Nutraceuticals in food and pharmacy. A Review

A new epoch is emerging with intense research on nutraceuticals, i.e., “food or food product that provides medical or health benefits including the prevention and treatment of diseases”, such as Alzheimer’s disease. Nutraceuticals act at different biochemical and metabolic levels and much evidence shows their neuroprotective effects; in particular, they are able to provide protection against mitochondrial damage, oxidative stress, toxicity of β-amyloid and Tau and cell death. They have been shown to influence the composition of the intestinal microbiota significantly contributing to the discovery that differential microorganisms composition is associated with the formation and aggregation of cerebral toxic proteins. Further, the routes of interaction between epigenetic mechanisms and the microbiota–gut–brain axis have been elucidated, thus establishing a modulatory role of diet-induced epigenetic changes of gut microbiota in shaping the brain. This review examines recent scientific literature addressing the beneficial effects of some natural products for which mechanistic evidence to prevent or slowdown AD are available. Even if the road is still long, the results are already exceptional.

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“…Commonly, nutraceuticals can be grouped into the three main categories including Nutrients, Herbals and Food supplements [48].…”

Section: Classification Of Nutraceuticalsmentioning

confidence: 99%

Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease

Atlante

Amadoro

Bobba

et al. 2020

Cells

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“…Despite the various investigations including a known quantity of nutraceuticals in food [ 66 ], the recommended daily doses for patients with PAH have not been studied. For this reason, there is no study that analyzes the adequate amount of fruits, vegetables, cereals, and meats that a patient with PAH should consume daily.…”

Section: Nutraceutical In the Treatment Of Cardiovascular Diseasementioning

confidence: 99%

Nutraceuticals in the Treatment of Pulmonary Arterial Hypertension

Sánchez-Gloria

Osorio‐Alonso

Arellano‐Buendía

et al. 2020

IJMS

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Pulmonary arterial hypertension (PAH) is a severe disease characterized by the loss and obstructive remodeling of the pulmonary arterial wall, causing a rise in pulmonary arterial pressure and pulmonary vascular resistance, which is responsible for right heart failure, functional decline, and death. Although many drugs are available for the treatment of this condition, it continues to be life-threatening, and its long-term treatment is expensive. On the other hand, many natural compounds present in food have beneficial effects on several cardiovascular conditions. Several studies have explored many of the potential beneficial effects of natural plant products on PAH. However, the mechanisms by which natural products, such as nutraceuticals, exert protective and therapeutic effects on PAH are not fully understood. In this review, we analyze the current knowledge on nutraceuticals and their potential use in the protection and treatment of PAH, as well as whether nutraceuticals could enhance the effects of drugs used in PAH through similar mechanisms.

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“…and have a low glycemic index can minimize the escalated level of diabetic's oxidative strain and thus prevent the incidence of many chronic human maladies (Hou & Jimenez, 2020;Sawicka et al, 2019).…”

Section: Introductionmentioning

confidence: 99%