This study aims to propose a theoretical framework based on Institutional Theory in order to implement clinical-academic nursing careers (CAC), since nurses who combine care work with research tend to share best clinical practices with their colleagues, nursing students and even with their teachers.Method: The literature on CAC careers, evidence-based practice (EBP), health errors, continuing education, communities of practice and Institutional Theory was examined.Theoretical foundation: As theoretical support, we adopted literature about CAC, evidence-based practice, errors in healthcare, continuing education, communities of practice and Institutional Theory. A theoretical framework was created with five steps. Results: By introducing the CAC, the use of evidence-based practice will generate cost reduction, increased quality of services provided and greater satisfaction for these professionals.Conclusions: This study has international relevance, as it can be applied in any country that wants quality gains in the assistance provided by hospitals as well cost reduction.