Numerical study on spatial distribution of silver nanoparticles inside whole-body type inhalation toxicity chamber

Abstract

Silver nanoparticles are among the fastest growing product categories in the nanotechnology industry. Several experimental studies reported earlier for its toxicity and its associated risks. Uniform distribution of nanoparticle concentration in inhalation toxicity exposure chambers is important in the conduct of inhalation experimental evaluation. However, relatively little is known. Several factors, including nanoparticle size, degree of mixing, and chamber design, may influence the nanoparticles distribution in whole-body exposure chamber. In the present work we investigated numerically the silver nanoparticles concentration distribution and particle trajectory in the whole body inhalation toxicity test chamber. A three dimensional numerical simulation was performed using the commercially available computational fluid dynamics code Fluent with two models, discrete phase model (DPM) and fine particle model (FPM) to calculate spatial particle trajectories and concentration. The simulated results show that the silver nanoparticle trajectories and concentration distribution are dependent on inhalation toxicity chamber geometry.

Osmotic pressure induced toxicity by aggregation of citrate-coated silver nanoparticles inside HepG2 cells

“…Silver nanoparticle (AgNP) is one of the emerging and fastest growing materials in the field of nanotechnology [1][2][3] and Biomedicine [4][5][6][7][8] that benefited from the advancements in the studies of nanoparticles [9][10][11][12][13][14] and applications such as in catalysis [15][16][17][18][19][20][21][22][23][24][25][26][27][28] . The rapid growth of Agbased nanomaterials is attributed to silver's antimicrobial properties [29][30][31][32][33][34][35] , good optical, conductive, and other outstanding properties [36][37][38][39] .…”

Theoretical studies of the interaction between silver and lipids present in HepG2 cells

“…1 The industrial application of silver has been expanding and comes in the form of silver compounds and silver nanoparticles. Silver nanoparticle industry is widely emerging [2][3] and is increasingly becoming part of our daily lives. This nanomaterial is present in cosmetics, textiles, food packaging, drug delivery systems, therapeutics, electronics, and others.…”

“…11 This type of silver material is now one of the fastest growing nanomaterial industry with wide range of applications. [2][3] It is present in topical wound dressings, cosmetics, textiles, detergent, food packaging, and many consumer products we use daily. [4][5][6][7][8] The growth in the usage of silver is often attributed to its anti-microbial properties.…”

Computational fluid dynamics applied to the ventilation of small-animal laboratory cages

“…Indeed, the use of computer modelling for assessing and optimising animal housing ventilation has been noted, 4 but to our knowledge, this technique has rarely been used in practice. 5–10 Thus, we thought that presenting the results from this analysis could be of interest.…”