Transport and deposition behavior of mineral particles driven by hydrothermal plumes along mid-ocean ridges is one of the least understood processes in geoscience. We reveal the mechanism and three typical transport patterns of particles emitted from submarine vents and subsequently laden by plumes in the stratified deep ocean with or without crossflows, that is, suspension, near-vent deposition, and long-distance transport, by developing a Lagrangian model coupled with a computational fluid dynamics model and using in situ measurements as model inputs. The particle trajectories suggest a general expression that predicts a linear variation of deposition location with the reciprocal of settling velocity, which potentially leads to a power law distribution of sediment mass along the radial direction. Our findings provide a new perspective on the accumulation of sediments near hydrothermal vents, indicating a critical role of the entrainment of plumes and consequent vortex systems in controlling deposition flux. Plain Language Summary Motion for mineral particles driven by hydrothermal plumes in the deep ocean is not well understood due to the complex environment involving a nonuniform background and ocean currents. To characterize particle trajectories and corresponding sediment distribution, we trace mineral particles using specialized computer code and analyze the results of the model. We find that the fate of particles mainly depends on the terminal velocity that they attain in the settling process, that is, the settling velocity which is related to particle size and density. Only the particles of the settling velocity within a specific range can deposit near the vent, while the larger/denser ones may stay suspended upon the vent and the smaller/lighter ones will always follow the plume mainstream. Due to the horizontal inward flows at the edge of plumes, called entrainment flows, and the resulting vortexes, settling particles would be concentrated at the near-vent region. This hydrodynamic mechanism for controlling deposition flux provides a new perspective on the enrichment of seafloor sediment and can improve understanding of the evolution of animals living in the deep ocean. This knowledge gap is mainly due to the complex nature of ocean environments, that is, stratification and crossflows, which renders tracing hydrothermal particles a significant challenge. Stratification greatly complicates the problem since it is prone to suppress the vertical motion of fluids (Ardekani & ©2020. American Geophysical Union. All Rights Reserved.