Nutrient Intake and Dietary Inflammatory Potential in Current and Recovered Anorexia Nervosa

Patsalos, Olivia; Dalton, Bethan; Kyprianou, C.; Firth, Joseph; Shivappa, Nitin; Hébert, James R.; Schmidt, Ulrike; Himmerich, Hubertus

doi:10.3390/nu13124400

Cited by 7 publications

(7 citation statements)

References 95 publications

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“…Despite recovery from AN and weight gain to normal BMI the menstrual cycle does not resume in a considerable number of cases. Recent investigations have demonstrated alterations in inflammatory markers [30][31][32] as well as the gut microbiome and microbial metabolites [33,34] in this patient collective. Research in these areas may help uncover additional therapeutic options for patients with recovered AN in order to reinstate ovulatory cycles and conceive.…”

Section: Discussionmentioning

confidence: 82%

Use of pulsatile gonadotropin-releasing hormone (GnRH) in patients with functional hypothalamic amenorrhea (FHA) results in monofollicular ovulation and high cumulative live birth rates: a 25-year cohort

Quaas

Fischer

et al. 2022

J Assist Reprod Genet

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Purpose To analyze outcomes of pulsatile administration of gonadotropin-releasing hormone (GnRH) in infertile women diagnosed with functional hypothalamic amenorrhea (FHA). Methods A single-center retrospective cohort study was conducted from 1996 to 2020. Sixty-six patients with the diagnosis FHA that underwent therapy using the pulsatile GnRH pump for conception were included and analyzed. The primary outcome was the live birth rate (LBR). Secondary outcomes were the number of dominant follicles, ovulation rate, biochemical pregnancy rate (BPR), clinical pregnancy rate (CPR), miscarriage rate, and multiple pregnancy rate. A matched control group was selected to compare the birth weight of newborn children. Results During the study period, 66 patients with FHA underwent 82 treatments (14 of 66 patients had more than one treatment) and a total of 212 cycles (ovulation induction attempts) using pulsatile GnRH. The LBR per treatment was 65.9%. The ovulation rate per cycle was 96%, and monofollicular ovulation was observed in 75% of cycles. The BPR per treatment was 80.5%, and the cumulative CPR per treatment was 74.4%. The miscarriage rate was 11.5%. One dizygotic twin pregnancy was observed (1.6%). Average newborn birth weight (NBW) from patients with FHA was comparable to the control group. Conclusion(s) In patients with FHA, excellent pregnancy rates were achieved using the subcutaneous GnRH pump. The high cumulative LBR with normal NBW as well as low rates of multiple gestation indicate that the pulsatile GnRH pump represents a safer and more physiologic alternative to ovulation induction with injectable gonadotropins. Trial registration Ethics Committee Northwest and Central Switzerland (Ethikkommission Nordwest- und Zentralschweiz - EKNZ) - Project-ID 2020-01612.

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Section: Discussionmentioning

confidence: 82%

Use of pulsatile gonadotropin-releasing hormone (GnRH) in patients with functional hypothalamic amenorrhea (FHA) results in monofollicular ovulation and high cumulative live birth rates: a 25-year cohort

Quaas

Fischer

et al. 2022

J Assist Reprod Genet

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“…The DII scores of individuals with impaired eating attitudes were high in different studies [16][17][18]. Again, in a different study, it was reported that inflammation was higher in individuals with a worse appetite according to the SNAQ results.…”

Section: Discussionmentioning

confidence: 90%

“…Eating attitude is defined as belief, thought, emotion and behaviors towards food [14] , although it is the basis of motor, cognitive, social and emotional development, but is considered a complex phenomenon regulated by environmental factors [15]. Eating attitudes also influence dietary inflammatory processes, for example, a 2021 study found that individuals with impaired eating attitudes had high DII scores [16]. Similarly, in studies on this subject, DII scores were found to be high in individuals with impaired eating attitudes [17,18].…”

Section: Introductionmentioning

confidence: 99%

The Relationship of the Inflammatory Potential of Diet With Eating Attitudes and Appetite: A Study on Nutrition and Dietetics Students

Çolak

Sarıyer

Çevik

et al. 2022

Karya Journal of Health Science

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Objective: The dietary inflammatory index (DII) is an index that examines the effects of dietary components on serum pro-inflammatory and anti-inflammatory indicators. In the studies, it was observed that the presence of inflammation caused a change in nutrient intake, and eating attitudes also influence dietary inflammatory processes. But studies that examine the relationship between dietary inflammatory potential, eating attitude, and appetite in the literature are very few and limited. The aim of this study was to examine the relationship between dietary inflammatory potential, eating attitude and appetite of the students of the Department of Nutrition and Dietetics. Method: Questions including sociodemographic characteristics and nutritional status, EAT-40 to evaluate eating attitudes, Simplified Nutritional Appetite Questionnaire (SNAQ) for assessment of appetite, and a questionnaire containing 3-day dietary recall record were applied to calculate the dietary inflammatory indices of the participants. Results: The average age of the students was 22 years and 91.9% of them were female. The frequency of the normal weight group was 69.4% and 78.3% of the students skipped meals, the most frequently skipped meal was lunch with 40.5%. Most of the students had a normal eating attitude with 92.3 percent. It was found that 95.1% of the students with normal eating attitudes were female, 49.3% were 4th-grade undergraduates and 70% were of normal weight. It was found that 91.1% of the students whose appetite status was not impaired were women and 48.9% were 4th-grade undergraduates. Most of the students with anti-inflammatory diet potential were female with 93% and, 45% were 4th-grade undergraduates while 70% of them were of normal weight. No statistically significant correlation was found between the students' EAT-40 scores and BMI, between EAT-40 and DII scores, and between BMI and DII scores (p>0.05). It was found that students' EAT-40 scores did not significantly affect DII scores (p>0.05), and BMI did not significantly affect DII scores (p>0.05). Conclusion: Dietary inflammatory potential has no effect on eating attitude and appetite.

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“…Nevertheless, altered expression levels of chemokine receptors may not be a consequence of nutrient deficiencies. Although women with AN consume less dietary zinc and cholesterol than HC, nutrient intake patterns do not contribute significantly to altered concentrations of immune markers in the blood in AN ( 90 ).…”

Section: Discussionmentioning

confidence: 99%

Expression of CXCR4 on CD4+ T cells predicts body composition parameters in female adolescents with anorexia nervosa

et al. 2022

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Anorexia nervosa (AN) is a severe eating disorder characterized by excessive weight loss and lack of recognition of the seriousness of the current low body weight. Individuals with AN frequently exhibit an enhanced inflammatory state and altered blood levels of cytokines and chemokines. However, the expression of chemokine receptors in AN and the association with body composition parameters and treatment effects are still unknown. In this study, we examined the expression of CCR4, CCR6, CXCR3, and CXCR4 on peripheral blood T cells in female adolescents with AN before (T0, n = 24) and after 6 weeks of multimodal therapy (T1, n = 20). We also investigated their value to predict body mass index (BMI) and fat mass index (FMI) at baseline. Using multi-parameter flow cytometry, we found increased expression of CCR4, CXCR3, and CXCR4, but not CCR6, on CD4+ T cells in AN at T0 when compared to healthy controls (HC, n = 20). At T1, CXCR3 and CXCR4 expression decreased in AN. We found a close link between CCR4, CCR6 and CXCR4 expression and the adolescent mental health status in the study cohort as determined by the Strengths and Difficulties Questionnaire (SDQ). Specifically, CXCR4 expression correlated positively with emotional symptoms and peer relationship problems, as well as with the total sum score of the SDQ. In addition, CXCR4 expression on CD4+ T cells was a significant predictor of BMI and FMI in female adolescents. Our findings that CXCR4 expression on T cells is altered in adolescents with AN and predicts body composition parameters in adolescents suggest an impact of this chemokine receptor in the pathogenesis of AN.

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Nutrient Intake and Dietary Inflammatory Potential in Current and Recovered Anorexia Nervosa

Cited by 7 publications

References 95 publications

Use of pulsatile gonadotropin-releasing hormone (GnRH) in patients with functional hypothalamic amenorrhea (FHA) results in monofollicular ovulation and high cumulative live birth rates: a 25-year cohort

Use of pulsatile gonadotropin-releasing hormone (GnRH) in patients with functional hypothalamic amenorrhea (FHA) results in monofollicular ovulation and high cumulative live birth rates: a 25-year cohort

The Relationship of the Inflammatory Potential of Diet With Eating Attitudes and Appetite: A Study on Nutrition and Dietetics Students

Expression of CXCR4 on CD4+ T cells predicts body composition parameters in female adolescents with anorexia nervosa

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