The numerical investigations on the structural performance of reinforced concrete (RC) beam strengthened with externally bonded carbon fiber-reinforced polymer (CFRP) sheets are presented. The nonlinear characteristics of materials (i.e., stress-strain relationships of steel reinforcement, concrete, CFRP, and CFRP/concrete bond stress-slip behavior) were adopted in three-dimensional finite element (FE) models. The validation of FE models was conducted by comparing the laboratory works carried out on two RC beam specimens with 2000 mm length, 300 mm height, and 120 mm width. The numerical results show a good correlation with the experimental results of the beam specimens, such as load-displacement curves, crack patterns, and failure modes. They allow confirming the capability of the developed FE model to predict the flexural performance of strengthened beams considering CFRP/concrete interfacial behavior. Furthermore, parametric investigations were performed to determine the effect of flexural strengthening schemes, CFRP length with or without U-wraps, and multiple CFRP layers on the flexural performance of strengthened beams.