Nutrient intake in the bovine during early and mid-gestation causes sex-specific changes in progeny plasma IGF-I, liveweight, height and carcass traits

Micke, G.C.; Sullivan, T.M.; Gatford, Kathryn L.; Owens, Julie A.; Perry, V.E.A.

doi:10.1016/j.anireprosci.2010.05.017

Cited by 62 publications

(70 citation statements)

References 65 publications

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“…This positive effect of dam parity on the size of the calf corresponds to other sources (Kertz et al, 1997). On the other hand, maternal metabolic state also affects foetal growth and BW in babies (de Rooij et al, 2006), lambs (Freetly et al, 2000) and calves (Freetly et al, 2000;Micke et al, 2009;Du et al, 2010;Micke et al, 2010). This effect could not be confirmed in the current study.…”

Section: Discussioncontrasting

confidence: 70%

“…Previous work has demonstrated that the factor 'lactation' alters embryo quality compared with non-lactating cows (Leroy et al, 2005), and that exposure of bovine oocytes to NEB conditions in vitro affects glucose homeostasis in early embryonic stages (Van Hoeck et al, 2011 and. The difference in IGF-I corresponds to other reports (Taylor et al, 2004) and is of particular interest, since IGF-I has been proposed as a mediator between maternal energy balance and foetal development (Wathes et al, 1998;Lucy, 2008;Micke et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

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Effects of parity and periconceptional metabolic state of Holstein–Friesian dams on the glucose metabolism and conformation in their newborn calves

Bossaert

Fransén

Langbeen

et al. 2014

Animal

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The metabolic state of pregnant mammals influences the offspring's development and risk of metabolic disease in postnatal life. The metabolic state in a lactating dairy cow differs immensely from that in a non-lactating heifer around the time of conception, but consequences for their calves are poorly understood. The hypothesis of this study was that differences in metabolic state between non-lactating heifers and lactating cows during early pregnancy would affect insulin-dependent glucose metabolism and development in their neonatal calves. Using a mixed linear model, concentrations of glucose, IGF-I and non-esterified fatty acids (NEFAs) were compared between 13 non-lactating heifers and 16 high-yielding dairy cows in repeated blood samples obtained during the 1st month after successful insemination. Calves born from these dams were weighed and measured at birth, and subjected to intravenous glucose and insulin challenges between 7 and 14 days of age. Eight estimators of insulin-dependent glucose metabolism were determined: glucose and insulin peak concentration, area under the curve and elimination rate after glucose challenge, glucose reduction rate after insulin challenge, and quantitative insulin sensitivity check index. Effects of dam parity and calf sex on the metabolic and developmental traits were analysed in a two-way ANOVA. Compared with heifers, cows displayed lower glucose and IGF-I and higher NEFA concentrations during the 1st month after conception. However, these differences did not affect developmental traits and glucose homeostasis in their calves: birth weight, withers height, heart girth, and responses to glucose and insulin challenges in the calves were unaffected by their dam's parity. In conclusion, differences in the metabolic state of heifers and cows during early gestation under field conditions could not be related to their offspring's development and glucose homeostasis.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Effects of parity and periconceptional metabolic state of Holstein–Friesian dams on the glucose metabolism and conformation in their newborn calves

Bossaert

Fransén

Langbeen

et al. 2014

Animal

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“…Some studies have found no effect ). In contrast, other studies have reported a reduction in calf birthweight as a consequence of maternal undernutrition during the second and/or third trimester of pregnancy (Warrington et al 1988;Houghton et al 1990;Freetly et al 2000;Cafe et al 2006;Micke et al 2010aMicke et al , 2010c. In general, reducing calf birthweight by means of maternal dietary restriction does not reduce the incidence of dystocia or calf morbidity.…”

Section: Animal Behaviour and Welfarementioning

confidence: 75%

“…The effects on various measures of adiposity are the focus of the next section, but some studies have observed differences in muscle-related carcass measurements, for example, differences in muscle cross-sectional area (CSA) at slaughter. However, these effects tend to be largely dependent on the sex of the animals, with effects only seen in males or females at a particular stage of their growth (Micke et al 2010a(Micke et al , 2011a. Therefore, it is unclear how permanent these effects are or what mechanisms are involved, although sex steroids (oestrogens and/or androgens) may play a role.…”

Section: Muscle Fibre Numbermentioning

confidence: 99%

“…There is also one cattle study (Long et al 2010a) suggesting that overnutrition throughout gestation results in increased adiposity in older offspring (at 22 vs 19 months). Cattle studies by Micke et al (2010aMicke et al ( , 2011aMicke et al ( , 2011b show that the maternal diet during the first and second trimesters alters growth and carcass development, including fat deposition, from weaning through to slaughter at 22 months of age in a sex-specific manner. One of the main problems in trying to draw conclusions from these various studies is the variability in the timing of the nutritional insult and the age at which the offspring are studied.…”

Section: Body Fat or Adipositymentioning

confidence: 99%

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Epigenetics and developmental programming of welfare and production traits in farm animals

Sinclair

Rutherford

Wallace

et al. 2016

Reprod. Fertil. Dev.

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Abstract. The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the 'developmental origins of health and disease' or 'DOHaD' hypothesis, the primary focus of large-animal studies until quite recently had been biomedical. Attention has since turned towards traits of commercial importance in farm animals. Herein we review the evidence that prenatal risk factors, including suboptimal parental nutrition, gestational stress, exposure to environmental chemicals and advanced breeding technologies, can determine traits such as postnatal growth, feed efficiency, milk yield, carcass composition, animal welfare and reproductive potential. We consider the role of epigenetic and cytoplasmic mechanisms of inheritance, and discuss implications for livestock production and future research endeavours. We conclude that although the concept is proven for several traits, issues relating to effect size, and hence commercial importance, remain. Studies have also invariably been conducted under controlled experimental conditions, frequently assessing single risk factors, thereby limiting their translational value for livestock production. We propose concerted international research efforts that consider multiple, concurrent stressors to better represent effects of contemporary animal production systems.

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Maternal height and its relationship to offspring birth weight and adiposity in 6‐ to 10‐year‐old Maya children from poor neighborhoods in Merida, Yucatan

Azcorra

Dickinson

Banik

2016

American J Phys Anthropol

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Nutrient intake in the bovine during early and mid-gestation causes sex-specific changes in progeny plasma IGF-I, liveweight, height and carcass traits

Cited by 62 publications

References 65 publications

Effects of parity and periconceptional metabolic state of Holstein–Friesian dams on the glucose metabolism and conformation in their newborn calves

Effects of parity and periconceptional metabolic state of Holstein–Friesian dams on the glucose metabolism and conformation in their newborn calves

Epigenetics and developmental programming of welfare and production traits in farm animals

Maternal height and its relationship to offspring birth weight and adiposity in 6‐ to 10‐year‐old Maya children from poor neighborhoods in Merida, Yucatan

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