (>10 8 CFU g -1 spleen) and poor granuloma formation, which commonly progressed to mortality by 6 wk. In contrast, inoculated fish fed an adequate ration diet (1% BW d -1 ) developed classic granulomatous inflammation of reduced severity and total body energy similar to that found in uninoculated controls (p > 0.05). After 4 wk, fish fed adequate rations maintained an equilibrium state throughout the study period, even though 10 6 CFU g -1 spleen mycobacteria were consistently cultured. In a second study, reactivation of an acute inflammatory state was demonstrated by placing previously infected fish on reducing diets (0.073% BW d -1). In both studies, the energetic demand of this disease was only appreciable when associated with active, severe, inflammatory states. To our knowledge, this study is the first to demonstrate the interaction of diet and mycobacteriosis in fish.

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“…Diversas razones podrían explicar el aumento de peso durante el tratamiento antituberculoso, entre ellas, el aumento del apetito e ingesta de alimentos, la reducción de las demandas de energía y la mejora de la eficiencia metabólica entre otras (11,12) ; aunque la ganancia de peso está limitada al aumento de tejido graso (13,14) . Sin embargo, también se debe tomar en cuenta que en los beneficiarios del PANTBC está inherente el aporte nutricional de la canasta alimentaria.…”

Section: Discussionunclassified

Variación del estado nutricional durante el tratamiento antituberculoso en beneficiarios del programa PANTBC

Aparco

Huamán-Espino

Segura

2012

Rev Peru Med Exp Salud Publica

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RESUMENObjetivos. Analizar la variación nutricional de los beneficiarios actuales y pasados del Programa de Alimentación y Nutrición al Paciente Ambulatorio con Tuberculosis y Familia (PANTBC). Materiales y métodos. Se realizó un análi-sis secundario a partir de la valoración antropométrica por medio del índice de masa corporal (IMC) en beneficiarios actuales y pasados del programa PANTBC. Las mediciones se realizaron al inicio, segundo y quinto o sexto mes y se comparó la distribución del estado nutricional al inicio respecto al final (prueba de McNemar-Bowker). Resultados. Se incluyó información de 409 beneficiarios actuales y 110 beneficiarios pasados. Tanto en beneficiarios actuales como pasados se observó disminución progresiva de la condición de bajo peso (IMC<18,5) así como el aumento de la condición de sobrepeso. Los resultados de la tercera medición mostraron que el 57,7% de los beneficiarios actuales que iniciaron con bajo peso terminaron con peso normal, mientras el 20,7% de los que iniciaron con peso normal terminaron con sobrepeso. La comparación del estado nutricional al inicio respecto al final mostró cambios en la distribución (p<0,05). Conclusiones. A lo largo del programa PANTBC existe variación del estado nutricional de los beneficiarios, con la tendencia de pasar de un nivel inferior a otro superior de IMC. Palabras clave: Tuberculosis; Estado nutricional; Índice de masa corporal (fuente: DeCS BIREME). CHANGE IN NUTRITIONAL STATUS OVER THE COURSE OF ANTITUBERCULOSIS TREATMENT IN CURRENT AND PAST BENEFICIARIES OF THE PROGRAM PANTBC ABSTRACT Objectives. Analyze the nutritional changes among current and old beneficiaries of the Food and Nutrition Program for Outpatients with Tuberculosis and their Family (PANTBC, Spanish acronym). Materials and methods.A secondary analysis was conducted based on the anthropometric measurements with the body mass index (BMI) in current and old beneficiaries of the PANTBC program. The measurements were taken at the baseline, second and fifth or sixth month, and the distribution of the nutritional status was analyzed at baseline as compared to the endpoint (McNemar-Bowker test). Results. Information about 409 current beneficiaries and 110 old beneficiaries were included. A progressive decline in low weight as well as an increase in overweight were observed in both current and old beneficiaries (IMC<18.5). The results of the third measurement showed that 57.7% of current beneficiaries who started with low weight ended up with normal weight, while 20.7% of those who started with normal weight ended up with overweight. The analysis of the nutritional status at baseline compared to the endpoint showed changes in distribution (p<0.05). Conclusions. Across the PANTBC program, there is a variation of beneficiaries' nutritional status, showing a tendency to go from a lower level to a higher level of BMI.

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Nutrient partitioning during treatment of tuberculosis: gain in body fat mass but not in protein mass

Cited by 58 publications

References 30 publications

Tuberculosis: Pathophysiology, Clinical Features, and Diagnosis

Tuberculosis: Pathophysiology, Clinical Features, and Diagnosis

Influence of nutritional state on the progression and severity of mycobacteriosis in striped bass Morone saxatilis

Variación del estado nutricional durante el tratamiento antituberculoso en beneficiarios del programa PANTBC

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