Numerical simulation of blood flow effects on rupture of aneurysm in middle cerebral artery

The rupture of the aneurysm wall is highly associated with the hemodynamic feature of bloodstream as well as the geometrical feature of the aneurysm. Coiling is known as the most conventional technique for the treatment of intracranial cerebral aneurysms (ICA) in which blood stream is obstructed from entering the sac of the aneurysm. In this study, comprehensive efforts are done to disclose the impacts of the coiling technique on the aneurysm progress and risk of rupture. The computational fluid dynamic method is used for the analysis of the blood hemodynamics in the specific ICA. The impacts of the pulsatile blood stream on the high-risk region are also explained. Wall shear Stress (WSS) and Oscillatory shear index (OSI) factors are also compared in different blood viscosities and coiling conditions. According to our study, the hematocrit test (Hct) effect is evident (25% reduction in maximum WSS) in the two first stages (maximum acceleration and peak systolic). Our findings present that reduction of porosity from 0.89 to 0.79 would decrease maximum WSS by about 8% in both HCT conditions.

Section: Introductionmentioning

confidence: 99%

Computational study of the blood hemodynamic inside the cerebral double dome aneurysm filling with endovascular coiling

Rostamian

Fallah

Rostamiyan

et al. 2023

“…the accumulation of red blood cells, in addition to the adhesion and aggregation of both leukocytes and platelets along the intimal surface occurs when blood flow locally stagnated. Indeed, high WSS results in mechanical stimulation and consequently, dysfunction of flow-induced nitric oxide occurs in this condition [21][22][23] . According to previous studies, to maintain the feature of the aneurysmal wall, WSS of 2 Pa is appropriate in which deterioration of endothelial cells is noticed in the lower WSS.…”

mentioning

confidence: 99%

Computational study of blood flow inside MCA aneurysm with/without endovascular coiling

Sadeh

Kazemi

Bahramkhoo

et al. 2023

The simulation of blood hemodynamics inside the MCA aneurysm is done to investigate the potential region for rupture and hemorrhage. The main focus of this work is to disclose the impacts of endovascular coiling on blood hemodynamics and the risk of aneurysm rupture. Navier–stokes equations are solved for the computational study of blood flow while it is assumed that flow remains laminar, unsteady, and non-Newtonian. Influences of blood hematocrits and coiling porosity are also examined in this work. Obtained results show that impacts of blood hematocrit on the maximum OSI are limited in the MCA case.

“…It should be considered that the blood stream inside the arteries follows the rhythm of heart pulse and this has high influence on the growth and rupture of the aneurysms. Although several works have been developed for the hemodynamic study of the blood stream inside the aneurysms [15][16][17] , the most previous works just select superficial aneurysm model for case studies. Meanwhile, correct characteristics of blood stream is not also considered for their evaluations.…”

mentioning

confidence: 99%

Influence of the coiling porosity on the risk reduction of the cerebral aneurysm rupture: computational study

Sheidani

Gerdroodbary

Poozesh

et al. 2022

The formation and progress of cerebral aneurysm is highly associated with hemodynamic factors and blood flow feature. In this study, comprehensive efforts are done to investigate the blood hemodynamic effects on the creation and growth of the Internal Carotid Artery. The computational fluid dynamic method is used for the visualization of the bloodstream inside the aneurysm. Transitional, non-Newtonian and incompressible conditions are considered for solving the Navier–Stokes equation to achieve the high-risk region on the aneurysm wall. OSI and WSS of the aneurysm wall are compared within different blood flow stages. The effects of blood viscosity and coiling treatment on these factors are presented in this work. Our study shows that in male patients (HCT = 0.45), changing the porosity of coiling from 0.89 with 0.79 would decreases maximum OSI up to 75% (in maximum acceleration). However, this effect is limited to about 45% for female patients (HCT = 0.35).