Powder Technology

2020

DOI: 10.1016/j.powtec.2020.02.009

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Numerical simulation of magnetic nanoparticle-based drug delivery in presence of atherosclerotic plaques and under the effects of magnetic field

Mostafa Varmazyar

¹

,

MohammadReza Habibi²,

et al.

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Introduction2

Magnetic Nanoparticles (Mnps) In Hyperthermia1

Applications Of Microscale1

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Cited by 23 publications

(4 citation statements)

References 46 publications

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“…MNPs can easily permeate through the blood–brain barrier, which is desirable for glioblastoma treatment [ 51 , 52 ]. MNPs are also deliverable with drug molecules [ 53 ]. This feature could make MNPs dual-model nanoparticles for serving better therapeutic assays.…”

Section: Magnetic Nanoparticles (Mnps) In Hyperthermiamentioning

confidence: 99%

Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

¹

,

²

2021

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Hydrogels are spatially organized hydrophilic polymeric systems that exhibit unique features in hydrated conditions. Among the hydrogel family, composite hydrogels are a special class that are defined as filler-containing systems with some tailor-made properties. The composite hydrogel family includes magnetic-nanoparticle-integrated hydrogels. Magnetic hydrogels (MHGs) show magneto-responsiveness, which is observed when they are placed in a magnetic field (static or oscillating). Because of their tunable porosity and internal morphology they can be used in several biomedical applications, especially diffusion-related smart devices. External stimuli may influence physical and chemical changes in these hydrogels, particularly in terms of volume and shape morphing. One of the most significant external stimuli for hydrogels is a magnetic field. This review embraces a brief overview of the fabrication of MHGs and two of their usages in the biomedical area: drug delivery and hyperthermia-based anti-cancer activity. As for the saturation magnetization imposed on composite MHGs, they are easily heated in the presence of an alternating magnetic field and the temperature increment is dependent on the magnetic nanoparticle concentration and exposure time. Herein, we also discuss the mode of different therapies based on non-contact hyperthermia heating.

“…MNPs can easily permeate through the blood–brain barrier, which is desirable for glioblastoma treatment [ 51 , 52 ]. MNPs are also deliverable with drug molecules [ 53 ]. This feature could make MNPs dual-model nanoparticles for serving better therapeutic assays.…”

Section: Magnetic Nanoparticles (Mnps) In Hyperthermiamentioning

confidence: 99%

Design of Magnetic Hydrogels for Hyperthermia and Drug Delivery

¹

,

²

2021

View full text Add to dashboard Cite

Hydrogels are spatially organized hydrophilic polymeric systems that exhibit unique features in hydrated conditions. Among the hydrogel family, composite hydrogels are a special class that are defined as filler-containing systems with some tailor-made properties. The composite hydrogel family includes magnetic-nanoparticle-integrated hydrogels. Magnetic hydrogels (MHGs) show magneto-responsiveness, which is observed when they are placed in a magnetic field (static or oscillating). Because of their tunable porosity and internal morphology they can be used in several biomedical applications, especially diffusion-related smart devices. External stimuli may influence physical and chemical changes in these hydrogels, particularly in terms of volume and shape morphing. One of the most significant external stimuli for hydrogels is a magnetic field. This review embraces a brief overview of the fabrication of MHGs and two of their usages in the biomedical area: drug delivery and hyperthermia-based anti-cancer activity. As for the saturation magnetization imposed on composite MHGs, they are easily heated in the presence of an alternating magnetic field and the temperature increment is dependent on the magnetic nanoparticle concentration and exposure time. Herein, we also discuss the mode of different therapies based on non-contact hyperthermia heating.

“…As a result, secondary effects such as response and property change occur. Mixing is also a technique utilized in most microfluidic devices for medical diagnostics, chemical manufacturing, drug discovery, and other applications [ 234 , 235 , 236 ]. The three traditional mixing methods are macromixing, mesomixing, and micromixing.…”

Section: Applications Of Microscalementioning

confidence: 99%

A Review of the Methods of Modeling Multi-Phase Flows within Different Microchannels Shapes and Their Applications

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²

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³

et al. 2021

Micromachines

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In industrial processes, the microtechnology concept refers to the operation of small devices that integrate the elements of operational and reaction units to save energy and space. The advancement of knowledge in the field of microfluidics has resulted in fabricating devices with different applications in micro and nanoscales. Micro- and nano-devices can provide energy-efficient systems due to their high thermal performance. Fluid flow in microchannels and microstructures has been widely considered by researchers in the last two decades. In this paper, a review study on fluid flow within microstructures is performed. The present study aims to present the results obtained in previous studies on this type of system. First, different types of flows in microchannels are examined. The present article will then review previous articles and present a general summary in each section. Then, the multi-phase flows inside the microchannels are discussed, and the flows inside the micropumps, microturbines, and micromixers are evaluated. According to the literature review, it is found that the use of microstructures enhances energy efficiency. The results of previous investigations revealed that the use of nanofluids as a working fluid in microstructures improves energy efficiency. Previous studies have demonstrated special attention to the design aspects of microchannels and micro-devices compared to other design strategies to improve their performance. Finally, general concluding remarks are presented, and the existing challenges in the use of these devices and suggestions for future investigations are presented.

“…They also investigated how the wire’s location as a magnetic source affected the MDT. In their numerical simulation of magnetic nanoparticle-based medication delivery, Varmazyar et al [ 14 ] used two cases: one with a slight obstruction and the other with two mild and severe blockages. Ramadan et al [ 15 ] analyzed the blood flow incorporating gold nanoparticles via a stenosed tapering artery using the Phan-Thien-Tanner fluid model to treat the terrible cancer disease.…”

Section: Introductionmentioning

confidence: 99%

Computer Simulations of EMHD Casson Nanofluid Flow of Blood through an Irregular Stenotic Permeable Artery: Application of Koo-Kleinstreuer-Li Correlations

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²

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³

et al. 2023

Nanomaterials

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A novel analysis of the electromagnetohydrodynamic (EMHD) non-Newtonian nanofluid blood flow incorporating CuO and Al2O3 nanoparticles through a permeable walled diseased artery having irregular stenosis and an aneurysm is analyzed in this paper. The non-Newtonian behavior of blood flow is addressed by the Casson fluid model. The effective viscosity and thermal conductivity of nanofluids are calculated using the Koo-Kleinstreuer-Li model, which takes into account the Brownian motion of nanoparticles. The mild stenosis approximation is employed to reduce the bi-directional flow of blood to uni-directional. The blood flow is influenced by an electric field along with a magnetic field perpendicular to the blood flow. The governing mathematical equations are solved using Crank-Nicolson finite difference approach. The model has been developed and validated by comparing the current results to previously published benchmarks that are peculiar to this study. The results are utilized to investigate the impact of physical factors on momentum diffusion and heat transfer. The Nusselt number escalates with increasing CuO nanoparticle diameter and diminishing the diameter of Al2O3 nanoparticles. The relative % variation in Nusselt number enhances with Magnetic number, whereas a declining trend is obtained for the electric field parameter. The present study’s findings may be helpful in the diagnosis of hemodynamic abnormalities and the fields of nano-hemodynamics, nano-pharmacology, drug delivery, tissue regeneration, wound healing, and blood purification systems.

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