Numerical simulations on periprosthetic bone remodeling: a systematic review

Mirulla, Agostino Igor; Pinelli, S; Zaffagnini, Stefano; Nigrelli, Vincenzo; Ingrassia, Tommaso; Paolo, Stefano Di; Bragonzoni, Laura

doi:10.1016/j.cmpb.2021.106072

Cited by 12 publications

(4 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…What about the bone-implant system mechanical integrity? While this strain-based theory has also been widely investigated in the context of peri-implant tissue remodeling (Huiskes et al, 1987;Mirulla et al, 2021), its relevance is not obvious.…”

Section: What Is the Marker Of Bone Mechanical Integrity?mentioning

confidence: 99%

Osteocyte pericellular and perilacunar matrices as markers of bone–implant mechanical integrity

Gauthier¹,

Follet²,

Trunfio-Sfarghiu³

et al. 2022

Biocell

View full text Add to dashboard Cite

To develop durable bone healing strategies through improved control of bone repair, it is of critical importance to understand the mechanisms of bone mechanical integrity when in contact with biomaterials and implants. Bone mechanical integrity is defined here as the adaptation of structural properties of remodeled bone in regard to an applied mechanical loading. Accordingly, the authors present why future investigations in bone repair and regeneration should emphasize on the matrix surrounding the osteocytes. Osteocytes are mechanosensitive cells considered as the orchestrators of bone remodeling, which is the biological process involved in bone homeostasis. These bone cells are trapped in an interconnected porous network, the lacunocanalicular network, which is embedded in a bone mineralized extracellular matrix. As a consequence of an applied mechanical loading, the bone deformation results in the deformation of this lacunocanalicular network inducing a shift in interstitial fluid pressure and velocity, thus resulting in osteocyte stimulation.The material environment surrounding each osteocyte, the so called perilacunar and pericellular matrices properties, define its mechanosensitivity. While this mechanical stimulation pathway is well known, the laws used to predict bone remodeling are based on strains developing at a tissue scale, suggesting that these strains are related to the shift in fluid pressure and velocity at the lacunocanalicular scale. While this relationship has been validated through observation in healthy bone, the fluid behavior at the bone-implant interface is more complex. The presence of the implant modifies fluid behavior, so that for the same strain at a tissue scale, the shift in fluid pressure and velocity will be different than in a healthy bone tissue. In that context, new markers for bone mechanical integrity, considering fluid behavior, have to be defined. The viewpoint exposed by the authors indicates that the properties of the pericellular and the perilacunar matrices have to be systematically investigated and used as structural markers of fluid behavior in the course of bone biomaterial development.

show abstract

Section: What Is the Marker Of Bone Mechanical Integrity?mentioning

confidence: 99%

Osteocyte pericellular and perilacunar matrices as markers of bone–implant mechanical integrity

Gauthier¹,

Follet²,

Trunfio-Sfarghiu³

et al. 2022

Biocell

View full text Add to dashboard Cite

show abstract

“…As a result, the bone receives inadequate stress stimulation. According to Wolff’s law, the high-stress stimulation promotes the structural strengthening of the bone, whereas peri-implant bone resorption and even fracture could be produced by low-stress stimulation (Mirulla et al 2021 ; Zhang et al 2020 ). Hence, reducing stress shielding is necessary for the application of metal blocks.…”

Section: Introductionmentioning

confidence: 99%

Porous metal block based on topology optimization to treat distal femoral bone defect in total knee revision

Zhang

Han

et al. 2023

Biomech Model Mechanobiol

View full text Add to dashboard Cite

Metal block augmentations are common solutions in treating bone defects of total knee revision. However, the stress shielding and poor osteointegration resulted from metal block application could not be neglected in bone defects restoration. In this study, a novel porous metal block was designed with topology optimization to improve biomechanical performance. The biomechanical difference of the topologically optimized block, solid Ti6Al4V block, and porous Ti6Al4V block in treating bone defects of total knee revision was compared by finite element analysis. The inhomogeneous femoral model was created according to the computed tomography data. Combined with porous structures, minimum compliance topology optimization subjected to the volume fraction constraint was utilized for the redesign of the metal block. The region of interest was defined as a 10 mm area of the distal femur beneath the contacting surface. The biomechanical performance of daily motions was investigated. The von Mises stress, the strain energy density of the region of interest, and the von Mises stress of metal blocks were recorded. The results were analyzed in SPSS. In terms of the region of interest, the maximum von Mises stress of the topological optimized group increased obviously, and its average stress was significantly higher than that of the other groups (p < 0.05). Moreover, the topologically optimized block group had the highest maximum strain energy density of the three groups, and the lowest maximum stress of block was also found in this group. In this study, the stress shielding reduction and stress transfer capability were found obviously improved through topology optimization. Therefore, the topological optimized porous block is recommended in treating bone defects of total knee revision. Meanwhile, this study also provided a novel approach for mechanical optimization in block designing.

show abstract

“…Using three-dimensional finite element analysis (FEA), a previous study found evidence that subchondral bone may have little protective effect on the deep cancellous bone, which plays a major role in the degenerative collapse of the femoral head [ 7 ]. During bone reconstruction, both the proximal cortical and cancellous bones of the human femur have been found to form an optimal shape structure, with a balanced distribution of stress [ 8 ]. Living bone changes its composition, structure, and external morphology depending on the stress experienced.…”

Section: Introductionmentioning

confidence: 99%

Comparison of femoral mechanics before and after internal fixation removal and the effect of sclerosis on femoral stress: a finite element analysis

Liu

Song

Liang

et al. 2022

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background Femoral neck fractures are a common traumatic injury. The removal of the internal fixation remains controversial, especially in terms of mechanical stability. Moreover, collapsed necrosis of the femoral head continues to occur after fracture healing. We believe that sclerotic cancellous bone (SCB) formation around the screw is associated with femoral head necrosis. We aimed to compare mechanical features before and after implant removal and determine the effect of SCB formation on stress distribution. Methods Cylindrical cancellous bone sections were collected from a relatively normal region and an SCB region of a necrotic femoral head, and their elastic moduli were measured. Four femoral finite element models were developed: a) femoral neck fracture healing with implants, b) fracture healing without implants, c) sclerosis around the screw with implants, and d) sclerosis around the screw without implants. Results The maximum von Mises peak stresses of models a and b were 66.643 MPa and 63.76 MPa, respectively, and were concentrated in the upper lateral femur. The main stress was scattered at the lowest screw tail, femoral calcar region, and lateral femur shaft. Moreover, coronal plane strain throughout the screw paths near the femoral head in models a and b was mostly in the range of 1000–3000 με. The maximum stress concentrations in models c and d were located at the lower femoral head and reached 91.199 MPa and 78.019 MPa, respectively. Conclusions The stresses in the sclerotic model around the cannulated screws are more concentrated on the femoral head than in the healing model without sclerotic bone. The overall stresses in the healing femoral neck fracture model were essentially unchanged before and after removal of the internal fixation.

show abstract

Numerical simulations on periprosthetic bone remodeling: a systematic review

Cited by 12 publications

References 83 publications

Osteocyte pericellular and perilacunar matrices as markers of bone–implant mechanical integrity

Osteocyte pericellular and perilacunar matrices as markers of bone–implant mechanical integrity

Porous metal block based on topology optimization to treat distal femoral bone defect in total knee revision

Comparison of femoral mechanics before and after internal fixation removal and the effect of sclerosis on femoral stress: a finite element analysis

Contact Info

Product

Resources

About