Crossing borehole is an effective means to eliminate the outburst risk of coal and gas. The influence of borehole inclination angle, borehole diameter, and drainage time on the effective radius of gas drainage are studied by numerical simulation and engineering example verification. The study shows that the effective radius changes in a “U” shape with the increase in borehole inclination angle. When the angle α of the borehole and coal seam plane decreases, the effective radius increases. Furthermore, the coal mass around the borehole is broken by shear deformation, which is consistent with the results of the inner peephole. The effective radiuses are different in coal seam dip X and strike Y. When α is small, the effective radius in the X direction is generally wider. When α is large (α ≤ 90°), the effective radiuses in the X and Y directions are close. The effective radius is positively correlated with the borehole diameter and is more significantly influenced by increasing borehole diameter when α is small. The effective radius increases as a negative exponential function with time and eventually converges to a constant. The study has practical implications for the design of crossing borehole in the coal seam floor.