The study investigated the current status of patient safety care among lowseniority nurses and analyzed the factors affecting it. Low-seniority nurses play a crucial role in ensuring patient safety and improving nursing care quality. To understand the factors influencing their ability to provide safe care, a cross-sectional survey was conducted in 10 tertiary general hospitals in Sichuan Province, China, involving 369 low-seniority nurses. Data were collected through an online self-assessment questionnaire and analyzed using various statistical methods, including descriptive analysis, Pearson correlation analysis, and multiple linear regression. The results showed that low-seniority nurses scored moderately high on patient safety care (174.67 ± 6.61). Patient safety care was positively correlated with systems thinking (r = 0.927) and attitude towards reporting adverse nursing events (r = 0.945). Multiple linear regression indicated that age, participation in patient safety training, systems thinking, and attitude towards reporting adverse nursing events significantly influenced patient safety care, explaining 91.1% of the total variance. In conclusion, patient safety care among low-seniority nurses is moderately high, and key factors affecting their ability to provide safe care include age, training, systems thinking, and attitude towards reporting adverse events. This highlights the importance of targeted interventions and support for low-seniority nurses to enhance patient safety.