Numerical simulation on development of a SAW based biosensor

Ten, Seng Teik; Hashim, U.; Sudin, Ahmad; Arshad, M. K. Md; Liu, Weiwen; Foo, K. L.; Voon, C. H.; Wee, F. H.; Lee, Yeng Seng; Salleh, N.H.M.; Nazwa, T.

doi:10.1063/1.4948907

AIP Conference Proceedings

2016

DOI: 10.1063/1.4948907

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Numerical simulation on development of a SAW based biosensor

Seng Teik Ten

U. Hashim

Ahmad Sudin

et al.

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Cited by 2 publications

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“…Surface acoustic waves are normally used in telecommunication such as a filter and transceiver [13] and also used as sensing [14]. At this moment, the SAW device is used towards a new application to study the effect of SAW on cell analysis [15].…”

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confidence: 99%

A Numerical Study of Collective Cell Migration in a Microchannel Driven by Surface Acoustic Wave (SAW) Device

Mazalan

Noor

Wahab

et al. 2023

J. Phys.: Conf. Ser.

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Collective cell migration is involved in a variety of biological contexts, including tissue morphogenesis, wound healing, and cancer invasion. Many studies have revealed that chemical, mechanical, and electrical stimulation all affect cell migration. Although an acoustic stimulus has been shown to influence cell migration in the past, the underlying mechanism is still unknown. A computational model that accounts for acoustic–structure interaction was constructed in this study to simulate the formation of a surface acoustic wave (SAW) field and the application of the acoustic pressure field on collective cell migration. A group of cells within a microchannel device and two ports of interdigitated transducers (IDTs) with different wavelengths were modeled. The stresses within cells were investigated as it was influenced by substrate displacement and pressure acoustic in the cell media generated by the SAW device. As a result, we observed the local stress within cells near the solid-fluid interfaces. For propagating SAW, the shorter wavelength of IDTs (600 μm) attributed to high stress at the cell’s top and bottom as compared to the SAW device with the longer wavelength (1000 μm). The standing SAW occurred underneath collective cells. The results of standing SAW on cell stress at the bottom confirm that the SAW device can be useful to regulate the abnormalities cellular activities associated with cell migration.

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confidence: 99%

A Numerical Study of Collective Cell Migration in a Microchannel Driven by Surface Acoustic Wave (SAW) Device

Mazalan

Noor

Wahab

et al. 2023

J. Phys.: Conf. Ser.

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Finite element simulation of a highly sensitive SH-SAW delay line sensor with SiO $$_{2}$$ 2 micro-ridges

Trivedi

Nemade

2018

Microsyst Technol

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Numerical simulation on development of a SAW based biosensor

Cited by 2 publications

References 13 publications

A Numerical Study of Collective Cell Migration in a Microchannel Driven by Surface Acoustic Wave (SAW) Device

A Numerical Study of Collective Cell Migration in a Microchannel Driven by Surface Acoustic Wave (SAW) Device

Finite element simulation of a highly sensitive SH-SAW delay line sensor with SiO $$_{2}$$ 2 micro-ridges

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