In steel production processes, there are various diffusion-related phenomena, and these are controlled to obtain the required steel quality. In the refining process, the slag-metal reaction that is controlled by the diffusion of various reactants and products in boundary layers in both the slag and metal side along the slag-metal interface is analyzed by a coupled reaction model. Solidification microsegregation is controlled by the solute diffusion in the liquid and solid phases, and various analytical microsegregation models have been proposed. The tertiary precipitation of nonmetallic inclusions is also affected by solute diffusion in the solid phase and is analyzed by a coupled precipitation model, the modified solidification segregation model. The formation of a carbon (C)-rich band structure along the centerline of steel plates and weld cracking are also prevented by regulating the diffusion of C by accelerated cooling and by encouraging hydrogen to diffuse out by preheating the weld part, respectively. A key element of intragranular ferrite precipitation for ferrite grain refinement is the formation of manganese (Mn)-depleted zone by slow Mn diffusion around a precipitate.