Numerical simulation of aneurysmal haemodynamics with calibrated porous-medium models of flow-diverting stents

Li, Yujie; Zhang, Mingzi; Verrelli, David I.; Chong, Winston; Ohta, Makoto; Qian, Yi

doi:10.1016/j.jbiomech.2018.08.026

Cited by 32 publications

(15 citation statements)

References 19 publications

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“…Lieber and coworkers extensively studied the aneurysmal flow circulation in the presence of a FDS, illustrating that the capability of diminishing the inflow is a function of the stent shape and strut diameter [9,10]. Studies on the stent effects on aneurysm circulation have also been carried out by using computational fluid dynamics (CFD) [1,7,8,[11][12][13][14]. For example, the effects of stent mesh shape were investigated by Aenis et al [11], Rhee et al [15] Bando and Berger [16], Stuhne and Steinman [17] and Cebral and Lohner [18].…”

Section: Introductionmentioning

confidence: 99%

CFD-Based Comparison Study of a New Flow Diverting Stent and Commercially-Available Ones for the Treatment of Cerebral Aneurysms

et al. 2019

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Flow-diverting stents (FDSs) show considerable promise for the treatment of cerebral aneurysms by diverting blood flow away from the aneurysmal sacs, however, post-treatment complications such as failure of occlusion and subarachnoid haemorrhaging remain and vary with the FDS used. Based on computational fluid dynamics (CFD), this study aimed to investigate the performance of a new biodegradable stent as compared to two metallic commercially available FDSs. CFD models were developed for an idealized cerebral artery with a sidewall aneurysmal sac treated by deploying the aforementioned stents of different porosities (90, 80, and 70 % ) respectively. By using these models, the simulation and analysis were performed, with a focus on comparing the local hemodynamics or the blood flow in the stented arteries as compared to the one without the stent deployment. For the comparison, we computed and compared the flow velocity, wall shear stress (WSS) and pressure distributions, as well as the WSS related indices, all of which are of important parameters for studying the occlusion and potential rupture of the aneurysm. Our results illustrate that the WSS decreases within the aneurysmal sac on the treated arteries, which is more significant for the stents with lower porosity or finer mesh. Our results also show that the maximum WSS near the aneurysmal neck increases regardless of the stents used. In addition, the WSS related indices including the time-average WSS, oscillatory shear index and relative residence time show different distributions, depending on the FDSs. Together, we found that the finer mesh stents provide more flow reduction and smaller region characterized by high oscillatory shear index, while the new stent has a higher relative residence time.

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Section: Introductionmentioning

confidence: 99%

CFD-Based Comparison Study of a New Flow Diverting Stent and Commercially-Available Ones for the Treatment of Cerebral Aneurysms

et al. 2019

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“…Where the specific values of permeability K and loss coefficient C were 0.001489 mm 2 and 7,665 m −1 , which was obtained according to FD stent properties (Li Y. et al, 2018). All models were established using Solidworks (France) commercial software.…”

Section: Flow Field Calculation Of Cerebral Aneurysm Model Before and After Fd Stent Placementmentioning

confidence: 99%

“…Currently, strokes, including cerebral aneurysms, have the highest mortality rate of diseases worldwide (Tsai et al, 2018). Flow-diverting (FD) stent placement is a common and effective method for treating cerebral aneurysms (Li Y. et al, 2018). A large number of studies have shown that analyzing hemodynamics (such as flow velocity field, pressure field, etc.)…”

Section: Introductionmentioning

confidence: 99%

Prediction of Cerebral Aneurysm Hemodynamics With Porous-Medium Models of Flow-Diverting Stents via Deep Learning

Song

Wang

et al. 2021

Front. Physiol.

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The interventional treatment of cerebral aneurysm requires hemodynamics to provide proper guidance. Computational fluid dynamics (CFD) is gradually used in calculating cerebral aneurysm hemodynamics before and after flow-diverting (FD) stent placement. However, the complex operation (such as the construction and placement simulation of fully resolved or porous-medium FD stent) and high computational cost of CFD hinder its application. To solve these problems, we applied aneurysm hemodynamics point cloud data sets and a deep learning network with double input and sampling channels. The flexible point cloud format can represent the geometry and flow distribution of different aneurysms before and after FD stent (represented by porous medium layer) placement with high resolution. The proposed network can directly analyze the relationship between aneurysm geometry and internal hemodynamics, to further realize the flow field prediction and avoid the complex operation of CFD. Statistical analysis shows that the prediction results of hemodynamics by our deep learning method are consistent with the CFD method (error function <13%), but the calculation time is significantly reduced 1,800 times. This study develops a novel deep learning method that can accurately predict the hemodynamics of different cerebral aneurysms before and after FD stent placement with low computational cost and simple operation processes.

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“…Figure 6 shows the results of the variation in shear stress with a stent implanted in the artery. There has also been research into the development of equipment, such as the analysis developed by Dehlahi and colleagues (2008) [33], which compares the properties of different stent models.…”

Section: The Use Of Cfd In Atherosclerosismentioning

confidence: 99%

Computational Fluid Dynamics Applied to Atherosclerosis Hemodynamics: A Brief Review

Sodré¹,

Santos²,

Tofaneli³

et al. 2019

JBTH

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In recent years, Computational Fluid Dynamics (CFD) has been applied to biological systems for the study of physiological properties and the development of new medical devices. It has also been used for the hemodynamic evaluation of care in the diagnosis, treatment, and prevention of cardiovascular diseases. This article presents a brief analysis of the application of Computational Fluid Dynamics in hemodynamics in atherosclerosis, with a review of CFD in the study of blood flow, and in the medical area.

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Numerical simulation of aneurysmal haemodynamics with calibrated porous-medium models of flow-diverting stents

Cited by 32 publications

References 19 publications

CFD-Based Comparison Study of a New Flow Diverting Stent and Commercially-Available Ones for the Treatment of Cerebral Aneurysms

CFD-Based Comparison Study of a New Flow Diverting Stent and Commercially-Available Ones for the Treatment of Cerebral Aneurysms

Prediction of Cerebral Aneurysm Hemodynamics With Porous-Medium Models of Flow-Diverting Stents via Deep Learning

Computational Fluid Dynamics Applied to Atherosclerosis Hemodynamics: A Brief Review

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