Nutraceuticals Approach as a Treatment for Cancer Cachexia

Chiocchetti, Gabriela de Matuoka e; Viana, Laís Rosa; Lopes‐Aguiar, Leisa; Miyaguti, Natália Angelo da Silva; Gomes-Marcondes, M.C.C.

doi:10.1002/9781119746843.ch14

Cited by 2 publications

(1 citation statement)

References 165 publications

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“…Additionally, some plant-based food products have shown favorable effects on physical function in healthy older adults [13]. However, the primary outcome of most nutraceutical studies in the broader cancer setting is body weight, with few studies including a measure of muscularity, patient-reported (PR-)QOL, and/or subjective physical function, as reviewed elsewhere [14][15][16]. Even fewer studies report objectively measured physical function, but as phase III cancer cachexia trials have shown, increased body weight and muscle mass are often not associated with improved PR-QOL or physical function [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

A Review of Nutraceuticals in Cancer Cachexia

Caeiro,

Gandhay,

Anderson

et al. 2023

Cancers

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Cancer cachexia is largely characterized by muscle wasting and inflammation, leading to weight loss, functional impairment, poor quality of life (QOL), and reduced survival. The main barrier to therapeutic development is a lack of efficacy for improving clinically relevant outcomes, such as physical function or QOL, yet most nutraceutical studies focus on body weight. This review describes clinical and pre-clinical nutraceutical studies outside the context of complex nutritional and/or multimodal interventions, in the setting of cancer cachexia, in view of considerations for future clinical trial design. Clinical studies mostly utilized polyunsaturated fatty acids or amino acids/derivatives, and they primarily focused on body weight and, secondarily, on muscle mass and/or QOL. The few studies that measured physical function almost exclusively utilized handgrip strength with, predominantly, no time and/or group effect. Preclinical studies focused mainly on amino acids/derivatives and polyphenols, assessing body weight, muscle mass, and occasionally physical function. While this review does not provide sufficient evidence of the efficacy of nutraceuticals for cancer cachexia, more preclinical and adequately powered clinical studies are needed, and they should focus on clinically meaningful outcomes, including physical function and QOL.

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Section: Introductionmentioning

confidence: 99%

A Review of Nutraceuticals in Cancer Cachexia

Caeiro,

Gandhay,

Anderson

et al. 2023

Cancers

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Potential Clinical Benefits And Probable Mechanisms of Action Promoted By A Nutraceutical Obtained By Fermentation And Rich In Β-Glucans And Amino Acids for Oncologic Patients

Fernandes Junior,

Tallo,

Góes

et al. 2024

jmrr

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Cancer patients are generally submitted to chemotherapy and radiotherapy, which tend to cause problems related to intense inflammatory processes, malnutrition, nausea, and emesis. Therefore, performing supplementation in these patients is important and necessary, as it favors cancer patients from a nutritional point of view. Amino acids and β-glucans obtained from fermentation processes proved to be important in the care of cancer patients because they improve the nutritional parameters and general condition of the patient. We aim to discuss the benefits obtained by cancer patients undergoing chemotherapy and radiotherapy who received supplementation with a fermented nutraceutical rich in β-glucans and amino acids. A literature review was carried out through an active search for scientific articles by the following descriptors in Portuguese: “nutraceutical”, “β-glucans”, “oncological patients”. In addition, we also discuss the benefits caused using the product called BionutriAR1®, a nutraceutical that contributes to the recovery of nutritional status. We conclude that the use of products capable of promoting supplementation of β-glucans and amino acids is beneficial to cancer patients, especially those undergoing chemotherapy and radiotherapy and, therefore, there is an indication of supplementation for these patients with the fermented product BionutriAR1®.

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Nutraceuticals Approach as a Treatment for Cancer Cachexia

Cited by 2 publications

References 165 publications

A Review of Nutraceuticals in Cancer Cachexia

A Review of Nutraceuticals in Cancer Cachexia

Potential Clinical Benefits And Probable Mechanisms of Action Promoted By A Nutraceutical Obtained By Fermentation And Rich In Β-Glucans And Amino Acids for Oncologic Patients

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