A gas cyclone-liquid jet absorption separator integrates the functions of cyclone separation, liquid jet atomization, and absorption separation. This study employed this device to conduct a wet flue-gas desulfurization experiment on a gas mixture consisting of air in room temperature and sulfur dioxide (SO 2 ) to explore this device's prospect of tail gas purification. Sodium hydroxide (NaOH) and sodium carbonate (Na 2 CO 3 ) solutions at various concentrations were used as absorbents under room temperature. The changes in the SO 2 removal efficiency and air pressure drop were investigated with parameters including total gas flow, SO 2 concentration in the flue gas, and absorbent flow. The SO 2 removal efficiency increased to a certain extent as the absorbent concentration, total gas flow, and absorbent flow increased. The maximum SO 2 removal efficiencies of NaOH and Na 2 CO 3 were 85% and 77%, respectively. Under identical experimental conditions, the changes in SO 2 removal efficiencies of NaOH and Na 2 CO 3 exhibited essentially identical trends, in which NaOH exhibited a 5%-8% greater SO 2 removal efficiency than Na 2 CO 3 .