Numerosity impairment in corticobasal syndrome.

Koss, Shira; Clark, Robin; Vesely, Luisa; Weinstein, Jessica; Powers, Chivon; Richmond, Lauren L.; Farag, Christine; Gross, Rachel G.; Liang, Tsao‐Wei; Grossman, Murray

doi:10.1037/a0018755

Cited by 18 publications

(30 citation statements)

References 83 publications

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“…In line with this model, past research has established the involvement of IPS with abstract quantity processing in healthy control populations (Dehaene et al, 2003; Piazza et al, 2007; Wei et al, 2014) and in patients with parietal lesions (Cipolotti et al, 1991; Takayama et al, 1994; Martory et al, 2003; Koss et al, 2010). It followed that IPS would display “supramodal interpretation of numbers”(Eger et al, 2003), and it was indeed shown that this region was activated independent of input notation of the numbers (Naccache and Dehaene, 2001; Pinel et al, 2001).…”

Section: Introductionmentioning

confidence: 80%

Neuronal Population Responses in the Human Ventral Temporal and Lateral Parietal Cortex during Arithmetic Processing with Digits and Number Words

Baek

Daitch

Pinheiro‐Chagas

et al. 2018

Journal of Cognitive Neuroscience

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Past research has identified anatomically specific regions in the posterior inferior temporal gyrus (PITG) and the intraparietal sulcus (IPS) that are engaged during arithmetic processing. In the current study, we explore whether the responses in these regions depends on the number format (i.e., numerical digits vs. number words). We collected intracranial EEG (iEEG) data from the areas surrounding the PITG in eight subjects who performed two experimental tasks containing arithmetic equations with either digits or number words. Our findings confirmed an increase in the high frequency broadband (HFB) activity in both PITG and IPS regions for equations presented in either digits or in number words compared to their respective baselines. In the PITG the HFB activations were similar for digits and number words in the time of activation but differed in magnitude. In the IPS the activity was significantly delayed for number words in comparison to digits regardless of the hemisphere. The results support the extant evidence for the engagement of the PITG during arithmetic processing regardless of input format while also revealing differences in the magnitude of power in response to the formats. The results also reveal that the IPS region becomes engaged regardless of input format but with different temporal signatures. The results add to our understanding of the temporal profile of engagement between discrete populations of neurons within the human brain during arithmetic processing with numerals versus number-words.

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Section: Introductionmentioning

confidence: 80%

Neuronal Population Responses in the Human Ventral Temporal and Lateral Parietal Cortex during Arithmetic Processing with Digits and Number Words

Baek

Daitch

Pinheiro‐Chagas

et al. 2018

Journal of Cognitive Neuroscience

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“…Majority quantifiers also rely on number knowledge as a prerequisite to the mental calculation needed to test the validity of an assertion that depends on a mental comparison or manipulation requiring working memory resources (McMillan, et al, 2005; McMillan, et al, 2006). Regardless of the distribution of quantifier subsets, we have argued that difficulty with quantifiers in CBS and bvFTD is related in part to their deficit for number knowledge and associated quantity knowledge (Koss, et al, 2010; Spotorno, et al, 2014). This is somewhat consistent with a broad interpretation of the grounded cognition approach to semantic memory (Barsalou, 2009) by which the representation of conceptual knowledge depends in part on processing associated sensory-motor features.…”

Section: Discussionmentioning

confidence: 96%

“…In CBS and bvFTD, difficulty with quantifier comprehension has also been associated with this frontal-parietal network (McMillan, et al, 2006; Morgan, et al, 2011). This same network is associated with processing quantity and number knowledge in healthy adults (Pinel, Dehaene, Riviere, & Le Bihan, 2001; Simon, et al, 2002) and in patients with neurodegenerative disease (Koss, et al, 2010; Morgan, et al, 2011; Spotorno, et al, 2014). We view this as an integrated bilateral network that is biased towards linguistic representations in the left hemisphere and magnitude vectors for quantity in the right hemisphere (Chochon, Cohen, van de Moortele, & Dehaene, 1999; Kadosh, et al, 2005).…”

Section: Discussionmentioning

confidence: 96%

“…This magnitude effect was correlated with atrophy in right superior and inferior parietal cortex. Another study (Koss, et al, 2010) assessed the representation of numerosity in non-aphasic patients with CBS by asking them to judge whether a target numerosity (e.g., “3”) falls between two bounding numerosities (e.g., “1” and “5”). Stimuli included Arabic numerals or dot arrays.…”

Section: Introductionmentioning

confidence: 99%

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Dissociation of quantifiers and object nouns in speech in focal neurodegenerative disease

et al. 2016

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Quantifiers such as many and some are thought to depend in part on the conceptual representation of number knowledge, while object nouns such as cookie and boy appear to depend in part on visual feature knowledge associated with object concepts. Further, number knowledge is associated with a frontal-parietal network while object knowledge is related in part to anterior and ventral portions of the temporal lobe. We examined the cognitive and anatomic basis for the spontaneous speech production of quantifiers and object nouns in non-aphasic patients with focal neurodegenerative disease associated with corticobasal syndrome (CBS, n=33), behavioral variant frontotemporal degeneration (bvFTD, n=54), and semantic variant primary progressive aphasia (svPPA, n=19). We recorded a semi-structured speech sample elicited from patients and healthy seniors (n=27) during description of the Cookie Theft scene. We observed a dissociation: CBS and bvFTD were significantly impaired in the production of quantifiers but not object nouns, while svPPA were significantly impaired in the production of object nouns but not quantifiers. MRI analysis revealed that quantifier production deficits in CBS and bvFTD were associated with disease in a frontal-parietal network important for number knowledge, while impaired production of object nouns in all patient groups was related to disease in inferior temporal regions important for representations of visual feature knowledge of objects. These findings imply that partially dissociable representations in semantic memory may underlie different segments of the lexicon.

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“…This phenomenon is also consistent with the adult neuropsychological literature. In adults, acalculia occurs primarily after left parietal damage (Dehaene & Cohen, 1995) but is also frequently observed in diseases characterized by bilateral hemispheric impairment, such as progressive cortical atrophy (Delazer, Karner, Zamarian, Donnemiller, & Benke, 2006) and corticobasal-ganglionic degeneration (Koss et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Impaired acuity of the approximate number system in 22q11.2 microdeletion syndrome.

Oliveira¹,

Santos²,

Vianna³

et al. 2014

Psychology & Neuroscience

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A magnitude comparison deficit has been frequently observed in velocardiofacial syndrome (Del22q11.2). We hypothesized that this deficit extends to impairments in the acuity of the approximate number system (ANS). Three groups of children aged 8-14 years were investigated: Del22q11.2 children (n = 12), low cognitive ability children (LCA; n = 12), and matched typically developing children (TD; n = 28). All children were assessed with a simple reaction time task and symbolic and nonsymbolic number comparison tasks. To estimate the acuity of the ANS, the Weber fraction (w) was calculated from the nonsymbolic comparison task. The Del22q11.2 group exhibited a significantly higher w compared with the other groups. Importantly, no significant differences were found in w between the TD and LCA groups. The performance pattern of the Del22q11.2 group was similar to the TD group in the symbolic comparison task, and both of these groups had better performance than the LCA group. The impairment of ANS acuity observed in individuals with Del22q11.2 cannot be explained by deficits in general processing speed because no significant group differences were found in the simple reaction time task. These results suggest that lower acuity of the ANS should be added to the behavioral phenotype of Del22q11.2. The absence of impaired ANS acuity in the LCA group is consistent with the hypothesis that number sense is a relatively specific and autonomous domain. Investigations of low ANS acuity in mathematics learning difficulties and Del22q11.2 should be intensified.

show abstract

Numerosity impairment in corticobasal syndrome.

Cited by 18 publications

References 83 publications

Neuronal Population Responses in the Human Ventral Temporal and Lateral Parietal Cortex during Arithmetic Processing with Digits and Number Words

Neuronal Population Responses in the Human Ventral Temporal and Lateral Parietal Cortex during Arithmetic Processing with Digits and Number Words

Dissociation of quantifiers and object nouns in speech in focal neurodegenerative disease

Impaired acuity of the approximate number system in 22q11.2 microdeletion syndrome.

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